Prospective observational comparison of clinical outcomes between African-American and caucasian patients receiving second-line treatment with pemetrexed for advanced non-small-cell lung cancer

Clinical Lung Cancer

Volumn 14, Issue 6, 2013, Pages 726-735

  Pennella, Eduardo ^a   Obasaju, Coleman K ^a   Pohl, Gerhardt ^a   Peltz, Gerson ^a   Girvan, Allicia C ^a   Winfree, Katherine B ^a   Martinez, Betzaida ^a   Marciniak, Martin ^a   Walker, Mark S ^b   Stepanski, Edward ^b   Schwartzberg, Lee S ^c   Adjei, Alex ^d  

^a Lilly USA   (United States)

^b ACORN Research LLC   (United States)

^c West Clinic   (United States)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Ethnicity; Nonsquamous NSCLC; Observational study; Pemetrexed; Symptoms

Indexed keywords

PEMETREXED;

ADULT; ADVANCED CANCER; AFRICAN AMERICAN; AGED; ALOPECIA; ARTICLE; CANCER CONTROL; CANCER PATIENT; CANCER STAGING; CAUCASIAN; DIARRHEA; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; KAPLAN MEIER METHOD; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OBSERVATIONAL STUDY; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; RACE DIFFERENCE; SYMPTOM; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ETHNICITY; NONSQUAMOUS NSCLC; OBSERVATIONAL STUDY; PEMETREXED; SYMPTOMS;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUTAMATES; GUANINE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84887229364     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.1016/j.cllc.2013.06.011     Document Type: Article

References (32)

