Plasma gelsolin levels are decreased and correlate with fibrosis in IgA nephropathy

Experimental Biology and Medicine

Volumn 238, Issue 11, 2013, Pages 1318-1327

  Han, Changsong ^a   Zhang, Lei ^a   Zhu, Xiaoling ^a   Tang, Jing ^a   Jin, Xiaoming ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

IgA nephropathy; mouse IgA nephropathy model; oxidative stress; Plasma gelsolin; TGF 1

Indexed keywords

CATALASE; GELSOLIN; GLUTATHIONE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN DEPOSITION; KIDNEY FIBROSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY; URINALYSIS; WESTERN BLOTTING;

IGA NEPHROPATHY; MOUSE IGA NEPHROPATHY MODEL; OXIDATIVE STRESS; PLASMA GELSOLIN; TGFΒ1;

ANIMALS; CATALASE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FIBROSIS; GELSOLIN; GLOMERULONEPHRITIS, IGA; GLUTATHIONE; KIDNEY; MALONDIALDEHYDE; MICE; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84887140973     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213503256     Document Type: Article

References (35)

1. D'Amico G.Natural history of idiopathic IgAN: Role of clinical and histological prognostic factors.Am J Kidney Dis. 2000;36:227-37.
2. Yin HL,Stossel TP.Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium dependent regulatory protein.Nature. 1979;281:583-86.
3. Snabes MC,Boyd AE,Bryan J.Detection of actin-binding proteins in human platelets by 125I-actin overlay of polyacrylamide gels.J Cell Biol. 1981;90 (3): 809-12.
4. Harris HE,Bamburg JR,Weeds AG.Actin filament disassembly in blood plasma.FEBS Lett. 1980;121 (1): 175-77.
5. McGough AM,Staiger CJ,Min JK,Simonetti KD.The gelsolin family of actin regulatory proteins: Modular structures, versatile functions.FEBS Lett. 2003;552 (2-3): 75-81.
6. Osborn TM,Verdrengh M,Stossel TP,Tarkowski A,Bokarewa M.Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis.Arthritis Res Ther. 2008;10 (5): 1-9.
7. Bucki R,Levental I,Kulakowska A,Janmey PA.Plasma gelsolin: Function, prognostic value, and potential therapeutic use.Curr Protein Pept Sci. 2008;9:541-51.
8. Suhler E,Lin W,Yin HL,Lee WM.Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis.Crit Care Med. 1997;25:594-98.
9. Mounzer KC,Moncure M,Smith YR,Dinubile MJ.Relationship of admission plasma gelsolin levels to clinical outcomes in patients after major trauma.Am J Respir Crit Care Med. 1999;160:1673-81.
10. DiNubile MJ,Stossel TP,Ljunghusen OC,Ferrara JL,Antin JH.Prognostic implications of declining plasma gelsolin levels after allogeneic stem cell transplantation.Blood. 2002;100:4367-71.
11. Christofidou-Solomidou M,Scherpereel A,Solomides CC,Muzykantov VR,Machtay M,Albelda SM,DiNubile MJ.Changes in plasma gelsolin concentration during acute oxidant lung injury in mice.Lung. 2002;180:91-104.
12. Rothenbach PA,Dahl B,Schwartz JJ,O'Keefe GE,Yamamoto M,Lee WM,Horton JW,Yin HL,Turnage RH.Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction.J Appl Physiol. 2004;96:25-31.
13. Lee PS,Waxman AB,Cotich KL,Chung SW,Perrella MA,Stossel TP.Plasma gelsolin is a marker and therapeutic agent in animal sepsis.Crit Care Med. 2007;35:849-55.
14. Böttinger EP,Bitzer M.TGF-ß signaling in renal disease.J Am Soc Nephrol. 2002;13:2600-10.
15. Sharma R,Khanna A,Sharma M,Savin VJ.Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals.Kidney Int. 2000;58 (1): 131-36.
