Atheroprotective Krüppel-like factor 4 is downregulated in monocyte subsets of patients with coronary artery disease

Thrombosis and Haemostasis

Volumn 110, Issue 5, 2013, Pages 1080-1082

  Czepluch, Frauke S ^a   Kuschicke, Hendrik ^a   Dellas, Claudia ^a   Riggert, Joachim ^a   Hasenfuss, Gerd ^a   Schäfer, Katrin ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; KRUPPEL LIKE FACTOR 4; TUMOR NECROSIS FACTOR ALPHA;

AGED; CARDIOVASCULAR RISK; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DOWN REGULATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HYPERTENSION; LETTER; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD14; ATHEROSCLEROSIS; CELL SEPARATION; CELLS, CULTURED; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MIDDLE AGED; MONOCYTES; RECEPTORS, IGG; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84886994272     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-05-0367     Document Type: Letter

References (11)

1. Cao Z, Sun X, Icli B, et al. Role of Krüppel-like factors in leukocyte development, function, and disease. Blood 2010; 116: 4404-4414.
2. Hristov M, Weber C. Differential role of monocyte subsets in atherosclerosis. Thromb Haemost 2011; 106: 757-762.
3. Liao X, Sharma N, Kapadia F, et al. Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest 2011; 121: 2736-2749.
4. Sharma N, Lu Y, Zhou G, et al. Myeloid Krüppellike factor 4 deficiency augments atherogenesis in apoE-/-mice-brief report. Arterioscler Thromb Vasc Biol 2012; 32: 2836-2838.
5. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: Their role in infection and inflammation. J Leukoc Biol 2007; 81: 584-592.
6. Nahrendorf M, Swirski FK, Aikawa E, et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007; 204: 3037-3047.
7. Zawada AM, Rogacev KS, Rotter B, et al. Super-SAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 2011; 118: e50-61.
8. Venneri MA, De Palma M, Ponzoni M, et al. Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 2007; 109: 5276-5285.
9. Schirmer SH, Fledderus JO, van der Laan AM, et al. Suppression of inflammatory signaling in monocytes from patients with coronary artery disease. J Mol Cell Cardiol 2009; 46: 177-185.
10. Sivapalaratnam S, Basart H, Watkins NA, et al. Monocyte gene expression signature of patients with early onset coronary artery disease. PLoS One 2012; 7: e32166.
11. Sels JW, Elsenberg EH, Hoefer IE, et al. Fractional flow reserve is not associated with inflammatory markers in patients with stable coronary artery disease. PLoS One 2012; 7: e46356.