Axon degeneration is key component of neuronal death in amyloid-β toxicity

Neurochemistry International

Volumn 63, Issue 8, 2013, Pages 782-789

  Alobuia, Wilson M ^a   Xia, Wei ^a   Vohra, Bhupinder P S ^a  

^a UNIVERSITY OF CENTRAL ARKANSAS   (United States)

Author keywords

Alzheimer's; Amyloid ; Axon degeneration; Bcl xl; Nmnat

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; PROTEIN BCL XL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GENE OVEREXPRESSION; HIPPOCAMPAL NEURONAL CULTURE; IN VITRO STUDY; MOUSE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALZHEIMER'S; AMYLOID-Β; AXON DEGENERATION; BCL-XL; NMNAT;

AMYLOID BETA-PEPTIDES; ANIMALS; AXONS; CELL DEATH; CELLS, CULTURED; HIPPOCAMPUS; MICE; PEPTIDE FRAGMENTS;

EID: 84887134871     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.08.013     Document Type: Article

References (47)

1. S. Albrecht, N. Bogdanovic, B. Ghetti, B. Winblad, and A.C. LeBlanc Caspase-6 activation in familial Alzheimer disease brains carrying amyloid precursor protein or presenilin I or presenilin II mutations J. Neuropathol. Exp. Neurol. 68 2009 1282 1293
2. T. Araki, Y. Sasaki, and J. Milbrandt Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 2004 1010 1013
3. B. Beirowski, E. Babetto, M.P. Coleman, and K.R. Martin The Wlds gene delays axonal but not somatic degeneration in a rat glaucoma model Eur. J. Neurosci. 28 2008 1166 1179
4. R.E. Burke, and K. O'Malley Axon degeneration in Parkinson's disease Exp. Neurol. 2012 PMID: 22285449
5. Z. Cai, B. Zhao, and A. Ratka Oxidative stress and β-amyloid protein in Alzheimer's disease Neuromol. Med. 13 2011 223 250
6. V. Cavallucci, M. D'Amelio, and F. Cecconi Aβ Toxicity in Alzheimer's Disease Mol. Neurobiol. 45 2012 366 378
7. H.C. Cheng, C.M. Ulane, and R.E. Burke Clinical progression in Parkinson disease and the neurobiology of axons Ann. Neurol. 67 2010 715 725
8. S.M. Chafekar, J.J. Hoozemans, R. Zwart, F. Baas, and W. Scheper A beta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner Antioxid. Redox Signal. 9 2007 2245 2254
9. B.A. Chromy, R.J. Nowak, M.P. Lambert, K.L. Viola, L. Chang, P.T. Velasco, B.W. Jones, S.J. Fernandez, P.N. Lacor, P. Horowitz, C.E. Finch, G.A. Krafft, and W.L. Klein Self-assembly of Abeta(1-42) into globular neurotoxins Biochemistry 42 2003 12749 12760
10. K.N. Dahlgren, A.M. Manelli, W.B. Stine Jr., L.K. Baker, G.A. Krafft, and M.J. LaDu Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability J. Biol. Chem. 277 2002 32046 32053
11. L. Devi, and M. Ohno Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice Neurobiol. Dis. 45 2012 417 424
12. J.T. Finn, M. Weil, F. Archer, R. Siman, A. Srinivasan, and M.C. Raff Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases J. Neurosci. 4 2000 1333 1341
13. I.L. Ferreira, L.M. Bajouco, S.I. Mota, Y.P. Auberson, C.R. Oliveira, and A.C. Rego Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures Cell Calcium 51 2012 95 106
14. A. Ferri, J.R. Sanes, M.P. Coleman, J.M. Cunningham, and A.C. Kato Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease Curr. Biol. 13 2003 669 673
15. A.J. Garcia-Saez The secrets of the Bcl-2 family Cell Death Differ. 11 2012 1733 1740
16. R.K. Graham, D.E. Ehrnhoefer, and M.R. Hayden Caspase-6 and neurodegeneration Trends Neurosci. 34 2011 646 656
17. Y. Gong, L. Chang, K.L. Viola, P.N. Lacor, M.P. Lambert, C.E. Finch, G.A. Krafft, and W.L. Klein Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss Proc. Natl. Acad. Sci. U.S.A. 100 2003 10417 10422
18. A. Itkin, V. Dupres, Y.F. Dufrêne, B. Bechinger, J.M. Ruysschaert, and V. Raussens Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease PLoS One 6 2011 18250 18259
19. N. Kitiyanant, Y. Kitiyanant, C.N. Svendsen, and W. Thangnipon BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons Neurochem. Res. 37 2012 143 152
20. E. Paradis, H. Douillard, M. Koutroumanis, C. Goodyer, and A. LeBlanc Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons J Neurosci 16 1996 7533 7539
21. C.J. Pike, D. Burdick, A.J. Walencewicz, C.G. Glabe, and C.W. Cotman Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state J. Neurosci. 13 1993 1676 1687
22. R. Resende, E. Ferreiro, C. Pereira, and C. Resende de Oliveira Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death Neuroscience 155 2008 725 737
