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Volumn 341, Issue 1, 2013, Pages 56-62

Breast cancer stem cells and epithelial mesenchymal plasticity - Implications for chemoresistance

Author keywords

Chemoresistance; Epithelial mesenchymal plasticity; Stem Cells

Indexed keywords

DOXORUBICIN; PACLITAXEL; SALINOMYCIN;

EID: 84887186929     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.06.003     Document Type: Review
Times cited : (94)

References (109)
  • 2
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: a looking glass for cancer?
    • Marusyk A., Almendro V., Polyak K. Intra-tumour heterogeneity: a looking glass for cancer?. Nature Reviews Cancer 2012, 12:323-334.
    • (2012) Nature Reviews Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 4
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?
    • Scheel C., Weinberg R.A. Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?. International Journal of Cancer 2011, 129:2310-2314.
    • (2011) International Journal of Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 5
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nature Reviews Cancer 2008, 8:755-768.
    • (2008) Nature Reviews Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 9
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A., Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2009, 1796:75-90.
    • (2009) Biochimica et Biophysica Acta (BBA) - Reviews on Cancer , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 10
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • Singh A., Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010, 29:4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 11
    • 17844390670 scopus 로고    scopus 로고
    • Will cancer stem cells provide new therapeutic targets?
    • Behbod F., Rosen J.M. Will cancer stem cells provide new therapeutic targets?. Carcinogenesis 2005, 26:703-711.
    • (2005) Carcinogenesis , vol.26 , pp. 703-711
    • Behbod, F.1    Rosen, J.M.2
  • 13
    • 25444495269 scopus 로고    scopus 로고
    • Migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz T., Jung A., Spaderna S., Hlubek F., Kirchner T. Migrating cancer stem cells - an integrated concept of malignant tumour progression. Nature Reviews Cancer 2005, 5:744-749.
    • (2005) Nature Reviews Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 16
    • 34447622988 scopus 로고    scopus 로고
    • Recent translational research: stem cells as the roots of breast cancer
    • Chang C.C. Recent translational research: stem cells as the roots of breast cancer. Breast Cancer Research 2006, 8:103-106.
    • (2006) Breast Cancer Research , vol.8 , pp. 103-106
    • Chang, C.C.1
  • 23
  • 25
    • 34250749646 scopus 로고    scopus 로고
    • Mesenchymal to epithelial transition in development and disease
    • Chaffer C.L., Thompson E.W., Williams E.D. Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 2007, 185:7-19.
    • (2007) Cells Tissues Organs , vol.185 , pp. 7-19
    • Chaffer, C.L.1    Thompson, E.W.2    Williams, E.D.3
  • 26
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • Hay E. An overview of epithelio-mesenchymal transformation. Cells Tissues Organs 1995, 154:8-20.
    • (1995) Cells Tissues Organs , vol.154 , pp. 8-20
    • Hay, E.1
  • 28
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    • Lee J.M., Dedhar S., Kalluri R., Thompson E.W. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. Cell Biology 2006, 172:973-981.
    • (2006) Cell Biology , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 29
    • 0019230340 scopus 로고
    • Cell proliferation and migration on collagen substrata in vitro
    • Schor S.L. Cell proliferation and migration on collagen substrata in vitro. Journal of Cell Science 1980, 41:159-175.
    • (1980) Journal of Cell Science , vol.41 , pp. 159-175
    • Schor, S.L.1
  • 31
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nature Reviews Molecular Cell Biology 2006, 7:131-142.
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 33
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invasive front
    • Christofori G. New signals from the invasive front. Nature 2006, 441:444-450.
