A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function

Journal of Pharmacological and Toxicological Methods

Volumn 69, Issue 1, 2014, Pages 30-38

  Parker, Thomas ^a   Libourel, Paul Antoine ^b   Hetheridge, Malcolm J ^a   Cumming, Robert I ^a   Sutcliffe, Thomas P ^a   Goonesinghe, Alexander C ^a   Ball, Jonathan S ^a   Owen, Stewart F ^a   Chomis, Yann ^c   Winter, Matthew J ^a  

^a ASTRAZENECA   (United Kingdom)

^b LYON NEUROSCIENCE RESEARCH CENTER   (France)

^c View Point   (France)

Author keywords

Alternative animal model; Cardiovascular function; Cardiovascular pharmacology; Drug discovery; Drug safety assessment; Frontloading; Larval zebrafish; Method

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR; CISAPRIDE; HALOPERIDOL; N(G) NITROARGININE METHYL ESTER; NITROPRUSSIDE SODIUM; OUABAIN; POTASSIUM CHANNEL HERG; TERFENADINE; THEOPHYLLINE; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; ATRIOVENTRICULAR BLOCK; BLOOD FLOW; CARDIOVASCULAR FUNCTION; CHRONOTROPISM; CONTROLLED STUDY; EMBRYO; FEMALE; FUNCTIONAL ASSESSMENT; HEART OUTPUT; HEART STROKE VOLUME; IN VIVO STUDY; INOTROPISM; LIQUID CHROMATOGRAPHY; MALE; MORPHOLOGY; MOUSE; NONHUMAN; QRS COMPLEX; TANDEM MASS SPECTROMETRY; ZEBRA FISH;

ANIMALIA; DANIO RERIO; MAMMALIA;

A-V; ABR; ADRENORECEPTOR; ALTERNATIVE ANIMAL MODEL; AR; ATRIAL BEAT RATE; ATRIAL-VENTRICULAR; BEATS PER MINUTE; BLOOD PRESSURE; BP; BPM; CARDIOVASCULAR; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR PHARMACOLOGY; CV; DAYS POST FERTILIZATION; DIMETHYL SULPHOXIDE; DMSO; DPF; DRUG DISCOVERY; DRUG SAFETY ASSESSMENT; FPS; FRAMES PER SECOND; FRONTLOADING; HOUR POST FERTILIZATION; HPF; L-NAME; LARVAL ZEBRAFISH; MAXIMUM TOLERATED CONCENTRATION; METHOD; MS222; MTC; N (G)-NITRO-L-ARGININE METHYL ESTER; SC; SEM; SNP; SODIUM NITROPRUSSIDE; SOLVENT CONTROL; SSV; STANDARD ERROR OF THE MEAN; SURROGATE STROKE VOLUME; TRICAINE METHANESULFONATE; VASCULAR SMOOTH MUSCLE CELLS; VBR; VENTRICULAR BEAT RATE; VSMCS; ZEBRAFISH; ZF;

ANIMALS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; CARDIOVASCULAR SYSTEM; LARVA; MODELS, ANIMAL; REGIONAL BLOOD FLOW; ZEBRAFISH;

EID: 84887012753     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2013.10.002     Document Type: Article

References (37)

