Clinical characteristics and outcomes of young and very young adults with heart failure: The CHARM programme (candesartan in heart failure assessment of reduction in mortality and morbidity)

Journal of the American College of Cardiology

Volumn 62, Issue 20, 2013, Pages 1845-1854

  Wong, Chih M ^a,b   Hawkins, Nathaniel M ^c   Jhund, Pardeep S ^a   Macdonald, Michael R ^b   Solomon, Scott D ^d   Granger, Christopher B ^e   Yusuf, Salim ^f   Pfeffer, Marc A ^d   Swedberg, Karl ^g   Petrie, Mark C ^b   McMurray, John J V ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b GOLDEN JUBILEE NATIONAL HOSPITAL   (United Kingdom)

^c LIVERPOOL HEART AND CHEST HOSPITAL   (United Kingdom)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f MCMASTER UNIVERSITY   (Canada)

^g UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

ejection fraction; heart failure; outcome; young

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CANDESARTAN; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PLACEBO; SPIRONOLACTONE;

ABNORMAL RESPIRATORY SOUND; ADULT; AGE DISTRIBUTION; AGED; ANGINA PECTORIS; ARTICLE; CARDIOMEGALY; CARDIOVASCULAR MORTALITY; CAUCASIAN; CEREBROVASCULAR ACCIDENT; COMORBIDITY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG TOLERABILITY; DYSPNEA; ETHNIC DIFFERENCE; EVENT FREE SURVIVAL; FEMALE; GROUPS BY AGE; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEPATOMEGALY; HOSPITALIZATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; NEGRO; OBESITY; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PERIPHERAL EDEMA; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SALT INTAKE; SYMPTOMATOLOGY;

ACEI; ANGIOTENSIN RECEPTOR BLOCKER; ANGIOTENSIN-ENZYME CONVERTING INHIBITOR; ARB; CI; CONFIDENCE INTERVAL; EJECTION FRACTION; HAZARD RATIO; HEALTH-RELATED QUALITY OF LIFE; HEART FAILURE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART FAILURE WITH REDUCED EJECTION FRACTION; HF; HF-PEF; HF-REF; HR; HRQL; IDCM; IDIOPATHIC-DILATED CARDIOMYOPATHY; LEFT VENTRICULAR EJECTION FRACTION; LVEF; MINNESOTA LIVING WITH HEART FAILURE; MLWHF; NEW YORK HEART ASSOCIATION; NYHA; OUTCOME; YOUNG;

ADULT; AGED; AUSTRALIA; BENZIMIDAZOLES; CLINICAL TRIALS AS TOPIC; COMORBIDITY; EUROPE; FEMALE; HEART FAILURE; HOSPITALIZATION; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; NORTH AMERICA; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RETROSPECTIVE STUDIES; SOUTH AFRICA; STROKE VOLUME; TETRAZOLES; YOUNG ADULT;

EID: 84887161503     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.05.072     Document Type: Article

References (35)

