Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking

OncoTargets and Therapy

Volumn 6, Issue , 2013, Pages 1471-1479

  Tan, Qiang ^a   Wang, Guan ^a   Huang, Jia ^a   Ding, Zhengping ^a   Luo, Qingquan ^a   Mok, Tony ^b   Tao, Qian ^b   Lu, Shun ^a  

^a SHANGHAI CHEST HOSPITAL   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Epigenome; Lung cancer; Methylation; Smoking; Tumor suppressor gene

Indexed keywords

ARAF PROTEIN; CALCIUM; CELL ENZYME; GENOMIC DNA; MITOGEN ACTIVATED PROTEIN KINASE; S6 KINASE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CANCER DIAGNOSIS; CHROMATIN ASSEMBLY AND DISASSEMBLY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC ASSOCIATION; HUMAN; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SMOKING;

EID: 84887214960     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S51041     Document Type: Article

References (28)

1. Tsou JA, Hagen JA, Carpenter CL, Laird-Offringa IA. DNA methylation analysis: a powerful new tool for lung cancer diagnosis. Oncogene. 2002;21:5450-5461.
2. Damiani LA, Yingling CM, Leng S, Romo PE, Nakamura J, Belinsky SA. Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res. 2008;68:9005-9014.
3. Lin RK, Hsieh YS, Lin P, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest. 2010;120:521-532.
4. Liu F, Killian JK, Yang M, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene. 2010;29:3650-3664.
5. Belinsky SA. Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer. 2004;4:707-717.
6. Feng Q, Hawes SE, Stern JE, et al. DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev. 2008;17:645-654.
7. Baryshnikova E, Destro A, Infante MV, et al. Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program. Clin Cancer Res. 2008;14:1913-1919.
8. Monick MM, Beach SR, Plume J, et al. Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet. 2008;159:141-151.
9. Ostrow KL, Hoque MO, Loyo M, et al. Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. Clin Cancer Res. 2010;16:3463-3472.
10. Toyooka S, Maruyama R, Toyooka KO, et al. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer. 2003;103:153-160.
11. Kim DH, Ji YI. Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer. Cancer Res. 2003;63:3743-3746.
12. Li W, Deng J, Jiang P, Tang J. Association of 5′-CpG island hypermethylation of the FHIT gene with lung cancer in southern-central Chinese population. Cancer Biol Ther. 2010;10:997-1000.
13. Tommasi S, Kim S, Zhong XY, Wu XW, Pfeifer GP, Besaratinia A. Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells. PLoS One. 2010;5:e10594.
14. Scesnaite A, Jarmalaite S, Mutanen P, et al. Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure. Mutagenesis. 2011;27:423-429.
15. Hillemacher T, Frieling H, Moskau S, Muschler MA, Semmler A, Kornhuber J. Global DNA methylation is influenced by smoking behaviour. Eur Neuropsychopharmacol. 2008;18:295-298.
16. Shivapurkar SV, Suzuki M. Application of a methylation gene panel by quantitative PCR for lung cancers. Cancer Lett. 2007;247:56-71.
17. Vallbohmer BJ, Yang D. DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value. Clin Lung Cancer. 2006;8:39-44.
18. Kim YT, Sung SW, Kim JH. Can aberrant promoter hypermethylation of CpG islands predict the clinical outcome of non-small cell lung cancer after curative resection? Ann Thorac Surg. 2005;79:1180-1188.
19. Levner I. Feature selection and nearest centroid classification for protein mass spectrometry. BMC Bioinformatics. 2005;6:68.
20. Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13:484-492.
21. De Smet C, Loriot A. DNA hypomethylation in cancer: epigenetic scars of a neoplastic journey. Epigenetics. 2010;5:206-213.
22. Lee W, Jiang ZS, Liu JF, et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature. 2010;465: 473-477.
23. Dhillon AS, Hagan S, Rath O, Kolch W. MAP kinase signalling pathways in cancer. Oncogene. 2007;26:3279-3290.
24. Al-Wadei HA, Schuller HM. Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. J Pathol. 2008;218: 437-445.
25. Masi T, Cekanova M, Walker K, et al. Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms. Genes Chromosomes Cancer. 2005;44:212-217.
26. Misawa K, Ueda Y, Kanazawa T, et al. Epigenetic inactivation of galanin receptor 1 in head and neck cancer. Clin Cancer Res. 2008;14: 7604-7613.
27. Kanazawa T, Kommareddi PK, Iwashita T, et al. Galanin receptor subtype 2 suppresses cell proliferation and induces apoptosis in p53 mutant head and neck cancer cells. Clin Cancer Res. 2009;15:2222-2230.
28. Jackson KJ, Chen X, Miles MF, Harenza J. The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence. Neuropsychopharmacology. 2011;36:2339-2348.