메뉴 건너뛰기




Volumn 93, Issue 6, 2013, Pages 625-634

Cyclic di-GMP mediates Mycobacterium tuberculosis dormancy and pathogenecity

Author keywords

Cyclic di GMP; Dormancy; Mycobacterium tuberculosis; Pathogenicity; Signaling

Indexed keywords

CYCLIC GMP; TRANSCRIPTOME;

EID: 84887402489     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2013.09.002     Document Type: Article
Times cited : (25)

References (49)
  • 1
    • 0036467798 scopus 로고    scopus 로고
    • Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection
    • 10.1086/338342
    • T. Lillebaek, A. Dirksen, I. Baess, B. Strunge, V.O. Thomsen, and A.B. Andersen Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection J Infect Dis 185 2002 401 404 10.1086/338342
    • (2002) J Infect Dis , vol.185 , pp. 401-404
    • Lillebaek, T.1    Dirksen, A.2    Baess, I.3    Strunge, B.4    Thomsen, V.O.5    Andersen, A.B.6
  • 2
    • 43049182981 scopus 로고    scopus 로고
    • The enduring hypoxic response of Mycobacterium tuberculosis
    • 10.1371/journal.pone.0001502
    • T.R. Rustad, M.I. Harrell, R. Liao, and D.R. Sherman The enduring hypoxic response of Mycobacterium tuberculosis PLoS ONE 3 2008 e1502 10.1371/journal.pone.0001502
    • (2008) PLoS ONE , vol.3 , pp. 1502
    • Rustad, T.R.1    Harrell, M.I.2    Liao, R.3    Sherman, D.R.4
  • 3
    • 0029976980 scopus 로고    scopus 로고
    • An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
    • L.G. Wayne, and L.G. Hayes An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence Infect Immun 64 1996 2062 2069
    • (1996) Infect Immun , vol.64 , pp. 2062-2069
    • Wayne, L.G.1    Hayes, L.G.2
  • 4
    • 59749096131 scopus 로고    scopus 로고
    • In vitro model of mycobacterial growth arrest using nitric oxide with limited air
    • 10.1128/AAC.00442-08
    • S. Hussain, M. Malik, L. Shi, M.L. Gennaro, and K. Drlica In vitro model of mycobacterial growth arrest using nitric oxide with limited air Antimicrobial Agents Chemother 53 2009 157 161 10.1128/AAC.00442-08
    • (2009) Antimicrobial Agents Chemother , vol.53 , pp. 157-161
    • Hussain, S.1    Malik, M.2    Shi, L.3    Gennaro, M.L.4    Drlica, K.5
  • 6
    • 77956277547 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C
    • 10.1371/journal.pone.0010860
    • N.K. Taneja, S. Dhingra, A. Mittal, M. Naresh, and J.S. Tyagi Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C PLoS ONE 5 2010 e10860 10.1371/journal.pone.0010860
    • (2010) PLoS ONE , vol.5 , pp. 10860
    • Taneja, N.K.1    Dhingra, S.2    Mittal, A.3    Naresh, M.4    Tyagi, J.S.5
  • 7
    • 77949356979 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy
    • 10.1128/JB.00926-09
    • R.L. Leistikow, R.A. Morton, I.L. Bartek, I. Frimpong, K. Wagner, and M.I. Voskuil The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy J Bacteriol 192 2010 1662 1670 10.1128/JB.00926-09
    • (2010) J Bacteriol , vol.192 , pp. 1662-1670
    • Leistikow, R.L.1    Morton, R.A.2    Bartek, I.L.3    Frimpong, I.4    Wagner, K.5    Voskuil, M.I.6
  • 8
    • 0036951936 scopus 로고    scopus 로고
    • Mycobacterium bovis BCG response regulator essential for hypoxic dormancy
