Nonlinear responses for chromosome and gene level effects induced by vinyl acetate monomer and its metabolite, acetaldehyde in TK6 cells

Environmental and Molecular Mutagenesis

Volumn 54, Issue 9, 2013, Pages 755-768

  Budinsky, Robert ^a   Gollapudi, Bhaskar ^a   Albertini, Richard J ^b   Valentine, Rudolph ^c   Stavanja, Mari ^d   Teeguarden, Justin ^e   Fensterheim, Robert ^f   Rick, David ^a   Lardie, Thomas ^a   Mcfadden, Lisa ^a   Green, Amanda ^g   Recio, Leslie ^g  

^a DOW CHEMICAL COMPANY   (United States)

^b UNIVERSITY OF VERMONT   (United States)

^c DUPONT COMPANY   (United States)

^d Celanese International Corporation   (United States)

^e PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^f RegNet Environmental Services   (United States)

^g ILS   (United States)

Author keywords

Acetaldehyde; Cytotoxicity; Dose response; Genotoxic mode of action; Key events; Rat nasal tumors; Vinyl acetate

Indexed keywords

ACETALDEHYDE; DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MONOMER; PROTEIN; SCHIFF BASE; THYMIDINE KINASE; UNCLASSIFIED DRUG; VINYL ACETATE; VINYL ACETATE MONOMER;

ALLELE; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL CULTURE; CELL FUNCTION; CELL LINE; CHROMOSOME; CONTROLLED STUDY; CYTOTOXICITY; FETAL BOVINE SERUM; GENE; GENE FREQUENCY; GENE LOCUS; GENOTOXICITY; HEATING; HUMAN; HUMAN CELL; HYDROLYSIS; METABOLITE; MICRONUCLEUS; MUTANT; NONLINEAR SYSTEM; NOSE MUCOSA; SERUM;

BOVINAE; EQUIDAE; RATTUS;

EID: 84887186881     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21809     Document Type: Article

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