Determination of antazoline hydrochloride in rat plasma and excreta by reversed-phase ion-pair chromatography and its application to pharmacokinetics

Biomedical Chromatography

Volumn 27, Issue 12, 2013, Pages 1595-1602

  Wang, Rui ^a,b   Chu, Yanle ^a   Li, Xiaotian ^a   Wan, Baoluo ^c   Yu, Tong ^a   Wang, Linxi ^a   Hao, Lianqi ^a   Guo, Maowen ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b First Affiliated Hospital of Luohe Medical College   (China)

^c HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Antazoline hydrochloride; Excretion; Pharmacokinetics; Reversed phase ion pair chromatography

Indexed keywords

BODY FLUIDS; EXTRACTION; ION CHROMATOGRAPHY; IONS; PHARMACOKINETICS; PHYSIOLOGY; RECOVERY;

ANALYTICAL METHOD; ANTAZOLINE HYDROCHLORIDE; EXCRETION; INTRAVENOUS INJECTIONS; ION-PAIR CHROMATOGRAPHY; ITS APPLICATIONS; LIQUID-LIQUID EXTRACTION; RAT PLASMA; REVERSED PHASE; REVERSED-PHASE ION PAIR CHROMATOGRAPHY;

RATS;

ACETIC ACID ETHYL ESTER; ANTAZOLINE; PHENACETIN;

ANIMAL EXPERIMENT; ARTICLE; BILE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STABILITY; FECES; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION PAIR CHROMATOGRAPHY; LIMIT OF QUANTITATION; MALE; NONHUMAN; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; URINARY EXCRETION; URINE;

RATTUS;

ANTAZOLINE HYDROCHLORIDE; EXCRETION; PHARMACOKINETICS; REVERSED-PHASE ION PAIR CHROMATOGRAPHY;

ANIMALS; ANTAZOLINE; BILE; CHROMATOGRAPHY, REVERSE-PHASE; FECES; FEMALE; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84887195688     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2965     Document Type: Article

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