    • (2006) Nature , vol.441 , pp. 444-450
    • Christofori, G.1
  • 34
    • 0026781976 scopus 로고
    • Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines
    • Sommers C.L., Heckford S.E., Skerker J.M., Worland P., Torri J.A., Thompson E.W., Byers S.W., Gelmann E.P. Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines. Cancer Research 1992, 52:5190-5197.
    • (1992) Cancer Research , vol.52 , pp. 5190-5197
    • Sommers, C.L.1    Heckford, S.E.2    Skerker, J.M.3    Worland, P.4    Torri, J.A.5    Thompson, E.W.6    Byers, S.W.7    Gelmann, E.P.8
  • 37
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai H., Allen J.T., Mason R.M., Kamimura T., Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respiratory Research 2005, 6:56.
    • (2005) Respiratory Research , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 38
    • 1842527031 scopus 로고    scopus 로고
    • Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm
    • Prindull G., Zipori D. Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm. Blood 2004, 103:2892-2899.
    • (2004) Blood , vol.103 , pp. 2892-2899
    • Prindull, G.1    Zipori, D.2
  • 39
    • 22244492306 scopus 로고    scopus 로고
    • Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?
    • Thompson E.W., Newgreen D.F. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?. Cancer Research 2005, 65:5991-5995.
    • (2005) Cancer Research , vol.65 , pp. 5991-5995
    • Thompson, E.W.1    Newgreen, D.F.2
  • 40
    • 24644487312 scopus 로고    scopus 로고
    • TGF-ß and epithelial-to-mesenchymal transitions
    • Zavadil J., Böttinger E.P. TGF-ß and epithelial-to-mesenchymal transitions. Oncogene 2005, 24:5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 41
    • 55949128465 scopus 로고    scopus 로고
    • Anoikis: a necessary death program for anchorage-dependent cells
    • Chiarugi P., Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochemical Pharmacology 2008, 76:1352-1364.
    • (2008) Biochemical Pharmacology , vol.76 , pp. 1352-1364
    • Chiarugi, P.1    Giannoni, E.2
  • 42
    • 23844528776 scopus 로고    scopus 로고
    • The Snail genes as inducers of cell movement and survival: implications in development and cancer
    • Barrallo-Gimeno A., Nieto M.A. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 2005, 132:3151-3161.
    • (2005) Development , vol.132 , pp. 3151-3161
    • Barrallo-Gimeno, A.1    Nieto, M.A.2
  • 43
    • 34249309574 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace
    • Przybylo J.A., Radisky D.C. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace. International Journal of Biochemistry and Cell Biology 2007, 39:1082-1088.
    • (2007) International Journal of Biochemistry and Cell Biology , vol.39 , pp. 1082-1088
    • Przybylo, J.A.1    Radisky, D.C.2
  • 44
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • Thomson S., Buck E., Petti F., Griffin G., Brown E., Ramnarine N., Iwata K.K., Gibson N., Haley J.D. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Research 2005, 65:9455-9462.
    • (2005) Cancer Research , vol.65 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3    Griffin, G.4    Brown, E.5    Ramnarine, N.6    Iwata, K.K.7    Gibson, N.8    Haley, J.D.9
  • 51
    • 28144440871 scopus 로고    scopus 로고
    • Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells
    • Willipinski-Stapelfeldt B., Riethdorf S., Assmann V., Woelfle U., Rau T., Sauter G., Heukeshoven J., Pantel K. Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clinical Cancer Research 2005, 11:8006-8014.
    • (2005) Clinical Cancer Research , vol.11 , pp. 8006-8014
    • Willipinski-Stapelfeldt, B.1    Riethdorf, S.2    Assmann, V.3    Woelfle, U.4    Rau, T.5    Sauter, G.6    Heukeshoven, J.7    Pantel, K.8
  • 53
    • 77954304397 scopus 로고    scopus 로고
    • Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition
    • Chao Y.L., Shepard C.R., Wells A. Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Molecular Cancer 2010, 9:179.
    • (2010) Molecular Cancer , vol.9 , pp. 179
    • Chao, Y.L.1    Shepard, C.R.2    Wells, A.3
  • 54
    • 84860999602 scopus 로고    scopus 로고
    • Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition
    • Gorges T.M., Tinhofer I., Drosch M., Roese L., Zollner T.M., Krahn T., von Ahsen O. Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC cancer 2012, 12:178.
    • (2012) BMC cancer , vol.12 , pp. 178
    • Gorges, T.M.1    Tinhofer, I.2    Drosch, M.3    Roese, L.4    Zollner, T.M.5    Krahn, T.6    von Ahsen, O.7
  • 56
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B., Tewes M., Fehm T., Hauch S., Kimmig R., Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Research 2009, 11:R46.
    • (2009) Breast Cancer Research , vol.11
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 58
    • 84855987633 scopus 로고    scopus 로고
    • Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells
    • Kasimir-Bauer S., Hoffmann O., Wallwiener D., Kimmig R., Fehm T. Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells. Breast Cancer Research 2012, 14:R15.
    • (2012) Breast Cancer Research , vol.14
    • Kasimir-Bauer, S.1    Hoffmann, O.2    Wallwiener, D.3    Kimmig, R.4    Fehm, T.5
  • 61
    • 84862313107 scopus 로고    scopus 로고
    • BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype
    • Santarosa M., Maestro R. BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype. Cancer and Metastasis Reviews 2011, 31:131-142.
    • (2011) Cancer and Metastasis Reviews , vol.31 , pp. 131-142
    • Santarosa, M.1    Maestro, R.2
  • 62
    • 84856082583 scopus 로고    scopus 로고
    • Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties
    • Sarrio D., Franklin C.K., Mackay A., Reis-Filho J.S., Isacke C.M. Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties. Stem Cells 2012, 30:292-303.
    • (2012) Stem Cells , vol.30 , pp. 292-303
    • Sarrio, D.1    Franklin, C.K.2    Mackay, A.3    Reis-Filho, J.S.4    Isacke, C.M.5
  • 69
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • Visvader J.E. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes and Development 2009, 23:2563-2577.
    • (2009) Genes and Development , vol.23 , pp. 2563-2577
    • Visvader, J.E.1
  • 70
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • DiMeo T.A., Anderson K., Phadke P., Fan C., Perou C.M., Naber S., Kuperwasser C. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Research 2009, 69:5364-5373.
    • (2009) Cancer Research , vol.69 , pp. 5364-5373
    • DiMeo, T.A.1    Anderson, K.2    Phadke, P.3    Fan, C.4    Perou, C.M.5    Naber, S.6    Kuperwasser, C.7
  • 74
    • 77954861745 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer
    • Creighton C.J., Chang J.C., Rosen J.M. Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. Journal of Mammary Gland Biology and Neoplasia 2010, 15:253-260.
    • (2010) Journal of Mammary Gland Biology and Neoplasia , vol.15 , pp. 253-260
    • Creighton, C.J.1    Chang, J.C.2    Rosen, J.M.3
  • 82
  • 83
    • 43949138899 scopus 로고    scopus 로고
    • Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer
    • Coley H.M. Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treatment Reviews 2008, 34:378-390.
    • (2008) Cancer Treatment Reviews , vol.34 , pp. 378-390
    • Coley, H.M.1
  • 86
    • 77952855239 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer
    • Ahmed N., Abubaker K., Findlay J., Quinn M. Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer. Current Cancer Drug Targets 2010, 10:268-278.
    • (2010) Current Cancer Drug Targets , vol.10 , pp. 268-278
    • Ahmed, N.1    Abubaker, K.2    Findlay, J.3    Quinn, M.4
  • 88
    • 62549111693 scopus 로고    scopus 로고
    • The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies
    • Hollier B.G., Evans K., Mani S.A. The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies. Journal of Mammary Gland Biology and Neoplasia 2009, 14:29-43.
    • (2009) Journal of Mammary Gland Biology and Neoplasia , vol.14 , pp. 29-43
    • Hollier, B.G.1    Evans, K.2    Mani, S.A.3
  • 90
    • 33846879160 scopus 로고    scopus 로고
    • Chemotherapy: induction of stress responses
    • Tiligada E. Chemotherapy: induction of stress responses. Endocrine-Related Cancer 2006, 13:S115-S124.
    • (2006) Endocrine-Related Cancer , vol.13