    • C. Boon, and T. Dick Mycobacterium bovis BCG response regulator essential for hypoxic dormancy J Bacteriol 184 2002 6760 6767
    • (2002) J Bacteriol , vol.184 , pp. 6760-6767
    • Boon, C.1    Dick, T.2
  • 9
    • 0035912791 scopus 로고    scopus 로고
    • Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin
    • 10.1073/pnas.121172498
    • D.R. Sherman, M. Voskuil, D. Schnappinger, R. Liao, M.I. Harrell, and G.K. Schoolnik Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin Proc Natl Acad Sci U S A 98 2001 7534 7539 10.1073/pnas.121172498
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7534-7539
    • Sherman, D.R.1    Voskuil, M.2    Schnappinger, D.3    Liao, R.4    Harrell, M.I.5    Schoolnik, G.K.6
  • 11
    • 49649095474 scopus 로고    scopus 로고
    • Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon
    • 10.1074/jbc.M802274200
    • A. Kumar, J.S. Deshane, D.K. Crossman, S. Bolisetty, B.S. Yan, I. Kramnik, A. Agarwal, and A.J. Steyn Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon J Biol Chem 283 2008 18032 18039 10.1074/jbc.M802274200
    • (2008) J Biol Chem , vol.283 , pp. 18032-18039
    • Kumar, A.1    Deshane, J.S.2    Crossman, D.K.3    Bolisetty, S.4    Yan, B.S.5    Kramnik, I.6    Agarwal, A.7    Steyn, A.J.8
  • 14
    • 4544243679 scopus 로고    scopus 로고
    • Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice
    • 10.1084/jem.20040646
    • P.C. Karakousis, T. Yoshimatsu, G. Lamichhane, S.C. Woolwine, E.L. Nuermberger, J. Grosset, and W.R. Bishai Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice J Exp Med 200 2004 647 657 10.1084/jem.20040646
    • (2004) J Exp Med , vol.200 , pp. 647-657
    • Karakousis, P.C.1    Yoshimatsu, T.2    Lamichhane, G.3    Woolwine, S.C.4    Nuermberger, E.L.5    Grosset, J.6    Bishai, W.R.7
  • 15
    • 33750934574 scopus 로고    scopus 로고
    • Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection
    • 10.1111/j.1574-695X.2006.00160.x
    • D. Sharma, A. Bose, H. Shakila, T.K. Das, J.S. Tyagi, and V.D. Ramanathan Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection FEMS Immunol Med Microbiol 48 2006 329 336 10.1111/j.1574-695X.2006.00160.x
    • (2006) FEMS Immunol Med Microbiol , vol.48 , pp. 329-336
    • Sharma, D.1    Bose, A.2    Shakila, H.3    Das, T.K.4    Tyagi, J.S.5    Ramanathan, V.D.6
  • 16
    • 34547568747 scopus 로고    scopus 로고
    • DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis
    • 10.1110/ps.072897707
    • E.H. Sousa, J.R. Tuckerman, G. Gonzalez, and M.A. Gilles-Gonzalez DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis Protein Sci 16 2007 1708 1719 10.1110/ps.072897707
    • (2007) Protein Sci , vol.16 , pp. 1708-1719
    • Sousa, E.H.1    Tuckerman, J.R.2    Gonzalez, G.3    Gilles-Gonzalez, M.A.4
  • 17
    • 27144485413 scopus 로고    scopus 로고
    • A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem
    • 10.1016/j.jmb.2005.09.011
    • S. Sardiwal, S.L. Kendall, F. Movahedzadeh, S.C. Rison, N.G. Stoker, and S. Djordjevic A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem J Mol Biol 353 2005 929 936 10.1016/j.jmb.2005.09.011
    • (2005) J Mol Biol , vol.353 , pp. 929-936
    • Sardiwal, S.1    Kendall, S.L.2    Movahedzadeh, F.3    Rison, S.C.4    Stoker, N.G.5    Djordjevic, S.6
