Brain iron deposition in white matter hyperintensities: A 3-T MRI study

Age

Volumn 35, Issue 5, 2013, Pages 1927-1936

  Yan, Shenqiang ^a   Sun, Jianzhong ^a   Chen, Yi ^a   Selim, Magdy ^b   Lou, Min ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Ageing; Iron; Leukoaraiosis; Susceptibility weighted imaging; Transverse relaxation rate; Whitematter hyperintensities

Indexed keywords

BIOLOGICAL MARKER; IRON;

ADULT; AGED; AGING; AMNESIA; ARTICLE; CAUDATE NUCLEUS; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DIZZINESS; FEMALE; FRONTAL CORTEX; GAIT DISORDER; GLOBUS PALLIDUS; HUMAN; INCIDENTAL FINDING; IRON STORAGE; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PUTAMEN; RED NUCLEUS; RISK FACTOR; SUBSTANTIA NIGRA; SUSCEPTIBILITY WEIGHTED IMAGING; THALAMUS; WHITE MATTER; WHITE MATTER HYPERINTENSITY;

ADULT; AGED; AGED, 80 AND OVER; AGING; BRAIN; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IRON; LEUKOARAIOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS;

EID: 84887255824     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9487-6     Document Type: Article

References (41)

1. Adams CW (1988) Perivascular iron deposition and other vascular damage in multiple sclerosis. J Neurol Neurosurg Psychiatry 51(2):260-265
2. Aquino D, Bizzi A, Grisoli M, Garavaglia B, Bruzzone MG, Nardocci N, Savoiardo M, Chiapparini L (2009) Agerelated iron deposition in the basal ganglia: quantitative analysis in healthy subjects. Radiology 252(1):165-172
3. Baba K, Shibata R, Sibuya M (2004) Partial correlation and conditional correlation as measures of conditional independence. Aust New Z J Stat 46(4):657-664. doi:10.1111/ j.1467-842X.2004.00360.x
4. Bizzi A, Brooks RA, Brunetti A, Hill JM, Alger JR, Miletich RS, Francavilla TL, Di Chiro G (1990) Role of iron and ferritin in MR imaging of the brain: a study in primates at different field strengths. Radiology 177(1):59-65
5. Black S, Gao F, Bilbao J (2009) Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment. Stroke 40(3 Suppl):S48-S52
6. Chen JC, Hardy PA, Kucharczyk W, Clauberg M, Joshi JG, Vourlas A, Dhar M, Henkelman RM (1993) MR of human postmortem brain tissue: correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease. AJNR Am J Neuroradiol 14(2):275-281
7. Connor JR, Snyder BS, Arosio P, Loeffler DA, LeWitt P (1995) A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains. J Neurochem 65(2):717-724
8. de Leeuw FE, de Groot JC, Achten E, Oudkerk M, Ramos LM, Heijboer R, Hofman A, Jolles J, van Gijn J, Breteler MM (2001) Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 70(1):9-14
9. de Rochefort L, Liu T, Kressler B, Liu J, Spincemaille P, Lebon V, Wu J, Wang Y (2010) Quantitative susceptibility map reconstruction from MR phase data using bayesian regularization: validation and application to brain imaging. Magn Reson Med 63(1):194-206
10. Debette S, Markus HS (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 341:c3666
11. DeCarli C, Maisog J, Murphy DG, Teichberg D, Rapoport SI, Horwitz B (1992) Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J Comput Assist Tomogr 16(2):274-284
12. DeCarli C, Murphy DG, Tranh M, Grady CL, Haxby JV, Gillette JA, Salerno JA, Gonzales-Aviles A, Horwitz B, Rapoport SI et al (1995) The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology 45 (11):2077-2084
13. Dwork AJ, Schon EA, Herbert J (1988) Nonidentical distribution of transferrin and ferric iron in human brain. Neuroscience 27(1):333-345
14. Erkinjuntti T, Benavente O, Eliasziw M, Munoz DG, Sulkava R, Haltia M, Hachinski V (1996) Diffuse vacuolization (spongiosis) and arteriolosclerosis in the frontal white matter occurs in vascular dementia. Arch Neurol 53 (4):325-332
15. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 (3):189-198
16. Fornage M, Chiang YA, O'Meara ES, Psaty BM, Reiner AP, Siscovick DS, Tracy RP, Longstreth WT Jr (2008) Biomarkers of inflammation and MRI-defined small vessel disease of the brain: the Cardiovascular Health Study. Stroke 39(7):1952-1959
17. Francois C, Nguyen-Legros J, Percheron G (1981) Topographical and cytological localization of iron in rat and monkey brains. Brain Res 215(1-2):317-322
