Scanning for cancer genomic changes in plasma: Toward an era of personalized blood-based tumor markers

Clinical Chemistry

Volumn 59, Issue 11, 2013, Pages 1553-1555

  Chan, K C Allen ^a,b,c  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b State Key Laboratory of Oncology   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CA 15-3 ANTIGEN; DNA FRAGMENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOPROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN P53;

BREAST CANCER; BREAST METASTASIS; CANCER DIAGNOSIS; CANCER GENETICS; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER SIZE; CARCINOGENESIS; CHROMOSOME ABERRATION; CIRCULATING TUMOR CELL; DNA DETERMINATION; EARLY CANCER; ENZYME ACTIVE SITE; GENE AMPLIFICATION; GENETIC MARKER; GENOME ANALYSIS; INOPERABLE CANCER; LUNG NON SMALL CELL CANCER; OCCULT CANCER; POINT MUTATION; POISSON DISTRIBUTION; PROTEIN BLOOD LEVEL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; TREATMENT RESPONSE; WILD TYPE;

EID: 84887106523     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2013.207381     Document Type: Review

References (5)

1. Dawson SJ, Tsui DW, Murtaza M, Biggs H, Rueda OM, Chin SF, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 2013;368:1199 -209.
2. Chan KCA, Jiang P, Zheng YW, Liao GJ, Sun H, Wong J, et al. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin Chem 2013;59:211-24.
3. Chan KCA, Hung ECW, Woo JKS, Chan PKS, Leung SF, Lai FPT, et al. Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program. Cancer 2013; 119:1838-44.
4. Murtaza M, Dawson SJ, Tsui DW, Gale D, Forshew T, Piskorz AM, et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013;497:108 -12.
5. Leary RJ, Sausen M, Kinde I, Papadopoulos N, Carpten JD, Craig D, et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl Med 2012;4:162ra154.