  • 18
    • 34147117736 scopus 로고    scopus 로고
    • DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis
    • 10.1021/bi602422p
    • A. Ioanoviciu, E.T. Yukl, P. Moenne-Loccoz, and P.R. de Montellano DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis Biochemistry 46 2007 4250 4260 10.1021/bi602422p
    • (2007) Biochemistry , vol.46 , pp. 4250-4260
    • Ioanoviciu, A.1    Yukl, E.T.2    Moenne-Loccoz, P.3    De Montellano, P.R.4
  • 19
    • 34547458490 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
    • 10.1073/pnas.0705054104
    • A. Kumar, J.C. Toledo, R.P. Patel, J.R. Lancaster Jr., and A.J. Steyn Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor Proc Natl Acad Sci U S A 104 2007 11568 11573 10.1073/pnas.0705054104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 11568-11573
    • Kumar, A.1    Toledo, J.C.2    Patel, R.P.3    Lancaster, Jr.J.R.4    Steyn, A.J.5
  • 20
    • 34548228384 scopus 로고    scopus 로고
    • Interdomain interactions within the two-component heme-based sensor DevS from Mycobacterium tuberculosis
    • 10.1021/bi7008695
    • E.T. Yukl, A. Ioanoviciu, P.R. de Montellano, and P. Moenne-Loccoz Interdomain interactions within the two-component heme-based sensor DevS from Mycobacterium tuberculosis Biochemistry 46 2007 9728 9736 10.1021/bi7008695
    • (2007) Biochemistry , vol.46 , pp. 9728-9736
    • Yukl, E.T.1    Ioanoviciu, A.2    De Montellano, P.R.3    Moenne-Loccoz, P.4
  • 21
    • 44949128202 scopus 로고    scopus 로고
    • Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: Implication in the induction of DevR target genes
    • 10.1128/JB.01308-07
    • S. Chauhan, and J.S. Tyagi Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes J Bacteriol 190 2008 4301 4312 10.1128/JB.01308-07
    • (2008) J Bacteriol , vol.190 , pp. 4301-4312
    • Chauhan, S.1    Tyagi, J.S.2
  • 24
    • 67650132403 scopus 로고    scopus 로고
    • Hypoxia: A window into Mycobacterium tuberculosis latency
    • 10.1111/j.1462-5822.2009.01325.x
    • T.R. Rustad, A.M. Sherrid, K.J. Minch, and D.R. Sherman Hypoxia: a window into Mycobacterium tuberculosis latency Cell Microbiol 11 2009 1151 1159 10.1111/j.1462-5822.2009.01325.x
    • (2009) Cell Microbiol , vol.11 , pp. 1151-1159
    • Rustad, T.R.1    Sherrid, A.M.2    Minch, K.J.3    Sherman, D.R.4
  • 25
    • 70349274104 scopus 로고    scopus 로고
    • Structural and mechanistic determinants of c-di-GMP signalling
    • 10.1038/nrmicro2203 nrmicro2203 [pii]
    • T. Schirmer, and U. Jenal Structural and mechanistic determinants of c-di-GMP signalling Nat Rev Microbiol 7 2009 724 735 10.1038/nrmicro2203 nrmicro2203 [pii]
    • (2009) Nat Rev Microbiol , vol.7 , pp. 724-735
    • Schirmer, T.1    Jenal, U.2
  • 26
    • 63049137897 scopus 로고    scopus 로고
    • Principles of c-di-GMP signalling in bacteria
    • R. Hengge Principles of c-di-GMP signalling in bacteria Nature Rev Microbiol 7 2009 263 273
    • (2009) Nature Rev Microbiol , vol.7 , pp. 263-273
    • Hengge, R.1
  • 27
    • 78649800745 scopus 로고    scopus 로고
    • Identification, activity and disulfide connectivity of c-di-GMP regulating proteins in Mycobacterium tuberculosis
