Staphylococcus aureus protein A promotes immune suppression

mBio

Volumn 4, Issue 5, 2013, Pages

  Kobayashi, Scott D ^a   DeLeo, Frank R ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HEMOLYSIN; B LYMPHOCYTE RECEPTOR; BACTERIAL ANTIGEN; BACTERIAL TOXIN; CP5 ANTIGEN; CP8 ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IRON SURFACE DETERMINANT B; NEUTRALIZING ANTIBODY; STAPHYLOCOCCUS PROTEIN A; STAPHYLOCOCCUS VACCINE; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIBODY PRODUCTION; ARTICLE; BACTERIAL IMMUNITY; BACTERIAL SECRETION SYSTEM; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CELL DEATH; HUMAN; IMMUNE DEFICIENCY; IMMUNE EVASION; IN VITRO STUDY; INFECTION PREVENTION; INNATE IMMUNITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NONHUMAN; OPSONOPHAGOCYTOSIS; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; VACCINATION;

ANIMALIA; BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ADAPTIVE IMMUNITY; ANIMALS; FEMALE; HUMANS; IMMUNE EVASION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCAL PROTEIN A; STAPHYLOCOCCUS AUREUS;

EID: 84887147442     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00764-13     Document Type: Article

References (18)

1. Klevens RM, Morrison MA, Nadle J, Petit S, Gershman K, Ray S, Harrison LH, Lynfield R, Dumyati G, Townes JM, Craig AS, Zell ER, Fosheim GE, McDougal LK, Carey RB, Fridkin SK, Active Bacterial Core surveillance (ABCs) MRSA Investigators. 2007. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298:1763-1771.
2. Moran GJ, Krishnadasan A, Gorwitz RJ, Fosheim GE, McDougal LK, Carey RB, Talan DA, Net, EMERGEncy ID Study Group. 2006. Methicillin-resistant S. aureus infections among patients in the emergency department. N. Engl. J. Med. 355:666-674.
3. Projan SJ. 2008. Whither antibacterial drug discovery? Drug Discov. Today 13:279-280.
4. Jansen KU, Girgenti DQ, Scully IL, Anderson AS. 2013. Vaccine review. Staphylococcus aureus vaccines: problems and prospects. Vaccine 31: 2723-2730.
5. Fowler VG, Allen KB, Moreira ED, Moustafa M, Isgro F, Boucher HW, Corey GR, Carmeli Y, Betts R, Hartzel JS, Chan IS, McNeely TB, Kartsonis NA, Guris D, Onorato MT, Smugar SS, DiNubile MJ, Sobanjo-ter Meulen A. 2013. Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial. JAMA 309:1368-1378.
6. Projan SJ, Nesin M, Dunman PM. 2006. Staphylococcal vaccines and immunotherapy: to dream the impossible dream? Curr. Opin. Pharmacol. 6:473-479.
7. Falugi F, Kim HK, Missiakas DM, Schneewind O. 2013. The role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus. mBio 4(5):e00575-13. doi:10.1128/mBio.00575-13.
8. Dossett JH, Kronvall G, Williams RC, Quie PG. 1969. Antiphagocytic effects of staphylococcal protein A. J. Immunol. 103:1405-1410.
9. Peterson PK, Verhoef J, Sabath LD, Quie PG. 1977. Effect of protein A on staphylococcal opsonization. Infect. Immun. 15:760-764.
10. Romagnani S, Giudizi MG, del Prete G, Maggi E, Biagiotti R, Almerigogna F, Ricci M. 1982. Demonstration on protein A of two distinct immunoglobulin-binding sites and their role in the mitogenic activity of Staphylococcus aureus Cowen I on human B cells. J. Immunol. 129: 596-602.
11. Graille M, Stura EA, Corper AL, Sutton BJ, Taussig MJ, Charbonnier JB, Silverman GJ. 2000. Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity. Proc. Natl. Acad. Sci. U. S. A. 97:5399-5404.
12. Goodyear CS, Silverman GJ. 2003. Death by a B cell superantigen. In vivo VH-targeted apoptotic supraclonal B cell deletion by a staphylococcal toxin. J. Exp. Med. 197:1125-1139.
13. Gorwitz RJ, Kruszon-Moran D, McAllister SK, McQuillan G, McDou-gal LK, Fosheim GE, Jensen BJ, Killgore G, Tenover FC, Kuehnert MJ. 2008. Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004. J. Infect. Dis. 197:1226-1234.
14. Rogers DE, Tompsett R. 1952. The survival of staphylococci within hu-man leukocytes. J. Exp. Med. 95:209-230.
15. Voyich JM, Braughton KR, Sturdevant DE, Whitney AR, Saïd-Salim B, Porcella SF, Long RD, Dorward DW, Gardner DJ, Kreiswirth BN, Musser JM, DeLeo FR. 2005. Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J. Immunol. 175:3907-3919.
16. Rogers DE. 1956. Studies on bacteremia. I. Mechanisms relating to the persistence of bacteremia in rabbits following the intravenous injection of staphylococci. J. Exp. Med. 103:713-742.
17. Shayegani MG, Kapral FA. 1962. The immediate fate of staphylococci after phagocytosis. J. Gen. Microbiol. 29:625-636.
18. Kim HK, Cheng AG, Kim HY, Missiakas DM, Schneewind O. 2010. Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice. J. Exp. Med. 207:1863-1870.