RNAtomy of the spliceosome's heart

EMBO Journal

Volumn 32, Issue 21, 2013, Pages 2785-2787

  Bonnal, Sophie ^a,b   Valcárcel, Juan ^a,b,c  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM ION; MESSENGER RNA PRECURSOR; RNA; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA;

ARTICLE; BASE PAIRING; BINDING SITE; INTRON; NONHUMAN; PRIORITY JOURNAL; RNA STRUCTURE; SPLICEOSOME; YEAST;

HUMANS; MODELS, MOLECULAR; RNA, SMALL NUCLEAR; SPLICEOSOMES;

EID: 84887086660     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.213     Document Type: Article

References (10)

1. Anokhina M, Bessonov S, Miao Z, Westhof E, Hartmuth K, Lührmann R (2013) RNA structure analysis of human spliceosomes reveals a 3D arrangement of snRNAs at the catalytic core. The EMBO J 32: 2804-2818
2. Braunschweig U, Gueroussov S, Plocik AM, Graveley BR, Blencowe BJ (2013) Dynamic integration of splicing within gene regulatory pathways. Cell 152: 1252-1269
3. Grainger RJ, Beggs JD (2005) Prp8 protein: at the heart of the spliceosome. RNA 11: 533-557 (Pubitemid 40594322)
4. Jaladat Y, Zhang B, Mohammadi A, Valadkhan S (2011) Splicing of an intervening sequence by protein-free human snRNAs. RNA Biol 8: 372-377
5. Madhani HD, Guthrie C (1992) A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell 71: 803-817
6. Staley JP, Woolford Jr JL (2009) Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines. Curr Opin Cell Biol 21: 109-118
7. Steitz TA, Steitz JA (1993) A general two-metal-ion mechanism for catalytic RNA. Proc Natl Acad Sci USA 90: 6498-6502 (Pubitemid 23207240)
8. Valadkhan S, Manley JL (2001) Splicing-related catalysis by proteinfree snRNAs. Nature 413: 701-707
9. Villa T, Pleiss JA, Guthrie C (2002) Spliceosomal snRNAs: Mg(2\+)-dependent chemistry at the catalytic core? Cell 109: 149-152 (Pubitemid 34518253)
10. Wahl MC, Will CL, Lührmann R (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136: 701-718