Role of Lactobacillus in the prevention of Clostridium difficileassociated diarrhea: A meta-analysis of randomized controlled trials

Chinese Medical Journal

Volumn 126, Issue 21, 2013, Pages 4154-4161

  Wu, Zhi Juan ^a   Du, Xi ^a   Zheng, Jian ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Clostridium difficile; Diarrhea; Lactobacillus; Prevention

Indexed keywords

LACTOBACILLUS VACCINE; PLACEBO;

ARTICLE; BIBLIOGRAPHIC DATABASE; CLINICAL EVALUATION; CLOSTRIDIUM DIFFICILE INFECTION; DATA ANALYSIS; DATA EXTRACTION; DRUG EFFECT; FOLLOW UP; HUMAN; INFORMATION PROCESSING; META ANALYSIS; MORBIDITY; PUBLISHING; QUALITATIVE VALIDITY; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT;

CLOSTRIDIUM DIFFICILE; DIARRHEA; HUMANS; LACTOBACILLUS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84887112669     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20130744     Document Type: Article

References (65)

1. Arvand M, Hauri AM, Zaiss NH, Witte W, Bettge-Weller G. Epidemiology of severe Clostridium difficile infections in Hesse, Germany in 2008-2009. Dtsch Med Wochenschr 2010; 135: 1963-1967
2. Eggertson L. C. difficile hits Sherbrooke, Que, hospital: 100 deaths. CMAJ 2004; 171: 436
3. Oldfield EC 3rd. Clostridium difficile-associated diarrhea: risk factors, diagnostic methods, and treatment. Rev Gastroenterol Disord 2004; 4: 186-195
4. Poutanen SM, Simor AE. Clostridium difficile-associated diarrhea in adults. CMAJ 2004; 171: 51-58
5. Sunenshine RH, McDonald LC. Clostridium difficile-associated disease: new challenges from an established pathogen. Cleve Clin J Med 2006; 73: 187-197
6. Parkes GC, Sanderson JD, Whelan K. The mechanisms and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhoea. Lancet Infect Dis 2009; 9: 237-244
7. Barbut F, Corthier G, Charpak Y, Cerf M, Monteil H, Fosse T, et al. Prevalence and pathogenicity of Clostridium difficile in hospitalized patients. A French multicenter study. Arch Intern Med 1996; 156: 1449-1154
8. Johnston BC, Goldenberg JZ, Vandvik PO, Sun X, Guyatt GH. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 2011; (11): CD004827
9. McFarland LV. Antibiotic-associated diarrhea: epidemiology, trends and treatment. Future Microbiol 2008; 3: 563-578
10. Silva M, Jacobus NV, Deneke C, Gorbach SL. Antimicrobial substance from a human Lactobacillus strain. Antimicrob Agents Chemother 1987; 31: 1231-1233
11. Vanderhoof JA, Young RJ. Use of probiotics in childhood gastrointestinal disorders. J Pediatr Gastroenterol Nutr 1998; 27: 323-332
12. Biller JA, Katz AJ, Flores AF, Buie TM, Gorbach SL. Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG. J Pediatr Gastroenterol Nutr 1995; 21: 224-226
13. Gorbach SL, Chang TW, Goldin BR. Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG. Lancet 1987; 2: 1519
14. Kale-Pradhan PB, Jassal HK, Wilhelm SM. Role of Lactobacillus in the prevention of antibiotic-associated diarrhea: a meta-analysis. Pharmacotherapy 2010; 30: 119-126
15. Ritchie ML, Romanuk TN. A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One 2012; 7: e34938
16. Arvola T, Ruuska T, Keränen J, Hyöty H, Salminen S, Isolauri E. Rectal bleeding in infancy: clinical, allergological, and microbiological examination. Pediatrics 2006; 117: e760-e768
17. Euler AR, Mitchell DK, Kline R, Pickering LK. Prebiotic effect of fructo-oligosaccharide supplemented term infant formula at two concentrations compared with unsupplemented formula and human milk. J Pediatr Gastroenterol Nutr 2005; 40: 157-164
18. Lode H, Von der Höh N, Ziege S, Borner K, Nord CE. Ecological effects of linezolid versus amoxicillin/clavulanic acid on the normal intestinal microflora. Scand J Infect Dis 2001; 33: 899-903
19. Calame W, Weseler AR, Viebke C, Flynn C, Siemensma AD. Gum arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner. Br J Nutr 2008; 100: 1269-1275
