Thiamin

Present Knowledge in Nutrition: Tenth Edition

Volumn , Issue , 2012, Pages 261-279

  Bettendorff, Lucien ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Antithiamins, synthetic thiamin antagonists being developed; ThDP cofactor of enzymes, in key metabolic pathways; Thiamin; Thiamin and biochemical lesions, and the way to vitamin discovery; Thiamin deficiency, and beriberi and Wernicke Korsakoff syndrome; Thiamin diphosphate synthesis, and mitochondria transport; Thiamin transport across cell membranes, and specific carriers; Thiamin transport and homeostasis, intestinal uptake, renal loss balance; Thiamin responsive megaloblastic, high affinity thiamin transporter lack; Triphosphorylated derivatives' non cofactor role in metabolic regulation

Indexed keywords

EID: 84886981840     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119946045.ch17     Document Type: Chapter

References (144)

1. Alexander-Kaufman, K. and Harper, C. (2009) Transketolase: observations in alcohol-related brain damage research. Int J Biochem Cell Biol 41, 717-720.
2. Ashokkumar, B., Vaziri, N.D., and Said, H.M. (2006) Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms. Am J Physiol Renal Physiol 291, F796-805.
3. Balaghi, M. and Neal, R.A. (1977) Effect of chronic ethanol administration on thiamin metabolism in the rat. J Nutr 107, 2144-2152.
4. Balaghi, M. and Pearson, W.N. (1966) Tissue and intracellular distribution of radioactive thiamine in normal and thiamine-deficient rats. J Nutr 89, 127-132.
5. Barchi, R.L. and Braun, P.E. (1972) A membrane-associated thiamine triphosphatase from rat brain. Properties of the enzyme. J Biol Chem 247, 7668-7673.
6. Barnerias, C., Saudubray, J.M., Touati, G., et al. (2010) Pyruvate dehydrogenase complex deficiency: four neurological phenotypes with differing pathogenesis. Dev Med Child Neurol 52, e1-9.
7. Bettendorff, L. (1994a) Thiamine in excitable tissues: reflections on a non-cofactor role. Metab Brain Dis 9, 183-209.
8. Bettendorff, L. (1994b) The compartmentation of phosphorylated thiamine derivatives in cultured neuroblastoma cells. Biochim Biophys Acta 1222, 7-14.
9. Bettendorff, L. (1995) Thiamine homeostasis in neuroblastoma cells. Neurochem Int 26, 295-302.
10. Bettendorff, L. and Wins, P. (1994) Mechanism of thiamine transport in neuroblastoma cells. Inhibition of a high affinity carrier by sodium channel activators and dependence of thiamine uptake on membrane potential and intracellular ATP. J Biol Chem 269, 14379-14385.
11. Bettendorff, L., Kolb, H.A., and Schoffeniels, E. (1993) Thiamine triphosphate activates an anion channel of large unit conductance in neuroblastoma cells. J Mem Biol 136, 281-288.
12. Bettendorff, L., Mastrogiacomo, F., Kish, S.J., et al. (1996) Thiamine, thiamine phosphates, and their metabolizing enzymes in human brain. J Neurochem 66, 250-258.
13. Bettendorff, L., Mastrogiacomo, F., Wins, P., et al. (1997) Low thiamine diphosphate levels in brains of patients with frontal lobe degeneration of the non-Alzheimer's type. J Neurochem 69, 2005-2010.
14. Bettendorff, L., Michel-Cahay, C., Grandfils, C., et al. (1987) Thiamine triphosphate and membrane-associated thiamine phosphatases in the electric organ of Electrophorus electricus. J Neurochem 49, 495-502.
15. Bettendorff, L., Peeters, M., Jouan, C., et al. (1991) Determination of thiamin and its phosphate esters in cultured neurons and astrocytes using an ion-pair reversed-phase high-performance liquid chromatographic method. Anal Biochem 198, 52-59.
16. Bettendorff, L., Weekers, L., Wins, P., et al. (1990) Injection of sulbutiamine induces an increase in thiamine triphosphate in rat tissues. Biochem Pharmacol 40, 2557-2560.
17. Bettendorff, L., Wins, P., and Lesourd, M. (1994) Subcellular localization and compartmentation of thiamine derivatives in rat brain. Biochim Biophys Acta 1222, 1-6.
18. Bettendorff, L., Wins, P., and Schoffeniels, E. (1988) Thiamine triphosphatase from Electrophorus electric organ is anion-dependent and irreversibly inhibited by 4,4 ′-diisothiocyanostilbene-2,2'disulfonic acid. Biochem Biophys Res Commun 154, 942-947.
