Multiple-capillary measurement of RBC speed, flux, and density with optical coherence tomography

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 11, 2013, Pages 1707-1710

  Lee, Jonghwan ^a   Wu, Weicheng ^a   Lesage, Frederic ^b   Boas, David A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

Author keywords

capillaries; cerebral blood flow measurement; cranial windows; microscopy; optical imaging

Indexed keywords

ANGIOGRAPHY; ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; CAPILLARY; CARDIOVASCULAR PARAMETERS; DENSITY; ERYTHROCYTE; IMAGING SYSTEM; KERNEL METHOD; NONHUMAN; PRIORITY JOURNAL; RAT; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; VELOCITY;

ANIMALS; BLOOD FLOW VELOCITY; BRAIN; CAPILLARIES; CELL COUNT; CEREBRAL ANGIOGRAPHY; CEREBROVASCULAR CIRCULATION; ERYTHROCYTES; RATS; RATS, SPRAGUE-DAWLEY; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84887114740     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.158     Document Type: Article

References (13)

1. Stefanovic B, Hutchinson E, Yakovleva V, Schram V, Russell JT, Belluscio L et al. Functional reactivity of cerebral capillaries. J Cereb Blood Flow Metab 2007; 28: 961-972. (Pubitemid 351589632)
2. Schulte ML, Wood JD, Hudetz AG. Cortical electrical stimulation alters erythrocyte perfusion pattern in the cerebral capillary network of the rat. Brain Res 2003; 963: 81-92. (Pubitemid 36126288)
3. Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N. Oscillating neuro-capillary coupling during cortical spreading depression as observed by tracking of FITClabeled RBCs in single capillaries. Neuroimage 2011; 56: 1001-1010.
4. Kleinfeld D. Cortical blood flow through individual capillaries in rat vibrissa S1 cortex: stimulus-induced changes in flow are comparable to the underlying fluctuations in flow. Int Congress Ser 2002; 1235: 115-122.
5. Huang D, Swanson E, Lin C, Schuman J, Stinson W, Chang W et al. Optical coherence tomography. Science 1991; 254: 1178-1181. (Pubitemid 21917444)
6. Srinivasan VJ, Jiang JY, Yaseen MA, Radhakrishnan H, Wu W, Barry S et al. Rapid volumetric angiography of cortical microvasculature with optical coherence tomography. Opt Lett 2010; 35: 43-45.
7. Kleinfeld D, Mitra PP, Helmchen F, Denk W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci USA 1998; 95: 15741-15746. (Pubitemid 29018770)
8. Kamoun WS, Chae S-S, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA et al. Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nat Methods 2010; 7: 655-660.
9. Lee J, Radhakrishnan H, Wu W, Daneshmand A, Climov M, Ayata C et al. Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography. J Cereb Blood Flow Metab 2013; 33: 819-825.
10. Lee J, Srinivasan V, Radhakrishnan H, Boas DA. Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex. Opt Express 2011; 19: 21258-21270.
11. Villringer A, Them A, Lindauer U, Einhäupl K, Dirnagl U. Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study. Circ Res 1994; 75: 55-62. (Pubitemid 24187735)
12. Hudetz AG, Feher G, Weigle CG, Knuese DE, Kampine JP. Video microscopy of cerebrocortical capillary flow: response to hypotension and intracranial hypertension. Am J Physiol Heart Circ Physiol 1995; 268: H2202-H2210.
13. Klein T, Wieser W, Eigenwillig CM, Biedermann BR, Huber R. Megahertz OCT for ultrawide-field retinal imaging with a 1050nm Fourier domain mode-locked laser. Opt Express 2011; 19: 3044-3062.