Maturation of stem cell-derived human heart tissue by mimicking fetal heart rate

Future Cardiology

Volumn 9, Issue 6, 2013, Pages 751-754

  Nunes, Sara S ^a   Miklas, Jason W ^b   Radisic, Milica ^b,c,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

bioengineering; biomimetic; cardiomyocyte; maturation; stem cell

Indexed keywords

ACTIVIN A; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN TYPE 1; DICKKOPF 1 PROTEIN; VASCULOTROPIN;

CARDIAC STEM CELL; CELL DIFFERENTIATION; CELL MATURATION; EMBRYONIC STEM CELL; FETUS HEART RATE; HEART DEVELOPMENT; IN VITRO STUDY; LIVER CELL; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; STEM CELL TRANSPLANTATION;

HEART; HEART RATE, FETAL; HUMANS; MYOCARDIUM; MYOCYTES, CARDIAC; STEM CELLS;

EID: 84887220946     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/fca.13.71     Document Type: Review

References (31)

1. Snir M, Kehat I, Gepstein A et al. Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 285(6), H2355-H2363 (2003).
2. Mcdevitt TC, Laflamme MA, Murry CE. Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway. J. Mol. Cell. Cardiol. 39(6), 865-873 (2005).
3. Mummery C, Ward-Van Oostwaard D, Doevendans P et al. Differentiation of human embryonic stem cells to cardiomyocytes: Role of coculture with visceral endoderm-like cells. Circulation 107(21), 2733-2740 (2003).
4. Dolnikov K, Shilkrut M, Zeevi-Levin N et al. Functional properties of human embryonic stem cell-derived cardiomyocytes: Intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction. Stem Cells 24(2), 236-245 (2006).
5. Dalgetty DM, Medine CN, Iredale JP, Hay DC. Progress and future challenges in stem cell-derived liver technologies. Am. J. Physiol. Gastrointest. Liver Physiol. 297(2), G241-G248 (2009).
6. Nostro MC, Sarangi F, Ogawa S et al. Stage-specific signaling through TGFb family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development 138(5), 861-871 (2011).
7. Yang L, Soonpaa MH, Adler ED et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453(7194), 524-528 (2008).
8. Kattman SJ, Huber TL, Keller GM. Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev. Cell 11(5), 723-732 (2006).
9. Kattman SJ, Witty AD, Gagliardi M et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8(2), 228-240 (2011).
10. Morin KT, Tranquillo RT. Guided sprouting from endothelial spheroids in fibrin gels aligned by magnetic fields and cell-induced gel compaction. Biomaterials 32(26), 6111-6118 (2011).
11. Sander EA, Barocas VH, Tranquillo RT. Initial fiber alignment pattern alters extracellular matrix synthesis in fibroblast-populated fibrin gel cruciforms and correlates with predicted tension. Ann. Biomed. Eng. 39(2), 714-729 (2011).
12. Arduini D. Fetal Cardiac Function. Parthenon Publishing Group, TN, USA, 43-49 (1995).
13. Nunes SS, Miklas JW, Liu J et al. Biowire: A platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat. Methods 10(8), 781-787 (2013).
14. Lieu DK, Fu JD, Chiamvimonvat N et al. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ. Arrhythm. Electrophysiol. 6(1), 191-201 (2013).
15. Stankunas K, Hang CT, Tsun ZY et al. Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev. Cell. 14(2), 298-311 (2008).
16. Patterson M, Chan DN, Ha I et al. Defining the nature of human pluripotent stem cell progeny. Cell Res. 22(1), 178-193 (2012).
17. Tulloch NL, Muskheli V, Razumova MV et al. Growth of engineered human myocardium with mechanical loading and vascular coculture. Circ. Res. 109(1), 47-59 (2011).
18. Foldes G, Mioulane M, Wright JS et al. Modulation of human embryonic stem cell-derived cardiomyocyte growth: A testbed for studying human cardiac hypertrophy J. Mol. Cell. Cardiol. 50(2), 367-376 (2011).
19. Lundy SD, Zhu WZ, Regnier M, Laflamme M. Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells Dev. 22(14), 1991-2002 (2013).
20. Chattergoon NN, Giraud GD, Louey S, Stork P, Fowden AL, Thornburg KL. Thyroid hormone drives fetal cardiomyocyte maturation. FASEB J. 26(1), 397-408 (2012).
21. Mcmullen JR, Shioi T, Huang WY et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J. Biol. Chem. 279(6), 4782-4793 (2004).
22. Bird SD, Doevendans PA, Van Rooijen MA et al. The human adult cardiomyocyte phenotype. Cardiovasc. Res. 58(2), 423-434 (2003).
23. Seif-Naraghi SB, Singelyn JM, Salvatore MA et al. Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction. Sci. Transl. Med. 5(173), 173ra125 (2013).
24. Rodriguez AG, Han SJ, Regnier M, Sniadecki NJ. Substrate stiffness increases twitch power of neonatal cardiomyocytes in correlation with changes in myofibril structure and intracellular calcium. Biophys. J. 101(10), 2455-2464 (2011).
25. Hazeltine LB, Simmons CS, Salick MR et al. Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells. Int. J. Cell Biol. 2012, 508294 (2012).
26. Takebe T, Sekine K, Enomura M et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499(7459), 481-484 (2013).
27. Reinecke H, Zhang M, Bartosek T, Murry CE. Survival, integration, and differentiation of cardiomyocyte grafts: A study in normal and injured rat hearts. Circulation 100(2), 193-202 (1999).
28. Yazawa M, Hsueh B, Jia X et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 471(7337), 230-234 (2011).
29. Moretti A, Bellin M, Welling A et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N. Engl. J. Med. 363(15), 1397-1409 (2010).
30. Carvajal-Vergara X, Sevilla A, D'Souza SL et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465(7299), 808-812 (2010).
31. Sun N, Yazawa M, Liu J et al. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci. Transl. Med. 4(130), 130ra147 (2012).