19. Bettendorff, L., Wirtzfeld, B., Makarchikov, A.F., et al. (2007) Discovery of a natural thiamine adenine nucleotide. Nature Chem Biol 3, 211-212.
20. Bizot, J.C., Herpin, A., Pothion, S., et al. (2005) Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuro-Psychopharmacol Biol Psychiatr 29, 928-935.
21. Breslow, R. (1958) On the mechanism of thiamine action. IV.1 Evidence from studies on model systems. J Am Chem Soc 80, 3719-3726.
22. Butterworth, R.F. (1987) Thiamin malnutrition and brain development. In Rassin, D.K., Haber, B., and Drujan, B. (eds)., Basic and Clinical Aspects of Nutrition and Brain Development, Vol. 16. Alan R Liss, New York, pp. 287-304.
23. Butterworth, R.F. (2003) Thiamin deficiency and brain disorders. Nutr Res Rev 16, 277-284.
24. Butterworth, R.F., Gaudreau, C., Vincelette, J., et al. (1991) Thiamine deficiency and Wernicke's encephalopathy in AIDS. Metab Brain Dis 6, 207-212.
25. Carpenter, K.J. (2000) Beriberi, White Rice, and Vitamin B: a Disease, a Cause, and a Cure. University of California Press, Berkeley, CA.
26. Cascante, M., Centelles, J.J., Veech, R.L., et al. (2000) Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. Nutr Cancer 36, 150-154.
27. Casirola, D., Ferrari, G., Gastaldi, G., et al. (1988) Transport of thiamine by brush-border membrane vesicles from rat small intestine. J Physiol 398, 329-339.
28. Chen, M.F., Chen, L.T., Gold, M., et al. (1996) Plasma and erythrocyte thiamin concentrations in geriatric outpatients. J Am Coll Nutr 15, 231-236.
29. Coy, J.F., Dressler, D., Wilde, J., et al. (2005) Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab 51, 257-273.
30. Coy, J.F., Dubel, S., Kioschis, P., et al. (1996) Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes. Genomics 32, 309-316.
31. Czerniecki, J., Chanas, G., Verlaet, M., et al. (2004) Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain. Neuroscience 125, 833-840.
32. Davis, R.E. and Icke, G.C. (1983) Clinical chemistry of thiamin. Adv Clin Chem 23, 93-140.
33. Debs, R., Depienne, C., Rastetter, A., et al. (2010) Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutations. Arch Neurol 67, 126-130.
34. De Caro, L., Rindi, G., and De Giuseppe, L. (1961) Contents in rat tissue of thiamine and its phosphates during dietary thiamine deficiency. Int Z Vitaminforsch 31, 333-340.
35. Depeint, F., Bruce, W.R., Shangari, N., et al. (2006) Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact 163, 94-112.
36. Desjardins, P. and Butterworth, R.F. (2005) Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy. Mol Neurobiol 31, 17-26.
37. Dutta, B., Huang, W., Molero, M., et al. (1999) Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem 274, 31925-31929.
38. Eder, L., Hirt, L., and Dunant, Y. (1976) Possible involvement of thiamine in acetylcholine release. Nature 264, 186-188.
39. Eijkman, C. (1990) Report of the investigations carried out in the laboratory of pathology and bacteriology, Weltevreden, during the year 189. VI. Polyneuritis in chickens. New contributions to the etiology of the disease. 1896. Nutr Rev 48, 243-246.
40. Eudy, J.D., Spiegelstein, O., Barber, R.C., et al. (2000) Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab 71, 581-590.
41. Fattal-Valevski, A., Kesler, A., Sela, B.A., et al. (2005) Outbreak of life-threatening thiamine deficiency in infants in Israel caused by a defective soy-based formula. Pediatrics 115, e233-e238.
42. Fayol, V. (1997) High-performance liquid chromatography determination of total thiamin in biological and food products. Methods Enzymol 279, 57-66.
43. Fleming, J.C., Steinkamp, M.P., Kawatsuji, R., et al. (2001) Characterization of a murine high-affinity thiamine transporter, Slc19a2. Mol Genet Metab 74, 273-280.
44. Fleming, J.C., Tartaglini, E., Steinkamp, M.P., et al. (1999) The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nature Genet 22, 305-308.
45. Foulon, V., Antonenkov, V.D., Croes, K., et al. (1999) Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids. Proc Natl Acad Sci 96, 10039-10044.