1. Bagatto B. Ontogeny of cardiovascular control in zebrafish (Danio rerio): Effects of developmental environment. Comparative Biochemistry and Physiology 2005, 141:391-400.
2. Berghmans S., Butler P., Goldsmith P., Waldron G., Gardner I., Golder Z., et al. Zebrafish based assays for the assessment of cardiac, visual and gut function-Potential safety screens for early drug discovery. Journal of Pharmacology and Toxicology 2008, 58:59-68.
3. Best J.D., Alderton W.K. Zebrafish: An in vivo model for the study of neurological diseases. Journal of Neuropsychiatric Disease and Treatment 2008, 4:567-576.
4. Brodde O.E. Physiology and pharmacology of cardiovascular catecholamine receptors: Implications for treatment of chronic heart failure. American Heart Journal 1990, 120:1565-1572.
5. Conrad K.A., Prosnitz E.H. Cardiovascular effects of theophylline. European Journal of Clinical Pharmacology 1981, 21:109-114.
6. Denvir M.A., Tucker C.S., Mullins J.J. Systolic and diastolic ventricular function in zebrafish embryos: Influence of norepenephrine, MS-222 and temperature. BMC Biotechnology 2008, 8(21). (Epub 2008 Feb 27).
7. Devic E., Xiang Y., Gould D., Kobilka B. Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Molecular Pharmacology 2001, 60:577-583.
8. Dhillon S.S., Dóró E., Magyary I., Egginton S., Sík A., Müller F. Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs. PLoS One 2013, 8(4):e60552.
9. Friederich J.A., Butterworth J.F. Sodium nitroprusside: Twenty years and counting. Anesthesia and Analgesia 1995, 81:152-162.
10. Fritsche R., Schwerte T., Pelster B. Nitric oxide and vascular reactivity in developing zebrafish, Danio rerio. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2000, 279:R2200-R2207.
11. Gore M., Burggren W.W. Cardiac and metabolic physiology of early larval zebrafish (Danio rerio) reflects parental swimming stamina. Frontiers in Physiology 2012, 3(35). (Epub 2012 Feb 24).
12. Grossman E., Messerli F.H. Calcium antagonists. Progress in Cardiovascular Diseases 2004, 47:34-57.
13. Guimarães S., Moura D. Vascular adrenoceptors: An update. Pharmacological Reviews 2001, 53:319-356.
14. Guth B.D. Preclinical cardiovascular risk assessment in modern drug development. Toxicological Sciences 2007, 97:4-20.
15. Holden B.J., Bratt D.G., Chico T.J. Molecular control of vascular development in the zebrafish. Birth Defects Research. Part C, Embryo Today 2011, 93:134-140.
16. Langheinrich U., Vacun G., Wagner T. Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Toxicology and Applied Pharmacology 2003, 193:370-382.
17. Maes J., Verlooy L., Buenafe O.E., de Witte P.A., Esguerra C.V., Crawford A.D. Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae. PLoS ONE 2012, 7(10):e43850.
18. Matthay R.A. Favorable cardiovascular effects of theophylline in COPD. Chest 1987, 92(Suppl. 1):22S-26S.
19. Miano J.M., Georger M.A., Rich A., De Mesy Bentley K.L. Ultrastructure of zebrafish dorsal aortic cells. Zebrafish 2006, 3:455-463.
20. Moore F.B., Hosey M., Bagatto B. Cardiovascular system in larval zebrafish responds to developmental hypoxia in a family specific manner. Frontiers in Zoology 2006, 15(3:4). (Epub 2006 Mar 15).
21. Nemtsas P., Wettwer E., Christ T., Weidinger G., Ravens U. Adult zebrafish heart as a model for human heart? An electrophysiological study. Journal of Molecular and Cellular Cardiology 2010, 48:161-171.
22. Pardo-Martin C., Chang T.Y., Koo B.K., Gilleland C.L., Wasserman S.C., Yanik M.F. High-throughput in vivo vertebrate screening. Nature Methods 2010, 8:634-636.
23. Pelster B., Burggren W.W. Disruption of hemoglobin oxygen transport does not impact oxygen-dependent physiological processes in developing embryos of zebra fish (Danio rerio). Circulation Research 1996, 79:358-362.
24. Santoro M.M., Pesce G., Stainier D.Y. Characterization of vascular mural cells during zebrafish development. Mechanisms of Development 2009, 126:638-649.
25. Schmieder R.E., Messerli F.H., Garavaglia G.E., Nunez B.D. Cardiovascular effects of verapamil in patients with essential hypertension. Circulation 1987, 75:1030-1036.
26. Scholz H. Pharmacological aspects of calcium channel blockers. Cardiovascular Drugs and Therapies 1997, 10(Suppl. 3):869-872.
27. Schwerte T., Pelster B. Digital motion analysis as a tool for analysing the shape and performance of the circulatory system in transparent animals. Journal of Experimental Biology 2000, 203:1659-1669.
28. Shin J.T., Pomerantsev E.V., Mably J.D., MacRae C.A. High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish. Physiological Genomics 2010, 42:300-309.
29. Staudt D., Stainier D. Uncovering the molecular and cellular mechanisms of heart development using the zebrafish. Annual Review of Genetics 2012, 46:397-418.
30. Steele S.L., Yang X., Debiais-Thibaud M., Schwerte T., Pelster B., Ekker M., et al. In vivo and in vitro assessment of cardiac beta-adrenergic receptors in larval zebrafish (Danio rerio). Journal of Experimental Biology 2011, 214:1445-1457.
31. Stevens J.L., Baker T.K. The future of drug safety testing: Expanding the view and narrowing the focus. Drug Discovery Today 2009, 14:162-167.
32. Sugiyama A., Hashimoto K. Effects of gastrointestinal prokinetic agents, TKS159 and cisapride, on the in situ canine heart assessed by cardiohemodynamic and electrophysiological monitoring. Toxicology and Applied Pharmacology 1998, 152:261-269.
33. Sugiyama A., Satoh Y., Hashimoto K. In vivo canine model comparison of cardiohemodynamic and electrophysiological effects of a new antipsychotic drug aripiprazole (OPC-14597) to haloperidol. Toxicology and Applied Pharmacology 2001, 173:120-128.
34. Verkerk A.O., Remme C.A. Zebrafish: A novel research tool for cardiac (patho)electrophysiology and ion channel disorders. Frontiers in Physiology 2012, 3:255. (Epub 2012 Jul 10).
35. Watkins S.C., Maniar S., Mosher M., Roman B.L., Tsang M., St Croix C.M. High resolution imaging of vascular function in zebrafish. PLoS One 2012, 7(8). (Epub 2012 Aug 30).
36. Watts S.W., Morrison S.F., Davis R.P., Barman S.M. Serotonin and blood pressure regulation. Pharmacological Reviews 2012, 64:359-388.
37. Winter M.J., Redfern W.S., Hayfield A.J., Owen S.F., Valentin J., Hutchinson T.H. Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs. Journal of Pharmacological and Toxicological Methods 2008, 57:176-187.