Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of Nifurtimox and Benznidazole

Human and Experimental Toxicology

Volumn 32, Issue 12, 2013, Pages 1305-1310

  De Mecca, M M ^a   Bartel, L C ^a   Castro, J A ^a,b  

^a Centro de Investigaciones Toxicologicos   (Argentina)

^b UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

Author keywords

Alcohol drinking; Benznidazole; Liver microsomes; Nifurtimox; Nitroreduction

Indexed keywords

ALCOHOL; BENZNIDAZOLE; CYTOCHROME P450 REDUCTASE; DIPHENYLIODONIUM SALT; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NIFURTIMOX; NITROREDUCTASE;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; METABOLIC RATE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION;

ALCOHOL DRINKING; BENZNIDAZOLE; LIVER MICROSOMES; NIFURTIMOX; NITROREDUCTION;

ALCOHOL DRINKING; ANIMALS; DRUG INTERACTIONS; FEMALE; MALE; MICROSOMES, LIVER; NIFURTIMOX; NITROIMIDAZOLES; NITROREDUCTASES; RATS; RATS, SPRAGUE-DAWLEY; TRYPANOCIDAL AGENTS;

EID: 84887195190     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113485254     Document Type: Article

References (24)

1. Weathermon R and Crabb DW. Alcohol and medication interactions. Alcohol Res Health 1999; 23(1): 40-54.
2. Koski A, Ojanperä I, and Vuori E. Interaction of alcohol and drugs in fatal poisonings. Hum Exp Toxicol 2003; 22(5): 281-287.
3. Klotz U, and Ammon E. Clinical and toxicological consequences of the inductive potential of ethanol. Eur J Clin Pharmacol 1998; 54(1): 7-12.
4. Masana MI, and Rubio MC. Effect of the trypanosomicide benznidazole on various enzymatic systems. Medicina (B Aires) 1983; 43(5): 525-531.
5. Castro JA, Montalto de Mecca M, and Bartel LC. Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis). Human Exper Toxicol 2006; 25: 471-479.
6. Rodrigues Coura J, and de Castro SL. A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz 2002; 97(1): 3-24.
7. Jannin J, and Villa L An overview of Chagas disease treatment. Mem Inst Oswaldo Cruz 2007; 102(Suppl 1): 95-97.
8. De Carli LM and Lieber CS. Fatty liver in the rat after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J Nutr 1967; 91: 331-335.
9. Lieber CS, and De Carli LM. Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol 1989; 24: 197-211.
10. Masana M, de Toranzo EG, and Castro JA. Reductive metabolism and activation of benznidazole. Biochem Pharmacol 1984; 33: 1041-1045.
11. Bartel LC, Montalto deMecca M, Fanelli SL, Rodríguez de Castro C, Díaz EG, and Castro JA. Early nifurtimoxinduced biochemical and ultrastructural alterations in rat heart. Hum Exp Toxicol 2007; 26: 781-788.
12. Díaz EG, de Castro CR, Montalto de Mecca M, and Castro JA. Benznidazole-induced ultrastructural and biochemical alterations in rat colon. Acta Pharmacologica Sinica 2000; 21: 961-966.
13. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
14. Gad SC. Statistics for toxicologists. In: Hayes AW (ed) Principles and methods of toxicology. 4th ed. Philadelphia, PA: Taylor & Francis, 2001, pp. 285-364.
15. McGuire JJ, Anderson DJ, McDonald BJ,Narayanasami R, and Bennett BM. Inhibition of NADPH cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate. Biochem Pharmacol 1998; 56(7): 881-893.
16. Masana M, de Toranzo EGD, and Castro JA. Studies on nifurtimox nitroreductase activity in liver and other rat tissues. Arch Int Pharmacodyn Ther 1984; 270: 4-10.
17. Sasame HA, Castro JA, and Gillette Jr. Studies on the destruction of liver microsomal cytochrome P-450 by carbon tetrachloride administration. Biochem Pharmacol 1968; 17(9): 1759-1768.
18. Lieber CS. Alcohol metabolism: general aspects. In: Watson RR, and Preedy V (eds) Comprehensive handbook of alcohol related pathology. Vol. 1. London, UK: Elsevier Science-Academic Press, 2005, pp. 1211-1222.
19. Waxman DJ, and Holloway MG. Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol 2009; 76(2): 215-228.
20. Song BJ, and Cederbaum AI. Ethanol-inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance: 1996 update. Alcohol Clin Exp Res 1996; 20(8): 138A-146A.
21. Eagon PK. Alcoholic liver injury: influence of gender and hormones. World J Gastroenterol 2010; 16(11): 1377-1384.
22. Colantoni A, La Paglia N, De Maria N, Emanuele MA, Emanuele NV, Idilman R, et al. Influence of sex hormonal status on alcohol-induced oxidative injury in male and female rat liver. Alcohol Clin Exp Res 2000; 24(9): 1467-1473.
23. Quintans LN, Castro GD, and Castro JA. Oxidation of ethanol to acetaldehyde and free radicals by rat testicular microsomes. Arch Toxicol 2005; 79(1): 25-30.
24. Faut M, Rodríguez de Castro C, Bietto FM, Castro JA, and Castro GD. Metabolism of ethanol to acetaldehyde and increased susceptibility to oxidative stress could play a role in the ovarian tissue cell injury promoted by alcohol drinking. Toxicol Ind Health 2009; 25(8): 525-538.