A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells

Mathematical Biosciences

Volumn 246, Issue 1, 2013, Pages 38-46

  Magill, John C ^a   Ciccone, Nick A ^b   Kaiser, Ursula B ^b  

^a PHYSICAL SCIENCES INC   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cell signaling; Control theory; Endocrinology; Mathematical modeling

Indexed keywords

CELL LINES; FOLLICLE STIMULATING HORMONE; KEY CHARACTERISTICS; KEY ELEMENTS; LOW PULSE FREQUENCY; NONLINEAR DIFFERENTIAL EQUATION; REPRODUCTIVE HORMONES; SIGNAL RESPONSE;

CELL CULTURE; CELL SIGNALING; COMPUTER SIMULATION; CONTROL THEORY; DIFFERENTIAL EQUATIONS; ENDOCRINOLOGY; EXPERIMENTS; MATHEMATICAL MODELS;

HORMONES;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; FIREFLY LUCIFERASE; FOLLITROPIN BETA SUBUNIT; GLYCOPROTEIN; GLYCOPROTEIN ALPHA; GONADORELIN; UNCLASSIFIED DRUG;

BIOCHEMISTRY; CELL ORGANELLE; ENDOCRINOLOGY; HORMONE; MUTATION; NUMERICAL MODEL; QUANTITATIVE ANALYSIS; SIGNALING;

ANIMAL CELL; ARTICLE; ESTRUS CYCLE; GENETIC TRANSCRIPTION; GONADOTROPIN SECRETING CELL; HORMONE SYNTHESIS; HYPOPHYSIS CELL; MATHEMATICAL MODEL; MICHAELIS MENTEN KINETICS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

CAMP RESPONSE ELEMENT, A SITE IN A GENE PROMOTER ASSOCIATED WITH THE RESPONSE TO CYCLIC ADENOSINE MONOPHOSPHATE (CAMP); CELL SIGNALING; CONTROL THEORY; CRE; CRE BINDING PROTEIN, A TRANSCRIPTION FACTOR THAT BINDS TO A CRE SITE, MODULATING TRANSCRIPTION OF THE ASSOCIATED GENE; CREB; CREM; ENDOCRINOLOGY; FOLLICLE-STIMULATING HORMONE, A HORMONE PRODUCED BY THE PITUITARY THAT PROMOTES THE GROWTH AND DEVELOPMENT OF FOLLICLES. THE HORMONE IS COMPOSED OF TWO SUBUNITS, Α AND Β; FSH; GENE THAT CODES FOR THE ICER FAMILY OF PROTEINS; GNRH; GONADOTROPHIN-RELEASING-HORMONE; ICER; INDUCIBLE CAMP EARLY REPRESSOR, A PROTEIN INVOLVED IN THE REGULATION OF FSHΒ TRANSCRIPTION; LH; LUTEINIZING HORMONE, A HORMONE PRODUCED BY THE PITUITARY THAT TRIGGERS OVULATION; MATHEMATICAL MODELING;

ANIMALS; COMPUTER SIMULATION; GONADOTROPHS; GONADOTROPIN-RELEASING HORMONE; HUMANS; MODELS, THEORETICAL; SIGNAL TRANSDUCTION;

EID: 84887011193     PISSN: 00255564     EISSN: 18793134     Source Type: Journal    
DOI: 10.1016/j.mbs.2013.09.006     Document Type: Article

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