1. J.G. Cleland, K. Swedberg, and F. Follath The EuroHeart Failure survey programme-a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis Eur Heart J 24 2003 442 463
2. V.L. Roger, A.S. Go, and D.M. Lloyd-Jones Heart disease and stroke statistics-2012 update: a report from the American Heart Association Circulation 125 2012 e2 e220
3. J.G. Cleland, T. McDonagh, A.S. Rigby, A. Yassin, T. Whittaker, and H.J. Dargie The national heart failure audit for England and Wales 2008-2009 Heart 97 2011 876 886
4. U.M. Mogensen, M. Ersboll, and M. Andersen Clinical characteristics and major comorbidities in heart failure patients more than 85 years of age compared with younger age groups Eur J Heart Fail 13 2011 1216 1223
5. P.C. Deedwania, S. Gottlieb, J.K. Ghali, F. Waagstein, and J.C. Wikstrand Efficacy, safety and tolerability of beta-adrenergic blockade with metoprolol CR/XL in elderly patients with heart failure Eur Heart J 25 2004 1300 1309
6. J. Muntwyler, A. Cohen-Solal, N. Freemantle, J. Eastaugh, J.G. Cleland, and F. Follath Relation of sex, age and concomitant diseases to drug prescription for heart failure in primary care in Europe Eur J Heart Fail 6 2004 663 668
7. S.G. Moreno, N. Novielli, and N.J. Cooper Cost-effectiveness of the implantable HeartMate II left ventricular assist device for patients awaiting heart transplantation J Heart Lung Transplant 31 2012 450 458
8. D.P. Mulloy, C.M. Bhamidipati, M.L. Stone, G. Ailawadi, I.L. Kron, and J.A. Kern Orthotopic heart transplant versus left ventricular assist device: a national comparison of cost and survival J Thorac Cardiovasc Surg 145 2013 566 573
9. K. Swedberg, M. Pfeffer, and C. Granger Candesartan in heart failure-assessment of reduction in mortality and morbidity (CHARM): rationale and design. Charm-Programme Investigators J Card Fail 5 1999 276 282
10. J. McMurray, J. Ostergren, and M. Pfeffer Clinical features and contemporary management of patients with low and preserved ejection fraction heart failure: baseline characteristics of patients in the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) programme Eur J Heart Fail 5 2003 261 270
11. M.A. Pfeffer, K. Swedberg, and C.B. Granger Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme Lancet 362 2003 759 766
12. C.B. Granger, J.J. McMurray, and S. Yusuf Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial Lancet 362 2003 772 776
13. J.J. McMurray, J. Ostergren, and K. Swedberg Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial Lancet 362 2003 767 771
14. S. Yusuf, M.A. Pfeffer, and K. Swedberg Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial Lancet 362 2003 777 781
15. B.B. Granger, K. Swedberg, and I. Ekman Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double-blind, randomised, controlled clinical trial Lancet 366 2005 2005 2011
16. S.J. Pocock, D. Wang, and M.A. Pfeffer Predictors of mortality and morbidity in patients with chronic heart failure Eur Heart J 27 2006 65 75
17. K. Bibbins-Domingo, M.J. Pletcher, and F. Lin Racial differences in incident heart failure among young adults N Engl J Med 360 2009 1179 1190
18. N. Townsend, K. Wickramasinghe, and P. Bhatnagar Coronary Heart Disease Statistics 2012 British Heart Foundation London
19. J.G. Cleland, P. Armstrong, and J.D. Horowitz Baseline clinical characteristics of patients recruited into the assessment of treatment with lisinopril and survival study Eur J Heart Fail 1 1999 73 79
20. J.G. Cleland, J.C. Daubert, and E. Erdmann Baseline characteristics of patients recruited into the CARE-HF study Eur J Heart Fail 7 2005 205 214
21. J. Hogenhuis, A.A. Voors, T. Jaarsma, H.L. Hillege, F. Boomsma, and D.J. van Veldhuisen Influence of age on natriuretic peptides in patients with chronic heart failure: a comparison between ANP/NT-ANP and BNP/NT-proBNP Eur J Heart Fail 7 2005 81 86
22. A. Boccanelli, G. Cacciatore, and G.F. Mureddu Baseline characteristics of patients recruited in the AREA IN-CHF study (Antiremodelling Effect of Aldosterone Receptors Blockade with Canrenone in Mild Chronic Heart Failure) J Cardiovasc Med (Hagerstown) 8 2007 683 691
23. J.A. Franciosa, J.J. Nelson, and M.A. Lukas Heart failure in community practice: relationship to age and sex in a beta-blocker registry Congest Heart Fail 12 2006 317 323
24. D. Miani, C. Fresco, and D. Lucci Clinical characteristics, management, and prognosis of octogenarians with acute heart failure admitted to cardiology wards: results from the Italian Survey on Acute Heart Failure Am Heart J 158 2009 126 132
25. M.B. Codd, D.D. Sugrue, B.J. Gersh, and L.J. Melton III Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984 Circulation 80 1989 564 572
26. K. Miura, H. Nakagawa, and Y. Morikawa Epidemiology of idiopathic cardiomyopathy in Japan: results from a nationwide survey Heart 87 2002 126 130
27. C.W. Yancy, G.C. Fonarow, and N.M. Albert Influence of patient age and sex on delivery of guideline-recommended heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF Am Heart J 157 2009 754 762
28. C.M. O'Connor, W.T. Abraham, and N.M. Albert Predictors of mortality after discharge in patients hospitalized with heart failure: an analysis from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) Am Heart J 156 2008 662 673
29. D.E. Forman, C.P. Cannon, A.F. Hernandez, L. Liang, C. Yancy, and G.C. Fonarow Influence of age on the management of heart failure: findings from Get With the Guidelines-Heart Failure (GWTG-HF) Am Heart J 157 2009 1010 1017
30. The effect of digoxin on mortality and morbidity in patients with heart failure. The Digitalis Investigation Group N Engl J Med 336 1997 525 533
31. S.S. Gottlieb, M. Khatta, and E. Friedmann The influence of age, gender, and race on the prevalence of depression in heart failure patients J Am Coll Cardiol 43 2004 1542 1549
32. F.A. Masoudi, J.S. Rumsfeld, and E.P. Havranek Age, functional capacity, and health-related quality of life in patients with heart failure J Card Fail 10 2004 368 373
33. A.V. Ambardekar, G.C. Fonarow, A.F. Hernandez, W. Pan, C.W. Yancy, and M.J. Krantz Characteristics and in-hospital outcomes for nonadherent patients with heart failure: findings from Get With The Guidelines-Heart Failure (GWTG-HF) Am Heart J 158 2009 644 652
34. L. Evangelista, L.V. Doering, K. Dracup, C. Westlake, M. Hamilton, and G.C. Fonarow Compliance behaviors of elderly patients with advanced heart failure J Cardiovasc Nurs 18 2003 197 206
35. F. Formiga, D. Chivite, N. Manito, S. Casas, F. Llopis, and R. Pujol Hospitalization due to acute heart failure. Role of the precipitating factors Int J Cardiol 120 2007 237 241