18. Gebril OH, Simpson JE, Kirby J, Brayne C, Ince PG (2011) Brain iron dysregulation and the risk of ageing white matter lesions. Neuromol Med 13(4):289-299
19. Gelman N, Gorell JM, Barker PB, Savage RM, Spickler EM, Windham JP, Knight RA (1999) MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. Radiology 210 (3):759-767
20. Haacke EM, Xu Y, Cheng YC, Reichenbach JR (2004) Susceptibility weighted imaging (SWI). Magn Reson Med 52 (3):612-618
21. Haacke EM, Ayaz M, Khan A, Manova ES, Krishnamurthy B, Gollapalli L, Ciulla C, Kim I, Petersen F, Kirsch W (2007) Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 26(2):256-264
22. Haacke EM, Mittal S, Wu Z, Neelavalli J, Cheng YC (2009) Susceptibility-weighted imaging: technical aspects and clinical applications, part 1. AJNR Am J Neuroradiol 30 (1):19-30
23. Hallgren B, Sourander P (1958) The effect of age on the nonhaemin iron in the human brain. J Neurochem 3(1):41-51
24. Izawa T, Yamate J, Franklin RJ, Kuwamura M (2010) Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat. Brain Res 1349:105-114
25. Langkammer C, Krebs N, Goessler W, Scheurer E, Ebner F, Yen K, Fazekas F, Ropele S (2010) Quantitative MR imaging of brain iron: a postmortem validation study. Radiology 257 (2):455-462
26. Langkammer C, Schweser F, Krebs N, Deistung A, Goessler W, Scheurer E, Sommer K, Reishofer G, Yen K, Fazekas F, Ropele S, Reichenbach JR (2012) Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study. NeuroImage 62(3):1593-1599
27. Lee J, Koh D, Ong CN (1989) Statistical evaluation of agreement between two methods for measuring a quantitative variable. Comput Biol Med 19(1):61-70
28. LeVine SM, Chakrabarty A (2004) The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann N Y Acad Sci 1012:252-266
29. LeVine SM, Macklin WB (1990) Iron-enriched oligodendrocytes: a reexamination of their spatial distribution. J Neurosci Res 26(4):508-512
30. Lou M, Al-Hazzani A, Goddeau RP, Novak V, Selim M (2009) Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage. Stroke 41(1):34-40
31. Matsusue E, Sugihara S, Fujii S, Ohama E, Kinoshita T, Ogawa T (2006) White matter changes in elderly people: MR-pathologic correlations. Magn Reson Med Sci 5(2):99-104
32. Ogg RJ, Langston JW, Haacke EM, Steen RG, Taylor JS (1999) The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 17(8):1141-1148
33. Pfefferbaum A, Adalsteinsson E, Rohlfing T, Sullivan EV (2009) MRI estimates of brain iron concentration in normal aging: comparison of field-dependent (FDRI) and phase (SWI) methods. NeuroImage 47(2):493-500
34. Pu Y, Liu Y, Hou J, Fox PT, Gao JH (2000) Demonstration of the medullary lamellae of the human red nucleus with highresolution gradient-echo MR imaging. AJNR Am J Neuroradiol 21(7):1243-1247
35. Selim M, Yeatts S, Goldstein JN, Gomes J, Greenberg S, Morgenstern LB, Schlaug G, Torbey M, Waldman B, Xi G, Palesch Y (2011) Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage. Stroke 42(11):3067-3074
36. Singh AV, Zamboni P (2009) Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab 29(12):1867-1878
37. Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, Niessen WJ, Breteler MM, van der Lugt A (2007) Incidental findings on brain MRI in the general population. N Engl J Med 357(18):1821-1828
38. Wen W, Sachdev P (2004) The topography of white matter hyperintensities on brain MRI in healthy 60- to 64-yearold individuals. NeuroImage 22(1):144-154
39. Xu H, Stamova B, Jickling G, Tian Y, Zhan X, Ander BP, Liu D, Turner R, Rosand J, Goldstein LB, Furie KL, Verro P, Johnston SC, Sharp FR, Decarli CS (2010) Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. Stroke 41(12):2744-2749
40. Yan SQ, Sun JZ, Yan YQ, Wang H, Lou M (2012) Evaluation of brain iron content based on magnetic resonance imaging (MRI): comparison among phase value, R2 and magnitude signal intensity. PLoS One 7(2):e31748
41. Yao B, Li TQ, Gelderen P, Shmueli K, de Zwart JA, Duyn JH (2009) Susceptibility contrast in high field MRI of human brain as a function of tissue iron content. NeuroImage 44 (4):1259-1266