    • 10.1371/journal.pone.0015072
    • K. Gupta, P. Kumar, and D. Chatterji Identification, activity and disulfide connectivity of c-di-GMP regulating proteins in Mycobacterium tuberculosis PLoS ONE 5 2010 e15072 10.1371/journal.pone.0015072
    • (2010) PLoS ONE , vol.5 , pp. 15072
    • Gupta, K.1    Kumar, P.2    Chatterji, D.3
  • 28
    • 84861918212 scopus 로고    scopus 로고
    • A full length bifunctional protein involved in c-di-GMP turnover is required for long term survival under nutrient starvation in Mycobacterium smegmatis
    • 10.1099/mic.0.053892-0
    • B.K. Bharati, I.M. Sharma, S. Kasetty, M. Kumar, R. Mukherjee, and D. Chatterji A full length bifunctional protein involved in c-di-GMP turnover is required for long term survival under nutrient starvation in Mycobacterium smegmatis Microbiology 158 2012 1415 1427 10.1099/mic.0.053892-0
    • (2012) Microbiology , vol.158 , pp. 1415-1427
    • Bharati, B.K.1    Sharma, I.M.2    Kasetty, S.3    Kumar, M.4    Mukherjee, R.5    Chatterji, D.6
  • 29
    • 0033880508 scopus 로고    scopus 로고
    • Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement
    • T. Parish, and N.G. Stoker Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement Microbiology 146 Pt 8 2000 1969 1975
    • (2000) Microbiology , vol.146 , Issue.PART 8 , pp. 1969-1975
    • Parish, T.1    Stoker, N.G.2
  • 30
    • 0033988815 scopus 로고    scopus 로고
    • Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages
    • J. Wei, J.L. Dahl, J.W. Moulder, E.A. Roberts, P. O'Gaora, D.B. Young, and R.L. Friedman Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages J Bacteriol 182 2000 377 384
    • (2000) J Bacteriol , vol.182 , pp. 377-384
    • Wei, J.1    Dahl, J.L.2    Moulder, J.W.3    Roberts, E.A.4    O'Gaora, P.5    Young, D.B.6    Friedman, R.L.7
  • 31
    • 0030734277 scopus 로고    scopus 로고
    • C-di-GMP-binding protein, a new factor regulating cellulose synthesis in Acetobacter xylinum
    • H. Weinhouse, S. Sapir, D. Amikam, Y. Shilo, G. Volman, P. Ohana, and M. Benziman c-di-GMP-binding protein, a new factor regulating cellulose synthesis in Acetobacter xylinum FEBS Lett 416 1997 207 211
    • (1997) FEBS Lett , vol.416 , pp. 207-211
    • Weinhouse, H.1    Sapir, S.2    Amikam, D.3    Shilo, Y.4    Volman, G.5    Ohana, P.6    Benziman, M.7
  • 32
    • 84878938296 scopus 로고    scopus 로고
    • The LuxR family regulator Rv0195 modulates Mycobacterium tuberculosis dormancy and virulence
    • 10.1016/j.tube.2013.04.005
    • H. Fang, D. Yu, Y. Hong, X. Zhou, C. Li, and B. Sun The LuxR family regulator Rv0195 modulates Mycobacterium tuberculosis dormancy and virulence Tuberculosis (Edinb) 93 2013 425 431 10.1016/j.tube.2013.04.005
    • (2013) Tuberculosis (Edinb) , vol.93 , pp. 425-431
    • Fang, H.1    Yu, D.2    Hong, Y.3    Zhou, X.4    Li, C.5    Sun, B.6
  • 33
    • 65649115454 scopus 로고    scopus 로고
    • Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth
    • 10.1099/mic.0.024638-0
    • S. Wu, P.F. Barnes, B. Samten, X. Pang, S. Rodrigue, S. Ghanny, P. Soteropoulos, L. Gaudreau, and S.T. Howard Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth Microbiology 155 2009 1272 1281 10.1099/mic.0.024638-0
