Engineered extracellular matrix components do not alter the immunomodulatory properties of mesenchymal stromal cells in vitro

Journal of Tissue Engineering and Regenerative Medicine

Volumn 7, Issue 11, 2013, Pages 921-924

  Wehner, Rebekka ^a   Taubert, Christina ^a   Mende, Tanja ^a   Gaebler, Christian ^a   de Andrade, Ana Valeria Gouveia ^b,c   Bornhäuser, Martin ^b,d   Werner, Carsten ^b,e   Tonn, Torsten ^b,c,f   Schäkel, Knut ^g   Bachmann, Michael ^a,b   Schmitz, Marc ^a,b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^c German Red Cross Blood Donation Service East   (Germany)

^d UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^e LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN   (Germany)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^g UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Dendritic cells; Extracellular matrix components; Mesenchymal stromal cells; T lymphocytes

Indexed keywords

CELL CULTURE; CELL ENGINEERING; COLLAGEN; FLOWCHARTING; STEM CELLS; TISSUE; TISSUE ENGINEERING;

CELL TRANSPLANTS; COLLAGEN I; DENDRITIC CELL; DENDRITICS; EXTRACELLULAR MATRIX COMPONENTS; IMMUNOMODULATORY; MESENCHYMAL STROMAL CELLS; PROPERTY; T LYMPHOCYTES; TISSUES ENGINEERINGS;

T-CELLS;

CD3 ANTIBODY; COLLAGEN TYPE 1; FIBRONECTIN; HEPARIN; INTERLEUKIN 12; TROPOCOLLAGEN;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SUBPOPULATION; DENDRITIC CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; MESENCHYME CELL; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; STROMA CELL; TISSUE ENGINEERING;

DENDRITIC CELLS; EXTRACELLULAR MATRIX COMPONENTS; MESENCHYMAL STROMAL CELLS; T LYMPHOCYTES;

ANTIGENS, CD28; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOKINES; EXTRACELLULAR MATRIX PROTEINS; HUMANS; IMMUNOMODULATION; LYMPHOCYTE CULTURE TEST, MIXED; MESENCHYMAL STROMAL CELLS; TISSUE ENGINEERING;

EID: 84887149035     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1500     Document Type: Article

References (15)

1. Arthur A, Zannettino A, Gronthos S. 2009; The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. J Cell Physiol 218: 237-245.
2. Badylak SF, Gilbert TW. 2008; Immune response to biologic scaffold materials. Semin Immunol 20: 109-116.
3. Kundu AK, Putnam AJ. 2006; Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cells. Biochem Biophys Res Commun 347: 347-357.
4. Lanfer B, Seib FP, Freudenberg U, et al. 2009; The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices. Biomaterials 30: 5950-5958.
5. Oswald J, Boxberger S, Jorgensen B, et al. 2004; Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22: 377-384.
6. Pittenger MF, Mackay AM, Beck SC, et al. 1999; Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147.
7. Pompe T, Zschoche S, Herold N, et al. 2003; Maleic anhydride copolymers - a versatile platform for molecular biosurface engineering. Biomacromolecules 4: 1072-1079.
8. Sanchez-Fueyo A, Strom TB. 2011; Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology 140: 51-64.
9. Schäkel K, Kannagi R, Kniep B, et al. 2002; 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells. Immunity 17: 289-301.
10. Schäkel K, von Kietzell M, Hänsel A, et al. 2006; Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes. Immunity 24: 767-777.
11. Seib FP, Müller K, Franke M, et al. 2009; Engineered extracellular matrices modulate the expression profile and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells. Tissue Eng Part A 15: 3161-3171.
12. Singer NG, Caplan AI. 2011; Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol 6: 457-478.
13. Steinman RM, Banchereau J. 2007; Taking dendritic cells into medicine. Nature 449: 419-426.
14. Wehner R, Wehrum D, Bornhauser M, et al. 2009; Mesenchymal stem cells efficiently inhibit the proinflammatory properties o 6-sulfo LacNAc dendritic cells. Haematologica 94: 1151-1156.
15. Zhao S, Wehner R, Bornhauser M, et al. 2010; Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev 19: 607-614.