Hyperbilirubinemia in pazopanibor sunitinib-treated patients in COMPARZ is associated with UGT1A1 polymorphisms

Annals of Oncology

Volumn 24, Issue 11, 2013, Pages 2927-2928

  Motzer, R J ^a   Johnson, T ^b   Choueiri, T K ^c   Deen, K C ^d   Xue, Z ^d   Pandite, L N ^d   Carpenter, C ^d   Xu, C F ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; GLUCURONOSYLTRANSFERASE 1A1; PAZOPANIB; SUNITINIB; GLUCURONOSYLTRANSFERASE; INDOLE DERIVATIVE; PHARMACOLOGICAL BIOMARKER; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; SULFONAMIDE; UGT1A1 ENZYME;

ADVANCED CANCER; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GILBERT DISEASE; HUMAN; HYPERBILIRUBINEMIA; KIDNEY CARCINOMA; LETTER; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; PHARMACOGENETICS; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UGT1A1 GENE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; LIVER; METABOLISM; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

BILIRUBIN; BIOMARKERS, PHARMACOLOGICAL; GENETIC ASSOCIATION STUDIES; GENOTYPE; GILBERT DISEASE; GLUCURONOSYLTRANSFERASE; HUMANS; HYPERBILIRUBINEMIA; INDOLES; LIVER; PYRIMIDINES; PYRROLES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SULFONAMIDES;

EID: 84887070467     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdt394     Document Type: Letter

References (5)

1. Motzer R, Hutson T, Cella D et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 2013; 369: 722-731.
2. Bosma PJ, Chowdhury JR, Bakker C et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333: 1171-1175.
3. Takeuchi K, Kobayashi Y, Tamaki S et al. Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects. J Gastroenterol Hepatol 2004; 19: 1023-1028.
4. Xu CF, Reck BH, Xue Z et al. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Br J Cancer 2010; 102: 1371-1377.
5. Fujita K, Sugiyama M, Akiyama Y et al. Inhibition of UGT1A1-mediated SN-38 glucuronidation by small molecule of tyrosine kinase inhibitors. Clin Pharmacol Thera 2010; 87: S80.