The elimination half-life of benzodiazepines and fall risk: Two prospective observational studies

Age and Ageing

Volumn 42, Issue 6, 2013, Pages 764-770

  De vries, Oscar J ^a   Peeters, Geeske ^b   Elders, Petra ^a   Sonnenberg, Caroline ^c   Muller, Majon ^a   Deeg, Dorly J H ^a   Lips, Paul ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c GGZ Ingest   (Netherlands)

Author keywords

Accidental falls; Adverse drug events; Aged; Benzodiazepines; Older people; Sedatives

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; CHLORDIAZEPOXIDE; CLOBAZAM; CLONAZEPAM; CLORAZEPATE; DIAZEPAM; FLUNITRAZEPAM; FLURAZEPAM; LORAZEPAM; LORMETAZEPAM; LORPRAZOLAM; NITRAZEPAM; OXAZEPAM; TEMAZEPAM; TRIAZOLAM; UNCLASSIFIED DRUG; ZOLPIDEM; ZOPICLONE;

ACCIDENT PREVENTION; AGED; ARTICLE; COMMUNITY LIVING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; FALL RISK ASSESSMENT; FALLING; FEMALE; HAZARD RATIO; HUMAN; LONGITUDINAL STUDY; MALE; NETHERLANDS; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIDE EFFECT;

ACCIDENTAL FALLS; ADVERSE DRUG EVENTS; AGED; BENZODIAZEPINES; OLDER PEOPLE; SEDATIVES;

ACCIDENTAL FALLS; AGE FACTORS; AGED; AGED, 80 AND OVER; BENZODIAZEPINES; FEMALE; HALF-LIFE; HUMANS; HYPNOTICS AND SEDATIVES; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NETHERLANDS; PATIENT SELECTION; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS;

EID: 84887035530     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/aft089     Document Type: Article

References (29)

1. Tromp AM, Smit JH, Deeg DJ et al Predictors for falls and fractures in the Longitudinal Aging Study Amsterdam. J Bone Miner Res 1998; 13: 1932-9.
2. Tromp AM, Pluijm SM, Smit JH et al Fall-risk screening test: a prospective study on predictors for falls in communitydwelling elderly. J Clin Epidemiol 2001; 54: 837-44.
3. Blake AJ, Morgan K, Bendall MJ et al Falls by elderly people at home: prevalence and associated factors. Age Ageing 1988; 17: 365-72.
4. Stel VS, Smit JH, Pluijm SM, Lips P. Consequences of falling in older men and women and risk factors for health service use and functional decline. Age Ageing 2004; 33: 58-65.
5. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 1999; 47: 30-9.
6. Hartikainen S, Lonnroos E, Louhivuori K. Medication as a risk factor for falls: critical systematic review. J Gerontol A Biol Sci Med Sci 2007; 62: 1172-81.
7. Wagner AK, Zhang F, Soumerai SB et al Benzodiazepine use and hip fractures in the elderly: who is at greatest risk? Arch Intern Med 2004; 164: 1567-72
8. Cumming RG, Le Couteur DG. Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs 2003; 17: 825-37.
9. Panneman MJ, Goettsch WG, Kramarz P, Herings RM. The costs of benzodiazepine-associated hospital-treated fall Injuries in the EU: a Pharmo study. Drugs Aging 2003; 20: 833-9.
10. Bartlett G, Abrahamowicz M, Grad R et al Association between risk factors for injurious falls and new benzodiazepine prescribing in elderly persons. BMC Fam Pract 2009; 10: 1.
11. Gallagher P, Ryan C, Byrne S et al STOPP (Screening Tool of Older Persons' Prescriptions) and START (Screening Tool to Alert Doctors to Right Treatment): consensus validation. Int J Clin Pharm Ther 2008; 46: 72-83.
12. Ray WA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 1989; 262: 3303-7.
13. Vestergaard P, Rejnmark L, Mosekilde L. Anxiolytics and sedatives and risk of fractures: effects of half-life. Calcif Tissue Int 2008; 82: 34-43.
14. Wang PS, Bohn RL, Glynn RJ et al Zolpidem use and hip fractures in older people. J Am Geriatr Soc 2001; 49: 1685-90.
15. Hanlon JT, Boudreau RM, Roumani YF et al Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci 2009; 64: 492-8.
16. Huisman M, Poppelaars J, van der Horst M et al Cohort Profile: The Longitudinal Aging Study Amsterdam. Int J Epidemiol 2001; 40: 868-76.
17. Deeg DJ, van Tilburg T, Smit JH, de Leeuw ED. Attrition in the Longitudinal Aging Study Amsterdam. The effect of differential inclusion in side studies. J Clin Epidemiol 2002; 55: 319-28.
18. Pluijm SM, Smit JH, Tromp EA et al A risk profile for identifying community-dwelling elderly with a high risk of recurrent falling: results of a 3-year prospective study. Osteoporos Int 2006; 17: 417-25.
19. Kellogg International Work Group on the Prevention of Falls by the Elderly. The prevention of falls in later life. Dan Med Bull 1987; 34(Suppl 4): 1-24.
20. WHO Collaborating Centre for Drug Statistics Methodology. http://www.whocc.no/atc_ddd_index/(16 January 2013, date last accessed).
21. Kriegsman DM, Penninx BW, van Eijk JT et al Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients' self-reports and on determinants of inaccuracy. J Clin Epidemiol 1996; 49: 1407-17.
22. Peeters GM, de Vries OJ, Elders PJ et al Prevention of fall incidents in patients with a high risk of falling: design of a randomised controlled trial with an economic evaluation of the effect of multidisciplinary transmural care. BMC Geriatr 2007; 7: 15.
23. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.
24. Zitman FG, Couvee JE. Chronic benzodiazepine use in general practice patients with depression: an evaluation of controlled treatment and taper-off: report on behalf of the Dutch Chronic Benzodiazepine Working Group. Br J Psychiatry 2001; 178: 317-24.
25. Herings RM, Stricker BH, de Boer A, Bakker A, Sturmans F. Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life. Arch Intern Med 1995; 155: 1801-7.
26. Dalleur O, Spinewine A, Henrard S et al Inappropriate prescribing and related hospital admissions in frail older persons according to the STOPP and START criteria. Drugs Aging 2012; 29: 829-37.
27. Ganz DA, Higashi T, Rubenstein LZ. Monitoring falls in cohort studies of community-dwelling older people: effect of the recall interval. J Am Geriatr Soc 2005; 53: 2190-4.
28. de Vries OJ, Peeters GM, Elders PJ et al Multifactorial intervention to reduce falls in older people at high risk of recurrent falls: a randomized controlled trial. Arch Intern Med 2010; 170: 1110-7.
29. Wright RM, Roumani YF, Boudreau R et al Effect of central nervous system medication use on decline in cognition in community-dwelling older adults: findings from the Health, Aging And Body Composition Study. J Am Geriatr Soc 2009; 57: 243-50.