Inhibition of excessive mitochondrialfissionreduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

Human Molecular Genetics

Volumn 22, Issue 22, 2013, Pages 4545-4561

  Su, Yu Chin ^a   Qi, Xin ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; DYNAMIN I; LEUCINE RICH REPEAT KINASE 2; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P110; REACTIVE OXYGEN METABOLITE; DNM1L PROTEIN, HUMAN; ENZYME INHIBITOR; GUANINE; GUANOSINE TRIPHOSPHATASE; LRRK2 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; NEUROPROTECTIVE AGENT; P110 PEPTIDE; PEPTIDE FRAGMENT; PROTEIN SERINE THREONINE KINASE; SERINE;

ARTICLE; AUTOPHAGY; CELL DAMAGE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FIBROBLAST; FRAGMENTATION REACTION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MUTANT; NERVE CELL DIFFERENTIATION; NERVE CELL LESION; NERVE DEGENERATION; NEURITE; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; HEK293 CELL LINE; HELA CELL LINE; MALE; METABOLISM; MIDDLE AGED; MITOCHONDRIAL DYNAMICS; MOLECULARLY TARGETED THERAPY; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

AUTOPHAGY; ENZYME INHIBITORS; FEMALE; GTP PHOSPHOHYDROLASES; GUANINE; HEK293 CELLS; HELA CELLS; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; MOLECULAR TARGETED THERAPY; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURITES; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SERINE;

EID: 84887004639     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt301     Document Type: Article

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