The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis

Clinical and Experimental Nephrology

Volumn 17, Issue 5, 2013, Pages 634-637

  Arimura, Yoshihiro ^a   Kawashima, Soko ^a   Yoshihara, Ken ^a   Komagata, Yoshinori ^a   Kaname, Shinya ^a   Yamada, Akira ^a  

^a KYORIN UNIVERSITY   (Japan)

Author keywords

Extracellular MPO; In situ immune complex; MPO ANCA associated glomerulonephritis; MPO positive cells

Indexed keywords

ANTIBODY; CD34 ANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C3; CYTOKINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; INTERLEUKIN 6; MYELOPEROXIDASE; MYELOPEROXIDASE ANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIBODY TITER; ANTIGEN ANTIBODY COMPLEX; CELLULAR DISTRIBUTION; CELLULAR SECRETION; CHROMATIN; COMPLEMENT DEPOSITION; DISEASE SEVERITY; ENZYME BINDING; ENZYME BLOOD LEVEL; ENZYME RELEASE; GLOMERULONEPHRITIS; GLOMERULUS CAPILLARY; GLOMERULUS CAPILLARY NECROSIS; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; MPO ANCA ASSOCIATED GLOMERULONEPHRITIS; MPO ANCA ASSOCIATED VASCULITIS; NECROSIS; NEUTROPHIL; PATHOPHYSIOLOGY; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RELAPSE; REMISSION; REVIEW;

ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; CAPILLARIES; CYTOKINES; GLOMERULONEPHRITIS; HUMANS; KIDNEY GLOMERULUS; NEUTROPHILS; PEROXIDASE; PROGNOSIS; RECURRENCE; REMISSION INDUCTION;

EID: 84887223408     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-013-0787-7     Document Type: Review

References (10)

1. Charles LA, Caldas ML, Falk RJ, Terrell RS, Jennette JC. Antibodies against granule proteins activate neutrophils in vitro. J Leukoc Biol. 1991;50:539-46.
2. Minoshima S, Arimura Y, Nakabayashi K, Kitamoto K, Nagasawa T, Ishida A, Suzuki K. Increased release of myeloperoxidase in vitro from neutrophils of patients with myeloperoxidase-specific anti-neutrophil cytoplasmic antibody (MPO-ANCA) related glomerulonephritis. Nephrology. 1997;3:527-34.
3. Arimura Y, Minoshima S, Kamiya K, Tanaka U, Nakabayashi K, Kitamoto K, Nagasawa T, Sakaki T, Suzuki K. Serum myeloperoxidase and serum cytokines in anti-myeloperoxidase antibody-associated glomerulonephritis. Clin Nephrol. 1993;40:256-64.
4. Fujii A, Tomizawa K, Arimura Y, Nagasawa T, Ohashi Y, Hiyama T, Mizuno S, Suzuki K. Epitope analysis of myeloperoxidase specific anti-neutrophil cytoplasmic autoantibodies in MPO-ANCA associated glomerulonephritis. Clin Nephrol. 2000;53:242-52.
5. Kawashima S, Arimura Y, Nakabayashi K, Yamada A. MPO-positive cell and extracellular MPO in glomeruli of MPO-ANCA associated glomerulonephritis. Jpn J Nephrol. 2009;51:56-67.
6. Kawashima S, Arimura Y, Sano K, Kudo A, Komagata Y, Kaname S, Kawakami H, Yamada A: Immunopathologic co-localization of MPO, IgG, and C3 in glomeruli in human MPO-ANCA-associated glomerulonephritis. Clin Nephrol. 2013 (in press).
7. Kessenblock K, Krumbholz M, Schonermarck U, Back W, Gross WL, Werb Z, Grone HJ, Brinkmann V, Jenne DE. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009;15(6):623-5.
8. Haas M, Eustace JA. Immune complex deposits in ANCA-associated crescentic glomerulonephritis: a study of 126 cases. Kidney Int. 2004;65(6):2145-52.
9. Brouwer E, Huitema MG, Klok PA, de Weerd H, Tervaert JW, Weening JJ, Kallenberg CG. Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model. J Exp Med. 1993;177:905-14.
10. Xing GQ, Chen M, Liu G, Heeringa P, Zhang JJ, Zheng X, E J, Kallenberg CG, Zhao MH: Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis. J Clin Immunol. 2009;29(3):282-91.