23. C.F. Lippa, L.E. Nee, H. Mori, and P. St George-Hyslop Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease Lancet 352 1998 1117 1118
24. G. Meyer zu Horste, T.A. Miesbach, J.I. Muller, R. Fledrich, R.M. Stassart, B.C. Kieseier, M.P. Coleman, and M.W. Sereda The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration Neurobiol. Dis. 42 2011 1 8
25. A. Nikolaev, T. McLaughlin, D.D. O'Leary, and M. Tessier-Lavigne APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457 2009 981 989
26. R.J. O'Brien, and P.C. Wong Amyloid precursor protein processing and Alzheimer's disease Annu. Rev. Neurosci. 34 2011 185 204
27. Y. Sagot, M. Dubois-Dauphin, S.A. Tan, F. de Bilbao, P. Aebischer, J.C. Martinou, and A.C. Kato Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease J. Neurosci. 11 1995 7727 7733
28. Y. Sasaki, B.P. Vohra, R.H. Baloh, and J. Milbrandt Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo J. Neurosci. 29 2009 6526 6534
29. Y. Sasaki, B.P. Vohra, F.E. Lund, and J. Milbrandt Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide J. Neurosci. 29 2009 5525 5535
30. A.F. Schott, I.J. Apel, G. Nuñez, and M.F. Clarke Bcl-XL protects cancer cells from p53-mediated apoptosis Oncogene 11 1995 1389 1394
31. J.C. Sharpe, D. Arnoult, and R.J. Youle Control of mitochondrial permeability by Bcl-2 family members Biochim. Biophys. Acta. 1644 2004 107 113
32. M. Shoji, T.E. Golde, J. Ghiso, T.T. Cheung, S. Estus, L.M. Shaffer, X.D. Cai, D.M. McKay, R. Tintner, and B. Frangione Production of the Alzheimer amyloid beta protein by normal proteolytic processing Science 258 1992 126 129
33. P.L. Simonian, D.A. Grillot, and G. Nuñez Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death Blood 90 1997 1208 1216
34. Y.S. Song, H.J. Park, S.Y. Kim, S.H. Lee, H.S. Yoo, H.S. Lee, M.K. Lee, K.W. Oh, S.K. Kang, S.E. Lee, and J.T. Hong Protective role of Bcl-2 on beta-amyloid-induced cell death of differentiated PC12 cells: reduction of NF-kappaB and p38 MAP kinase activation Neurosci. Res. 49 2004 69 80
35. S.N. Sivananthan, A.W. Lee, C.G. Goodyer, and A.C. LeBlanc Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures Cell Death Dis. 18 1 2010 100
36. C.M. Sondag, G. Dhawan, and C.K. Combs Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia J. Neuroinflamm. 6 2009 1 13
37. J.R. Stone, D.O. Okonkwo, R.H. Singleton, L.K. Mutlu, G.A. Helm, and J.T. Povlishock Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid Beta peptide in traumatic axonal injury J. Neurotrauma 19 2002 601 614
38. K. Takata, and Y. Kitamura Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: tangle formation, amyloid-β, and microglia in Alzheimer's disease J. Pharmacol. Sci. 118 2012 331 337
39. B. Tizon, E.M. Ribe, W. Mi, C.M. Troy, and E. Levy Cystatin C protects neuronal cells from amyloid-beta-induced toxicity J. Alzheimers Dis. 19 2010 885 894
40. V. Uribe, B.K. Wong, R.K. Graham, C.L. Cusack, N.H. Skotte, M.A. Pouladi, Y. Xie, K. Feinberg, Y. Ou, Y. Ouyang, Y. Deng, S. Franciosi, N. Bissada, A. Spreeuw, W. Zhang, D.E. Ehrnhoefer, K. Vaid, F.D. Miller, M. Deshmukh, D. Howland, and M.R. Hayden Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice Hum. Mol. Genet. 21 2012 1954 1967
41. B.P. Vohra, Y. Sasaki, B.R. Miller, J. Chang, A. DiAntonio, and J. Milbrandt Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway J. Neurosci. 30 2010 13729 13738
42. R.J. Watts, E.D. Hoopfer, and L. Luo Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system Neuron 6 2003 871 885
43. A.V. Whitmore, T. Lindsten, M.C. Raff, and C.B. Thompson The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration Cell Death Differ. 10 2003 260 261
44. T. Yan, Y. Feng, J. Zheng, X. Ge, Y. Zhang, D. Wu, J. Zhao, and Q. Zhai Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity Neurochem. Int. 56 2010 101 106
45. S.G. Younkin The role of A-beta 42 in Alzheimer's disease J. Physiol. Paris 92 1998 289 292
46. Y.W. Zhang, R. Thompson, H. Zhang, and H. Xu APP processing in Alzheimer's disease Mol. Brain 4 2011 3
47. Z.D. Zhou, C.H. Chan, Q.H. Ma, X.H. Xu, Z.C. Xiao, and E.K. Tan The roles of amyloid precursor protein (APP) in neurogenesis: implications to pathogenesis and therapy of Alzheimer disease Cell Adhes. Migr. 5 4 2011 280 292 Jul-Aug