    • Tiligada, E.1
  • 91
    • 65249155400 scopus 로고    scopus 로고
    • Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells
    • Li Q.-Q., Xu J.-D., Wang W.-J., Cao X.-X., Chen Q., Tang F., Chen Z.-Q., Liu X.-P., Xu Z.-D. Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells. Clinical Cancer Research 2009, 15:2657-2665.
    • (2009) Clinical Cancer Research , vol.15 , pp. 2657-2665
    • Li, Q.-Q.1    Xu, J.-D.2    Wang, W.-J.3    Cao, X.-X.4    Chen, Q.5    Tang, F.6    Chen, Z.-Q.7    Liu, X.-P.8    Xu, Z.-D.9
  • 93
    • 4344662447 scopus 로고    scopus 로고
    • Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress
    • Kajita M., McClinic K.N., Wade P.A. Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Molecular and Cellular Biology 2004, 24:7559-7566.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 7559-7566
    • Kajita, M.1    McClinic, K.N.2    Wade, P.A.3
  • 94
    • 33947192053 scopus 로고    scopus 로고
    • Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
    • Cheng G.Z., Chan J., Wang Q., Zhang W., Sun C.D., Wang L.H. Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Research 2007, 67:1979-1987.
    • (2007) Cancer Research , vol.67 , pp. 1979-1987
    • Cheng, G.Z.1    Chan, J.2    Wang, Q.3    Zhang, W.4    Sun, C.D.5    Wang, L.H.6
  • 96
    • 77951248184 scopus 로고    scopus 로고
    • E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells
    • Tryndyak V.P., Beland F.A., Pogribny I.P. E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. International Journal of Cancer 2010, 126:2575-2583.
    • (2010) International Journal of Cancer , vol.126 , pp. 2575-2583
    • Tryndyak, V.P.1    Beland, F.A.2    Pogribny, I.P.3
  • 97
    • 34548217968 scopus 로고    scopus 로고
    • Human breast cancer stem cell markers CD44 and CD24: enriching for cells with functional properties in mice or in man?
    • Fillmore C., Kuperwasser C. Human breast cancer stem cell markers CD44 and CD24: enriching for cells with functional properties in mice or in man?. Breast Cancer Res 2007, 9:303.
    • (2007) Breast Cancer Res , vol.9 , pp. 303
    • Fillmore, C.1    Kuperwasser, C.2
  • 99
    • 37749016965 scopus 로고    scopus 로고
    • Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer
    • Lagasse E. Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer. Gene Therapy 2007, 15:136-142.
    • (2007) Gene Therapy , vol.15 , pp. 136-142
    • Lagasse, E.1
  • 100
  • 102
    • 75849125982 scopus 로고    scopus 로고
    • Breast cancer chemoresistance: emerging importance of cancer stem cells
    • Chuthapisith S., Eremin J., El-Sheemey M., Eremin O. Breast cancer chemoresistance: emerging importance of cancer stem cells. Surgical Oncology 2010, 19:27-32.
    • (2010) Surgical Oncology , vol.19 , pp. 27-32
    • Chuthapisith, S.1    Eremin, J.2    El-Sheemey, M.3    Eremin, O.4
  • 103
    • 58049195459 scopus 로고    scopus 로고
    • Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population
    • Steiniger S.C.J., Coppinger J.A., Krüger J.A., Yates J., Janda K.D. Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population. Stem Cells 2008, 26:3037-3046.
    • (2008) Stem Cells , vol.26 , pp. 3037-3046
    • Steiniger, S.C.J.1    Coppinger, J.A.2    Krüger, J.A.3    Yates, J.4    Janda, K.D.5
  • 104
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., Lander E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 107
    • 77953693899 scopus 로고    scopus 로고
    • Targeting hedgehog - a cancer stem cell pathway
    • Merchant A.A., Matsui W. Targeting hedgehog - a cancer stem cell pathway. Clinical Cancer Research 2010, 16:3130-3140.
    • (2010) Clinical Cancer Research , vol.16 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 108
    • 77953715690 scopus 로고    scopus 로고
    • Targeting Wnt signaling: can we safely eradicate cancer stem cells?
    • Takahashi-Yanaga F., Kahn M. Targeting Wnt signaling: can we safely eradicate cancer stem cells?. Clinical Cancer Research 2010, 16:3153-3162.
    • (2010) Clinical Cancer Research , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 109


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