Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane

Journal of Medical Investigation

Volumn 60, Issue 3-4, 2013, Pages 197-204

  Jambaldorj, Bayasgalan ^a   Terada, Eri ^a   Hosaka, Toshio ^a   Kishuku, Yuka ^a   Tomioka, Yukiko ^a   Iwashima, Kaori ^a   Hirata, Yohko ^a   Teshigawara, Kiyoshi ^a   Le, Chung Thi Kim ^a   Nakagawa, Tadahiko ^a   Harada, Nagakatsu ^a   Sakai, Tohru ^a   Sakaue, Hiroshi ^a   Matsumoto, Toshio ^a   Funaki, Makoto ^b   Takahashi, Akira ^a   Nakaya, Yutaka ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOKUSHIMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cysteine string protein 1; GLUT4; SNARE; VAMP2

Indexed keywords

BINDING PROTEIN; CYSTEINE STRING PROTEIN 1; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; MESSENGER RNA; PALMITIC ACID; SYNAPTOBREVIN 2; SYNTAXIN 4; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CELL FRACTIONATION; CELL MEMBRANE; CELL STRAIN 3T3; COLORIMETRY; CONTROLLED STUDY; ELECTROPORATION; EXPOSURE; GLUCOSE TRANSPORT; IMMUNOPRECIPITATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOLECULAR DOCKING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING; WILD TYPE;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL MEMBRANE; GENE KNOCKDOWN TECHNIQUES; GLUCOSE TRANSPORTER TYPE 4; HSP40 HEAT-SHOCK PROTEINS; INSULIN RESISTANCE; MEMBRANE PROTEINS; MICE; QA-SNARE PROTEINS; RNA, MESSENGER; UP-REGULATION; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

EID: 84886994479     PISSN: 13431420     EISSN: 13496867     Source Type: Journal    
DOI: 10.2152/jmi.60.197     Document Type: Article

References (25)

1. Larance M, Ramm G, James DE: The GLUT4 code. Mol Endocrinol 22: 226-233, 2008
2. Sollner TH: Regulated exocytosis and SNARE function (Review). Mol Membr Biol 20: 209-220, 2003
3. Foster LJ, Klip A: Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells. Am J Physiol Cell Physiol 279: C877-890, 2000
4. Watson RT, Kanzaki M, Pessin JE: Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr Rev 25: 177-204, 2004
5. Evans G J, Morgan A, Burgoyne RD: Tying everything together: the multiple roles of cysteine string protein (CSP) in regulated exocytosis. Traffic 4: 653-659, 2003
6. Chamberlain LH, Graham ME, Kane S, Jackson JL, Maier VH, Burgoyne RD, Gould GW: The synaptic vesicle protein, cysteine-string protein, is associated with the plasma membrane in 3T3-L1 adipocytes and interacts with syntaxin 4. J Cell Sci 114: 445-455, 2001
7. Evans GJ, Barclay JW, Prescott GR, Jo SR, Burgoyne RD, Birnbaum MJ, Morgan A: Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. J Biol Chem 281: 1564-1572, 2006
8. Ranjan R, Bronk P, Zinsmaier KE: Cysteine string protein is required for calcium secretion coupling of evoked neurotransmission in drosophila but not for vesicle recycling. J Neurosci 18: 956-964, 1998
9. Brown H, Larsson O, Branstrom R, Yang SN, Leibiger B, Leibiger I, Fried G, Moede T, Deeney JT, Brown G, Jacobsson G, Rhodes CJ, Braun JE, Scheller RH, Corkey BE, Berggren PO, Meister B: Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J 17: 5048-5058, 1998
10. Zhang H, Kelley WL, Chamberlain LH, Burgoyne RD, Wollheim CB, Lang J: Cysteine-string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes. FEBS Lett 437: 267-272, 1998
11. Chamberlain LH, Burgoyne RD: The cysteine-string domain of the secretory vesicle cysteine-string protein is required for membrane targeting. Biochem J 335: 205-209, 1998
12. Zhang H, Kelley WL, Chamberlain LH, Burgoyne RD, Lang J: Mutational analysis of cysteine-string protein function in insulin exocytosis. J Cell Sci 112: 1345-1351, 1999
13. Zinsmaier KE, Eberle KK, Buchner E, Walter N, Benzer S: Paralysis and early death in cysteine string protein mutants of Drosophila. Science 263: 977-980, 1994
14. Braun JE, Scheller RH: Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles. Neuropharmacology 34: 1361-1369, 1995
15. Boal F, Zhang H, Tessier C, Scotti P, Lang J: The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. Biochemistry 43: 16212-16223, 2004
16. Chamberlain LH, Burgoyne RD: Cysteine string protein functions directly in regulated exocytosis. Mol Biol Cell 9: 2259-2267, 1998
17. Evans GJ, Wilkinson MC, Graham ME, Turner KM, Chamberlain LH, Burgoyne RD, Morgan A:Phosphorylationofcysteinestringprotein by protein kinase A. Implications for the modulation of exocytosis. J Biol Chem 276: 47877-47885, 2001
18. Prescott GR, Jenkins RE, Walsh CM, Morgan A:Phosphorylationofcysteine stringprotein on Serine 10 triggers 14-3-3 protein binding. Biochem Biophys Res Commun 377: 809-814, 2008
19. Hosaka T, Brooks CC, Presman E, Kim SK, Zhang Z, Breen M, Gross DN, Sztul E, Pilch PF: p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin stimulated GLUT4 translocation. Mol Biol Cell 16: 2882-2890, 2005
20. Okada S, Mori M, Pessin JE: Introduction of DNA into 3T3-L1 adipocytes by electroporation. Methods Mol Med 83: 93-96, 2003
21. Huang S, Czech MP: The GLUT4 glucose transporter. Cell Metab 5: 237-252, 2007
22. Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP: Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol 27: 3456-3469, 2007
23. Wilding JP: The importance of free fatty acids in the development of Type 2 diabetes. Diabet Med 24: 934-945, 2007
24. Bai L, Wang Y, Fan J, Chen Y, Ji W, Qu A, Xu P, James DE, Xu T: Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metab 5: 47-57, 2007
25. Lizunov VA, Matsumoto H, Zimmerberg J, Cushman SW, Frolov VA: Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells. J Cell Biol, 169:481-489, 2005