    • (2009) Microbiology , vol.155 , pp. 1272-1281
    • Wu, S.1    Barnes, P.F.2    Samten, B.3    Pang, X.4    Rodrigue, S.5    Ghanny, S.6    Soteropoulos, P.7    Gaudreau, L.8    Howard, S.T.9
  • 34
    • 27544469136 scopus 로고    scopus 로고
    • Macrophage uptake and recycling of ascorbic acid: Response to activation by lipopolysaccharide
    • 10.1016/j.freeradbiomed.2005.07.006
    • J.M. May, J. Huang, and Z.C. Qu Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide Free Radic Biol Med 39 2005 1449 1459 10.1016/j.freeradbiomed.2005.07.006
    • (2005) Free Radic Biol Med , vol.39 , pp. 1449-1459
    • May, J.M.1    Huang, J.2    Qu, Z.C.3
  • 35
    • 0008929713 scopus 로고    scopus 로고
    • Preferential uptake and accumulation of oxidized vitamin C by THP-1 monocytic cells
    • H. Laggner, V. Besau, and H. Goldenberg Preferential uptake and accumulation of oxidized vitamin C by THP-1 monocytic cells Eur J Biochem 262 1999 659 665
    • (1999) Eur J Biochem , vol.262 , pp. 659-665
    • Laggner, H.1    Besau, V.2    Goldenberg, H.3
  • 36
    • 0029015720 scopus 로고
    • Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms
    • R.W. Welch, Y. Wang, A. Crossman Jr., J.B. Park, K.L. Kirk, and M. Levine Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms J Biol Chem 270 1995 12584 12592
    • (1995) J Biol Chem , vol.270 , pp. 12584-12592
    • Welch, R.W.1    Wang, Y.2    Crossman, Jr.A.3    Park, J.B.4    Kirk, K.L.5    Levine, M.6
  • 37
    • 0034780485 scopus 로고    scopus 로고
    • Nonreplicating persistence of Mycobacterium tuberculosis
    • 10.1146/annurev.micro.55.1.139
    • L.G. Wayne, and C.D. Sohaskey Nonreplicating persistence of Mycobacterium tuberculosis Annu Rev Microbiol 55 2001 139 163 10.1146/annurev.micro.55.1.139
    • (2001) Annu Rev Microbiol , vol.55 , pp. 139-163
    • Wayne, L.G.1    Sohaskey, C.D.2
  • 38
    • 0033043776 scopus 로고    scopus 로고
    • Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages
    • M.S. Gomes, S. Paul, A.L. Moreira, R. Appelberg, M. Rabinovitch, and G. Kaplan Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages Infect Immun 67 1999 3199 3206
    • (1999) Infect Immun , vol.67 , pp. 3199-3206
    • Gomes, M.S.1    Paul, S.2    Moreira, A.L.3    Appelberg, R.4    Rabinovitch, M.5    Kaplan, G.6
  • 39
    • 38749151604 scopus 로고    scopus 로고
    • Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network
    • 10.1128/JB.01273-07
    • J.H. Lee, P.C. Karakousis, and W.R. Bishai Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network J Bacteriol 190 2008 699 707 10.1128/JB.01273-07
    • (2008) J Bacteriol , vol.190 , pp. 699-707
    • Lee, J.H.1    Karakousis, P.C.2    Bishai, W.R.3
  • 40
    • 35848951876 scopus 로고    scopus 로고
    • Roles of cyclic diguanylate in the regulation of bacterial pathogenesis
    • 10.1146/annurev.micro.61.080706.093426
    • R. Tamayo, J.T. Pratt, and A. Camilli Roles of cyclic diguanylate in the regulation of bacterial pathogenesis Annu Rev Microbiol 61 2007 131 148 10.1146/annurev.micro.61.080706.093426
    • (2007) Annu Rev Microbiol , vol.61 , pp. 131-148
    • Tamayo, R.1    Pratt, J.T.2    Camilli, A.3
  • 41