1. Ries L, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review: 1975-2005. Available at: http://seer.cancer.gov/csr/1975-2005/results-merged/ topic-historical-mort-trends.pdf. Accessed October 24, 2012.
2. S.M. Gadgeel, R.K. Severson, and Y. Kau Impact of race in lung cancer: analysis of temporal trends from a surveillance, epidemiology, and end results database Chest 120 2001 55 63
3. Cancer Facts & Figures for African Americans 2007-2008 2008 American Cancer Society Atlanta, GA
4. C.S. Lathan, B.A. Neville, and C.C. Earle The effect of race on invasive staging and surgery in non-small-cell lung cancer J Clin Oncol 24 2006 413 418
5. A.W. Blackstock, J.E. Herndon 2nd, and E.D. Paskett Outcomes among African-American/non-African-American patients with advanced non-small-cell lung carcinoma: report from the Cancer and Leukemia Group B J Natl Cancer Inst 94 2002 284 290
6. T.L. Evans, W. Wang, and J. Schiller Survival outcome of African American versus non-African American patients with advanced non-small cell lung cancer in first-line treatment studies by the Eastern Cooperative Oncology Group (ECOG) J Clin Oncol 2 2005 16 (suppl) (abstract 7154)
7. C. Ikpeazu, M. Vangel, and J.H. Schiller Survival in advanced non-small cell lung cancer (NSCLC) with platinum-based chemotherapy in two Eastern Cooperative Group trials: the influence of race Proc Am Soc Clin Oncol 22 2003 (abstract 2593)
8. C.R. Mulligan, A.D. Meram, and C.D. Proctor Unlimited access to care: effect on racial disparity and prognostic factors in lung cancer Cancer Epidemiol Biomarkers Prev 15 2006 25 31
9. A.S. Bryant, and R.J. Cerfolio Impact of race on outcomes of patients with non-small cell lung cancer J Thorac Oncol 3 2008 711 715
10. A. Kallab, A.P. Jillela, and P.M. Dainer Influence of race and gender on non-small cell lung cancer (NSCLC) survival Proc Am Soc Clin Oncol 20 2001 (abstract 2756)
11. L.E. Raez, T. Koru-Sengul, and G. Allen Racial/ethnic disparities in lung cancer stage of diagnosis and survival J Clin Oncol 27 2009 15 (suppl) (abstract 8080)
12. L.B. Hughes, T.M. Beasley, and H. Patel Racial or ethnic differences in allele frequencies of methylenetetrahydrofolate reductase gene and their single-nucleotide polymorphisms in the influence on response to methotrexate in rheumatoid arthritis Ann Rheum Dis 65 2006 1213 1218
13. M.V. Mandola, J. Stoehlmacher, and S. Muller-Weeks A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity Cancer Res 63 2003 2898 2904
14. S.J. Wang, C.D. Fuller, and C.R. Thomas Jr. Ethnic disparities in conditional survival of patients with non-small cell lung cancer J Thorac Oncol 2 2007 180 190
15. L.S. Freedman, R. Simon, and M.A. Foulkes Inclusion of women and minorities in clinical trials and the NIH Revitalization Act of 1993-the perspective of NIH clinical trialists Control Clin Trials 16 1995 277 285 discussion 286-9, 293-309
16. W. Du, S.M. Gadgeel, and M.S. Simon Predictors of enrollment in lung cancer clinical trials Cancer 106 2006 420 425
17. V.H. Murthy, H.M. Krumholz, and C.P. Gross Participation in cancer clinical trials: race-, sex-, and age-based disparities JAMA 291 2004 2720 2726
18. N. Hanna, F.A. Shepherd, and F.V. Fossella Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy J Clin Oncol 22 2004 1589 1597
19. G. Scagliotti, N. Hanna, and F. Fossella The differential efficacy of pemetrexed according to NSCLC histology: a review of two Phase III studies Oncologist 14 2009 253 263
20. G.V. Scagliotti, P. Parikh, and J. von Pawel Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer J Clin Oncol 26 2008 3543 3551
21. T. Ciuleanu, T. Brodowicz, and C. Zielinski Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study Lancet 374 2009 1432 1440
22. C.K. Obasaju, R.H. Ansari, and M.A. Socinski A comparison of white and African American outcomes from a three-arm, randomized, phase III multicenter trial of advanced or metastatic non-small cell lung cancer J Thorac Oncol 5 2010 993 1000
23. F.L. Greene, D.L. Page, and I.D. Fleming American Joint Committee on Cancer. AJCC Cancer Staging Manual. 6th edition 2002 Springer New York, NY
24. G.G. Fillenbaum Screening the elderly. A brief instrumental activities of daily living measures J Am Geriatr Soc 33 1986 698 706
25. C.S. Cleeland, T.R. Mendoza, and X.S. Wang Assessing symptom distress in cancer patients Cancer 89 2000 1634 1646
26. G. Piaggio, D.R. Elbourne, and D.G. Altman Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement [published erratum appears in: JAMA 2006; 296:1842] JAMA 295 2006 1152 1160
27. M.P. Lawton The functional assessment of elderly people J Am Geriatr Soc 19 1971 465 481
28. D. Gandara, Y. Ohe, and K. Kubota Japan-SWOG common arm analysis of paclitaxel/carboplatin in advanced stage non-small cell lung cancer (NSCLC): a model for prospective comparison of cooperative group trials J Clin Oncol 22 2004 14S (abstract 7007)
29. J. Crowley, K. Furuse, and M. Kawahara Second Japan-SWOG common arm analysis of paclitaxel/carboplatin in advanced stage non-small cell lung cancer (NSCLC): a model for testing population-related pharmacogenomics J Clin Oncol 24 2006 18S (abstract 7050)
30. D. Gandara, T. Kawaguchi, and J. Crowley Pharmacogenomic (PG) analysis of Japan-SWOG common arm study in advanced stage non-small cell lung cancer (NSCLC): a model for testing population-related pharmacogenomics J Clin Oncol 25 2007 18S (abstract 7500)
31. Ford J, Howerton M, Bolen S. Knowledge and access to information on recruitment of underrepresented populations to cancer clinical trials. Rockville, MD: AHRQ; 2005.
32. OSI-774 in African American patients with advanced and previously treated non-small cell lung cancer. NCT00230126 2008-updated 18 December 2012. Available at: http://clinicaltrials.gov/ct2/results?term=NCT00230126. Accessed June 10, 2013.