46. Frédérich, M., Delvaux, D., Gigliobianco, T., et al. (2009) Thiaminylated adenine nucleotides. Chemical synthesis, structural characterization and natural occurrence FEBS J 276, 3256-3268.
47. Fujiwara, M., Watanabe, H., and Katsui, K. (1954) Allithiamine, a newly found derivative of vitamin B1. J Biochem 41, 29-39.
48. Fukuwatari, T., Yoshida, E., Takahashi, K., et al. (2010) Effect of fasting on the urinary excretion of water-soluble vitamins in humans and rats. J Nutr Sci Vitaminol (Tokyo) 56, 19-26.
49. Gangolf, M., Czerniecki, J., Radermecker, M., et al. (2010a) Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS One 5, e13616. Gangolf, M., Wins, P., Thiry, M., et al. (2010b) Thiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chain. J Biol Chem 285, 583-594.
50. Gastaldi, G., Casirola, D., Ferrari, G., et al. (1989) Effect of chronic ethanol administration on thiamine transport in microvillous vesicles of rat small intestine. Alcohol Alcohol 24, 83-89.
51. Gastaldi, G., Cova, E., Verri, A., et al. (2000) Transport of thiamin in rat renal brush border membrane vesicles. Kidney Int 57, 2043-2054.
52. Gastaldi, G., Laforenza, U., Ferrari, G., et al. (1992) Age-related thiamin transport by small intestinal microvillous vesicles of rat. Biochim Biophys Acta 1105, 271-277.
53. Gigliobianco, T., Lakaye, B., Makarchikov, A.F., et al. (2008) Adenylate kinase-independent thiamine triphosphate accumulation under severe energy stress in Escherichia coli. BMC Microbiol 8, 16.
54. Gigliobianco, T., Lakaye, B., Wins, P., et al. (2010) Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress. BMC Microbiol 10, 148.
55. Gold, M., Chen, M.F., and Johnson, K. (1995) Plasma and red blood cell thiamine deficiency in patients with dementia of the Alzheimer's type. Arch Neurol 52, 1081-1086.
56. Greenwood, J., Love, E.R., and Pratt, O.E. (1982) Kinetics of thiamine transport across the blood-brain barrier in the rat. J Physiol 327, 95-103.
57. Greenwood, J., Luthert, P.J., Pratt, O.E., et al. (1986) Transport of thiamin across the blood-brain barrier of the rat in the absence of aerobic metabolism. Brain Res 399, 148-151.
58. Grijns, G. (1901) Over polyneuritis gallinarum. I. Geneeskundig Tijdschr Nederlandsch Indi ë 41, 3-110.
59. Guerrini, I., Thomson, A.D., Cook, C.C., et al. (2005) Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). Am J Med Genet B Neuropsychiatr Genet 137B, 17-19.
60. Hammes, H.P., Du, X., Edelstein, D., et al. (2003) Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Med 9, 294-299.
61. Harper, C. (1998) The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 57, 101-110.
62. Harper, C. (2009) The neuropathology of alcohol-related brain damage. Alcohol Alcohol 44, 136-140.
63. Hazell, A.S. and Butterworth, R.F. (2009) Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation. Alcohol Alcohol 44, 141-147.
64. Heroux, M. and Butterworth, R.F. (1995) Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy. Neurochem Res 20, 87-93.
65. Heroux, M., Raghavendra Rao, V.L., Lavoie, J., et al. (1996) Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease. Metab Brain Dis 11, 81-88.
66. Horman, I. and Brambilla, E. (1982) The alleged antithiamine activity of o-diphenols: an artefact of oxygen in the thiochrome method? Int J Vitaminol Nutr Res 52, 134-142.
67. Ishii, K., Sarai, K., Sanemori, H., et al. (1979) Concentrations of thiamine and its phosphate esters in rat tissues determined by high-performance liquid chromatography. J Nutr Sci Vitaminol (Tokyo) 25, 517-523.
68. Jansen, B.C.P. and Donath, W.F. (1926) On the isolation of anti-beriberi vitamin. Proc Koninklijke Ned Akad Wetensch 29, 1390-1400.
69. Jenkins, A.H., Schyns, G., Potot, S., et al. (2007) A new thiamin salvage pathway. Nat Chem Biol 3, 492-497.
70. Jurgenson, C.T., Begley, T.P., and Ealick, S.E. (2009) The structural and biochemical foundations of thiamin biosynthesis. Annu Rev Biochem 78, 569-603.
71. Kawasaki, T. (1992) Vitamin B1: Thiamine. In A.P. De Leenheer, W.E. Lambert, and H.J. Nelis (eds), Modern Chromatographic Analysis of Vitamins, Vol. 60. Marcel Dekker, New York, pp. 319-354.