16. Oikonomou N,Thanasopoulou A,Tzouvelekis A,Harokopos V,Paparountas T,Nikitopoulou I,Witke W,Karameris A,Kotanidou A,Bouros D,Aidinis V.Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis.Thorax. 2009;64:467-75.
17. Chauhan V,Ji L,Chauhan A.Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer's disease.Biogerontology. 2008;9 (6): 381-89.
18. Zhang L,Ye F,He Y,Kong D,Han C,Zhao Z,Zhu J,Liu X,Jin X.Establishment of a mouse IgA nephropathy model with MBP-20-peptide fusion protein.Anat Rec. 2010;293:1729-37.
19. Koyama A,Sharmin S,Sakurai H,Shimizu Y,Hirayama K,Usui J,Nagata M,Yoh K,Yamagata K,Muro K,Kobayashi M,Ohtani K,Shimizu T,Shimizu T.Staphylococcus aureus cell envelope antigen is a new candidate for the induction of IgA nephropathy.Kidney Int. 2004;66:121-32.
20. Livak KJ,Schmittgen TD.Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(t)) method.Methods. 2001;25:402-8.
21. Jennette JC.The immunohistology of IgAN.Am J Kidney Dis. 1988;12:348-52.
22. Miyawaki S,Muso E,Takeuchi E,Matsushima H,Shibata Y,Sasayama S,Yoshida H.Selective breeding for high serum IgA levels from noninbred ddY mice: Isolation of a strain with an early onset of glomerular IgA deposition.Nephron. 1997;76 (2): 201-7.
23. Lee PF,Drager LR,Stossel TP,Moore FD,Rogers SO.Relationship of plasma gelsolin levels in outcomes of critically ill surgical patients.Ann Surg. 2006;243:399-403.
24. Wynn TA,Ramalingam TR.Mechanisms of fibrosis disease: Therapeutic translation for fibrotic.Nat Med. 2013;18 (7): 1028-40.
25. Wynn TA.Cellular and molecular mechanisms of fibrosis.J Pathol. 2008;214:199-210.
26. Wang W,Koka V,Lan HY.Transforming growth factor-beta and Smad signalling in kidney diseases.Nephrology. 2005;10 (1): 48-56.
27. Roberts AB.The ever-increasing complexity of TGF-beta signaling.Cytokine Growth Factor Rev. 2002;13:3-5.
28. Fukasawa H,Yamamoto T,Suzuki H,Togawa A,Ohashi N,Fujigaki Y,Uchida C,Aoki M,Hosono M,Kitagawa M,Hishida A.Treatment with anti-TGF-beta antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-beta signaling.Kidney Int. 2004;65:63-74.
29. Zhou A,Ueno H,Shimomura M,Tanaka R,Shirakawa T,Nakamura H,Matsuo M,Iijima K.Blockade of TGF-beta action ameliorates renal dysfunction and histologic progression in anti-GBM nephritis.Kidney Int. 2003;64:92-101.
30. Grygielko ET,Martin WM,Tweed C,Thornton P,Harling J,Brooks DP,Laping NJ.Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis.J Pharmacol Exp Ther. 2005;313:943-51.
31. Li J,Campanale NV,Liang RJ,Deane JA,Bertram JF,Ricardo SD.Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-β1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy.Am J Pathol. 2006;169:1527-40.
32. Dryden GW,Deaciuc I,Arteel G,McClain CJ.Clinical implications of oxidative stress and antioxidant therapy.Curr Gastroenterol Rep. 2005;7:308-16.
33. Forsberg L,deFaire U,Morgenstern R.Oxidative stress, human genetic variation, and disease.Arch Biochem Biophys. 2001;389:84-93.
34. Chen JX,Zhou JF,Shen HC.Oxidative stress and damage induced by abnormal free radical reactions and IgA nephropathy.J Zhejiang Univ Sci B. 2005;6:61-68.
35. Vas T,Wagner Z,Jenei V,Varga Z,Kovács T,Wittmann I,Schinzel R,Balla G,Balla J,Heidland A,Nagy J.Oxidative stress and non-enzymatic glycation in IgA nephropathy.Clin Nephrol. 2005;64:343-51.