Stimulation of mTORC1 with L-leucine Rescues Defects Associated with Roberts Syndrome

PLoS Genetics

Volumn 9, Issue 10, 2013, Pages

  Xu, Baoshan ^a   Lee, Kenneth K ^a   Zhang, Lily ^a   Gerton, Jennifer L ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; CASPASE 3; CASPASE 7; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN P53; PROTEIN S6; RIBOSOME RNA; S6 KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL CYCLE G2 PHASE; CELL FUNCTION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DNA FRAGMENTATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ESCO2 GENE; GENE; GENE FREQUENCY; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RIBOSOME; ROBERTS SYNDROME; SIGNAL TRANSDUCTION; START CODON;

ACETYLTRANSFERASES; ANIMALS; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; CRANIOFACIAL ABNORMALITIES; ECTROMELIA; EMBRYONIC DEVELOPMENT; HUMANS; HYPERTELORISM; LEUCINE; MULTIPROTEIN COMPLEXES; RNA, RIBOSOMAL; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH;

EID: 84887292335     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003857     Document Type: Article

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