20. Orrhage K, Sjöstedt S, Nord CE. Effect of supplements with lactic acid bacteria and oligofructose on the intestinal microflora during administration of cefpodoxime proxetil. J Antimicrob Chemother 2000; 46: 603-612
21. Morrow LE, Kollef MH, Casale TB. Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med 2010; 182: 1058-1064
22. Safety of BB-12 supplemented strawberry yogurt for healthy adults on antibiotics. NCT00848003 at http://www. controlled-trials. com/mrct/trial/490545/
23. Saccharomyces boulardii in irritable bowel syndrome. NCT00589771 at http://www. controlled-trials. com/mrct/trial/411557/
24. The role of synbiotics in reducing post-operative infections in patients undergoing cardiac surgery: a pilot study. NCT00164099 at http://www. controlled-trials. com/mrct/trial/439189/
25. The influence of probiotics on vancomycin-resistant enterococcus. NCT00591474 at http://www. controlled-trials. com/mrct/trial/433653/
26. Abrahamsson TR, Sinkiewicz G, Jakobsson T, Fredrikson M, Björkstén B. Probiotic lactobacilli in breast milk and infant stool in relation to oral intake during the first year of life. J Pediatr Gastroenterol Nutr 2009; 49: 349-354
27. Probiotic Lactobacillus GG to Eliminate VRE Colonization. NCT00756262 at http://www. controlled-trials. com/mrct/trial/461751/
28. Lahtinen SJ, Forssten S, Aakko J, Granlund L, Rautonen N, Salminen S, et al. Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM® modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly. Age (Dordr) 2012; 34: 133-143
29. Wullt M, Johansson Hagslätt ML, Odenholt I, Berggren A. Lactobacillus plantarum 299v enhances the concentrations of fecal short-chain fatty acids in patients with recurrent clostridium difficile-associated diarrhea. Dig Dis Sci 2007; 52: 2082-2086
30. Krämer S, Bischoff SC. Therapeutic possibilities of probiotics in antibiotic-related diarrhea. MMW Fortschr Med 2006; 148: 28-30
31. Probiotics for the Prevention of Major Complications of Cirrhosis. NCT00312910 at http://www. controlled-trials. com/mrct/trial/416795/
32. Song HJ, Kim JY, Jung SA, Kim SE, Park HS, Jeong Y, et al. Effect of probiotic Lactobacillus (Lacidofil® cap) for the prevention of antibiotic-associated diarrhea: a prospective, randomized, double-blind, multicenter study. J Korean Med Sci 2010; 25: 1784-1791
33. Wullt M, Hagslätt ML, Odenholt I. Lactobacillus plantarum 299v for the treatment of recurrent Clostridium difficile-associated diarrhoea: a double-blind, placebo-controlled trial. Scand J Infect Dis 2003; 35: 365-367
34. Lawrence SJ, Korzenik JR, Mundy LM. Probiotics for recurrent Clostridium difficile disease. J Med Microbiol 2005; 54: 905-906
35. Extended treatment with vancomycin for clostridium difficile colitis. NCT00861887 at http://www. controlled-trials. com/mrct/trial/495455/
36. Study of nitazoxanide in the treatment of clostridium difficile colitis. NCT00417872 at http://www. controlled-trials. com/mrct/trial/432627/
37. Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, et al. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 2007; 335: 80
38. Plummer S, Weaver MA, Harris JC, Dee P, Hunter J. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhea. Int Microbiol. 2004; 7: 59-62
39. Probiotics in the prevention of antibiotic-associated and C. difficile diarrhoea. ISRCTN70017204 at http://www. controlled-trials. com/mrct/trial/2287897/
40. Probiotics for clostridium difficile infection in older adults. NCT01680874 at http://www. clinicaltrials. gov/ct2/show/NCT01680874?
41. Anjana Pillai, Richard L Nelson. Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst Rev 2008; (1): CD004611
42. Pochapin M. The effect of probiotics on Clostridium difficile diarrhea. Am J Gastroenterol 2000; 95 (1 Suppl): S11-S13