    • 23944431512 scopus 로고    scopus 로고
    • Cyclic diguanylate regulates Vibrio cholerae virulence gene expression
    • 10.1128/IAI.73.9.5873-5882.2005
    • A.D. Tischler, and A. Camilli Cyclic diguanylate regulates Vibrio cholerae virulence gene expression Infect Immun 73 2005 5873 5882 10.1128/IAI.73.9.5873-5882.2005
    • (2005) Infect Immun , vol.73 , pp. 5873-5882
    • Tischler, A.D.1    Camilli, A.2
  • 42
    • 19944422767 scopus 로고    scopus 로고
    • A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: Role of cyclic diGMP
    • 10.1111/j.1365-2958.2005.04632.x
    • K.B. Hisert, M. MacCoss, M.U. Shiloh, K.H. Darwin, S. Singh, R.A. Jones, S. Ehrt, Z. Zhang, B.L. Gaffney, S. Gandotra, D.W. Holden, D. Murray, and C. Nathan A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP Mol Microbiol 56 2005 1234 1245 10.1111/j.1365-2958.2005.04632. x
    • (2005) Mol Microbiol , vol.56 , pp. 1234-1245
    • Hisert, K.B.1    Maccoss, M.2    Shiloh, M.U.3    Darwin, K.H.4    Singh, S.5    Jones, R.A.6    Ehrt, S.7    Zhang, Z.8    Gaffney, B.L.9    Gandotra, S.10    Holden, D.W.11    Murray, D.12    Nathan, C.13
  • 45
    • 33750503812 scopus 로고    scopus 로고
    • Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice
    • 10.1002/path.2055
    • S. Aly, K. Wagner, C. Keller, S. Malm, A. Malzan, S. Brandau, F.C. Bange, and S. Ehlers Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice J Pathol 210 2006 298 305 10.1002/path.2055
    • (2006) J Pathol , vol.210 , pp. 298-305
    • Aly, S.1    Wagner, K.2    Keller, C.3    Malm, S.4    Malzan, A.5    Brandau, S.6    Bange, F.C.7    Ehlers, S.8
  • 46
    • 84860431572 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis growth following aerobic expression of the DosR regulon
    • 10.1371/journal.pone.0035935
    • K. Minch, T. Rustad, and D.R. Sherman Mycobacterium tuberculosis growth following aerobic expression of the DosR regulon PLoS ONE 7 2012 e35935 10.1371/journal.pone.0035935
    • (2012) PLoS ONE , vol.7 , pp. 35935
    • Minch, K.1    Rustad, T.2    Sherman, D.R.3
  • 47
    • 79959856937 scopus 로고    scopus 로고
    • Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks
    • 10.1371/journal.ppat.1002133
    • M. He, Z. Ouyang, B. Troxell, H. Xu, A. Moh, J. Piesman, M.V. Norgard, M. Gomelsky, and X.F. Yang Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks PLoS Pathog 7 2011 e1002133 10.1371/journal.ppat. 1002133
    • (2011) PLoS Pathog , vol.7 , pp. 1002133
    • He, M.1    Ouyang, Z.2    Troxell, B.3    Xu, H.4    Moh, A.5    Piesman, J.6    Norgard, M.V.7    Gomelsky, M.8    Yang, X.F.9
  • 48
    • 48649084066 scopus 로고    scopus 로고
    • C-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection
    • 10.1016/j.vaccine.2008.06.099
    • A.D. Ogunniyi, J.C. Paton, A.C. Kirby, J.A. McCullers, J. Cook, M. Hyodo, Y. Hayakawa, and D.K. Karaolis c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection Vaccine 26 2008 4676 4685 10.1016/j.vaccine.2008.06.099
    • (2008) Vaccine , vol.26 , pp. 4676-4685
    • Ogunniyi, A.D.1    Paton, J.C.2    Kirby, A.C.3    McCullers, J.A.4    Cook, J.5    Hyodo, M.6    Hayakawa, Y.7    Karaolis, D.K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.