Dynamic changes of HBV markers and HBV DNA load in infants born to HBsAg(+) mothers: Can positivity of HBsAg or HBV DNA at birth be an indicator for HBV infection of infants?

BMC Infectious Diseases

Volumn 13, Issue 1, 2013, Pages

  Chen, Tianyan ^a   Wang, Jing ^a   Feng, Yuling ^a   Yan, Zhi ^a   Zhang, Tieying ^a   Liu, Minghui ^b   Bai, Yun ^c   Song, Hongxia ^a   Liu, Hongli ^a   Yang, Yuan ^a   Liu, Jinfeng ^a   He, Yingli ^a   Chen, Yunru ^a   Zhang, Shulin ^a   Zhuang, Guihua ^a   Liang, Xiaofeng ^d   Liu, Zongyin ^e   Xu, Xiaguang ^f   Chen, Wei ^a   Liu, Yong ^a   Zhao, Yingren ^a   more..

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Shaanxi Hangtian Hospital   (China)

^c Shangluo Central Hospital   (China)

^d CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^e Baoji Maternal and Child Care Service Center   (China)

^f ANKANG CENTRAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; VIRUS DNA; BIOLOGICAL MARKER; HEPATITIS B HYPERIMMUNE GLOBULIN; IMMUNOGLOBULIN;

ADULT; ANALYTICAL EQUIPMENT; ANALYZER; ANTIGEN DETECTION; ARTICLE; CHILDBIRTH; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE MARKER; DNA DETERMINATION; EARLY DIAGNOSIS; EXPLORATORY RESEARCH; FEMALE; FOLLOW UP; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MOLECULAR DYNAMICS; MULTICENTER STUDY; NEWBORN; NONHUMAN; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEROCONVERSION; VENOUS BLOOD; VERTICAL TRANSMISSION; VIRUS LOAD; BLOOD; CLINICAL TRIAL; IMMUNOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREVENTION AND CONTROL; VIROLOGY; YOUNG ADULT;

ADULT; BIOLOGICAL MARKERS; DNA, VIRAL; FEMALE; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; HUMANS; IMMUNOGLOBULINS; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84887079262     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-13-524     Document Type: Article

References (16)

1. Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y, et al. Epidemiological serosurvey of hepatitis B in China-declining HBV prevalence due to hepatitis B vaccination. Vaccine 2009, 27:6550-6557. 10.1016/j.vaccine.2009.08.048, 19729084.
2. Shao ZJ, Zhang L, Xu JQ, Xu DZ, Men K, Zhang JX, Cui HC, Yan YP. Mother-to-infant transmission of hepatitis B virus: a Chinese experience. J Med Virol 2011, 83:791-795. 10.1002/jmv.22043, 21360547.
3. Hou J, Liu Z, Gu F. Epidemiology and prevention of hepatitis B virus infection. Int J Med Sci 2005, 2:50-57. 1142225, 15968340.
4. Zhu Q, Yu G, Yu H, Lu Q, Gu X, Dong Z, Zhang X. A randomized control trial on interruption of HBV transmission in uterus. Chin Med J (Engl) 2003, 116:685-687.
5. Shi Z, Yang Y, Ma L, Li X, Schreiber A. Lamivudine in late pregnancy to interrupt in utero transmission of hepatitis B virus: a systematic review and meta-analysis. Obstet Gynecol 2010, 116:147-159. 10.1097/AOG.0b013e3181e45951, 20567182.
6. Sun KX, Li J, Zhu FC, Liu JX, Li RC, Zhai XJ, Li YP, Chang ZJ, Nie JJ, Zhuang H. A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women. Vaccine 2012, 30:5335-5340. 10.1016/j.vaccine.2012.06.036, 22749833.
7. Han GR, Cao MK, Zhao W, Jiang HX, Wang CM, Bai SF, Yue X, Wang GJ, Tang X, Fang ZX. A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection. J Hepatol 2011, 55:1215-1221. 10.1016/j.jhep.2011.02.032, 21703206.
8. Jiang HX, Han GR, Wang CM, Yue X, Wang GJ. Abstract efficacy of combined vaccine for the prevention of HBV transmission in highly viremic HBeAg + mothers and the HBV markers' dynamic change of babies in follow-up. Zhonghua Gan Zang Bing Za Zhi 2011, 19:818-822.
9. Yi W, Li MH, Hu YH, Liu F, Zhang YL, Liu XJ, Hao HX, Song SJ, Liu Y, Li XH, et al. Predictive study of HBsAg in different stages of neonatal venous blood on failure of blocking HBV mother to infant transmission. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2011, 25:338-341.
10. Wang Z, Zhang J, Yang H, Li X, Wen S, Guo Y, Sun J, Hou J. Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. J Med Virol 2003, 71:360-366. 10.1002/jmv.10493, 12966540.
11. Liu Y, Wang CM, Cheng J, Liang ZL, Zhong YW, Ren XQ, Xu ZH, Zoulim F, Xu DP. Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility. Chin Med J (Engl) 2009, 122:1585-1586.
12. Liu J, Li Y, Chen T, Yang Y, Wang K, He Y, Yang Q, Ye F, Jin Y, Qiu T, et al. The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis. Arch Virol 2008, 153:2157-2161. 10.1007/s00705-008-0239-y, 18982245.
13. Yin YZ, Chen XW, Li XM, Hou HY, Shi ZJ. Intrauterine HBV infection: risk factors and impact of HBV DNA. Nan Fang Yi Ke Da Xue Xue Bao 2006, 26:1452-1454.
14. Zhang SL, Yue YF, Bai GQ, Shi L, Jiang H. Mechanism of intrauterine infection of hepatitis B virus. World J Gastroenterol 2004, 10:437-438.
15. Guo Y, Liu J, Meng L, Meina H, Du Y. Survey of HBsAg-positive pregnant women and their infants regarding measures to prevent maternal-infantile transmission. BMC Infect Dis 2010, 10:26. 10.1186/1471-2334-10-26, 2832640, 20156338.
16. Xu DZ, Yan YP, Choi BC, Xu JQ, Men K, Zhang JX, Liu ZH, Wang FS. Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case-control study. J Med Virol 2002, 67:20-26. 10.1002/jmv.2187, 11920813.