43. Heimburger DC, Sockwell DG, Geels WJ. Diarrhea with enteral feeding: prospective reappraisal of putative causes. Nutrition 1994; 10: 392-396
44. Qiu J, Zhang DC, Hu L. Research status of probiotics on the prevention and treatment of gastrointestinal infectious disease. Chin J Microecol (Chin) 2007; 19: 474-475
45. Probiotic intervention with elderly subjects. NCT01475942 at http://www. controlled-trials. com/mrct/trial/2159083/
46. The use of probiotics to evaluate colonization with antimicrobial resistant bacteria. NCT01551186 at http://www. clinicaltrials. gov/ct2/show/NCT01551186?
47. Probiotic lactobacillus reuteri to prevent antibiotic-associated diarrhea and Clostridium difficile-related infections in hospitalized children. NCT01295918 at http://www. controlled-trials. com/mrct/trial/1486927/
48. Probiotics for reduction of infections with Clostridium difficile in critically ill patients. NCT01687543 at http://www. clinicaltrials. gov/ct2/show/NCT01687543?
49. Comparison of two formulations of Bio-K. NCT00792844 at http://www. clinicaltrials. gov/ct2/show/NCT00792844?
50. Efficacy and safety of lactobacillus acidophilus/rhamnosus combination for the prevention of antibiotic-associated diarrhea in the elderly. NCT01048567 at http://www. controlled-trials. com/mrct/trial/778407/
51. Addition of lactobacillus to metronidazole in treatment of CDAD. NCT00304863 at http://www. controlled-trials. com/mrct/trial/430289/
52. Efficacy and safety of BIO-K + CL1285 in prevention of antibiotic-associated diarrhea in hospitalized adult patients. NCT00328263 at http://www. controlled-trials. com/mrct/trial/401375/
53. Klarin B, Wullt M, Palmquist I, Molin G, Larsson A, Jeppsson B. Lactobacillus plantarum 299v reduces colonisation of Clostridium difficile in critically ill patients treated with antibiotics. Acta Anaesthesiol Scand 2008; 52: 1096-1102
54. Ruszczyński M, Radzikowski A, Szajewska H. Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic-associated diarrhoea in children. Aliment Pharmacol Ther 2008; 28: 154-162
55. Thomas MR, Litin SC, Osmon DR, Corr AP, Weaver AL, Lohse CM. Lack of effect of Lactobacillus GG on antibiotic-associated diarrhea: a randomized, placebo-controlled trial. Mayo Clin Proc 2001; 76: 883-889
56. Lönnermark E, Friman V, Lappas G, Sandberg T, Berggren A, Adlerberth I. Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics. J Clin Gastroenterol 2010; 44: 106-112
57. Arvola T, Laiho K, Torkkeli S, Mykkänen H, Salminen S, Maunula L, et al. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics 1999; 104: e64
58. Gao XW, Mubasher M, Fang CY, Reifer C, Miller LE. Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients. Am J Gastroenterol 2010; 105: 1636-1641
59. Basu S, Chatterjee M, Ganguly S, Chandra PK. Effect of Lactobacillus rhamnosus GG in persistent diarrhea in Indian children: a randomized controlled trial. J Clin Gastroenterol 2007; 41: 756-760
60. Kale-Pradhan PB, Jassal HK, Wilhelm SM. Role of Lactobacillus in the prevention of antibiotic-associated diarrhea: a meta-analysis. Pharmacotherapy 2010; 30: 119-126
61. McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of clostridium difficile disease. Am J Gastroenterol 2006; 101: 812-822
62. Allori C, Agüero G, de Ruiz Holgado AP, de Nader OM, Perdigon G. Gut mucosa morphology and microflora changes in malnourished mice after renutrition with milk and administration of Lactobacillus casei. J Food Prot 2000; 63: 83-90
63. Hopkins MJ, Macfarlane GT. Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection. J Med Microbiol 2002; 51: 448-454
64. Bezkorovainy A. Probiotics: determinants of survival and growth in the gut. Am J Clin Nutr 2001; 73: 399S-405S
65. Wilson M. Bacteriology of humans: an ecological perspective. Blackwell Publishing: Oxford, UK, 2008