72. Kono, S., Miyajima, H., Yoshida, K., et al. (2009) Mutations in a thiamine-transporter gene and Wernicke's-like encephalopathy. New Engl J Med 360, 1792-1794.
73. Kopelman, M.D., Thomson, A.D., Guerrini, I., et al. (2009) The Korsakoff syndrome: clinical aspects, psychology and treatment. Alcohol Alcohol 44, 148-154.
74. Korner, R.W., Vierzig, A., Roth, B., et al. (2009) Determination of thiamin diphosphate in whole blood samples by high-performance liquid chromatography-a method suitable for pediatric diagnostics. J Chromatogr B 877, 1882-1886.
75. Laforenza, U., Patrini, C., Alvisi, C., et al. (1997) Thiamine uptake in human intestinal biopsy specimens, including observations from a patient with acute thiamine deficiency. Am J Clin Nutr 66, 320-326.
76. Laforenza, U., Patrini, C., Gastaldi, G., et al. (1990) Effects of acute and chronic ethanol administration on thiamine metabolizing enzymes in some brain areas and in other organs of the rat. Alcohol Alcohol 25, 591-603.
77. Lakaye, B., Makarchikov, A.F., Antunes, A.F., et al. (2002) Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. J Biol Chem 277, 13771-13777.
78. Lakaye, B., Wirtzfeld, B., Wins, P., et al. (2004) Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation. J Biol Chem 279, 17142-17147.
79. Lindhurst, M.J., Fiermonte, G., Song, S., et al. (2006) Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci USA 103, 15927-15932.
80. Lockman, P.R., Mumper, R.J., and Allen, D.D. (2003) Evaluation of blood-brain barrier thiamine efflux using the in situ rat brain perfusion method. J Neurochem 86, 627-634.
81. Lonsdale, D., Shamberger, R.J., and Audhya, T. (2002) Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuroendocrinol Lett 23, 303-308.
82. Lumeng, L., Edmondson, J.W., Schenker, S., et al. (1979) Transport and metabolism of thiamin in isolated rat hepatocytes. J Biol Chem 254, 7265-7268.
83. Makarchikov, A.F., Brans, A., and Bettendorff, L. (2007) Thiamine diphosphate adenylyl transferase from E. coli : functional characterization of the enzyme synthesizing adenosine thiamine triphosphate BMC Biochemistry 8, 17.
84. Makarchikov, A.F., Lakaye, B., Gulyai, I.E., et al. (2003) Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cell Mol Life Sci 60, 1477-1488.
85. Marobbio, C.M., Vozza, A., Harding, M., et al. (2002) Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate. EMBO J 21, 5653-5661.
86. Mastrogiacomo, F., Bettendorff, L., Grisar, T., et al. (1996a) Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease. Ann Neurol 39, 585-591.
87. Mastrogiacomo, F., Lindsay, J.G., Bettendorff, L., et al. (1996b) Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. Ann Neurol 39, 592-598.
88. McCool, B.A., Plonk, S.G., Martin, P.R., et al. (1993) Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals. J Biol Chem 268, 1397-1404.
89. McCourt, J.A., Nixon, P.F., and Duggleby, R.G. (2006) Thiamin nutrition and catalysis-induced instability of thiamin diphosphate. Br J Nutr 96, 636-638.
90. McGready, R., Simpson, J.A., Cho, T., et al. (2001) Postpartum thiamine deficiency in a Karen displaced population. Am J Clin Nutr, 74, 808-813.
91. Molina, J.A., Jimenez-Jimenez, F.J., Hernanz, A., et al. (2002) Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease. J Neural Transm 109, 1035-1044.
92. Mukherjee, A.B., Svoronos, S., Ghazanfari, A., et al. (1987) Transketolase abnormality in cultured fibroblasts from familial chronic alcoholic men and their male offspring. J Clin Invest 79, 1039-1043.
93. Nabokina, S.M., Reidling, J.C., and Said, H.M. (2005) Differentiation-dependent up-regulation of intestinal thiamin uptake: cellular and molecular mechanisms. J Biol Chem 280, 32676-32682.
94. Neal, R.A. and Pearson, W.N. (1964) Studies of thiamine metabolism in the rat. I. Metabolic products found in urine. J Nutr 83, 343-350.
95. Nghiêm, H.O., Bettendorff, L., and Changeux, J.P. (2000) Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor. FASEB J 14, 543-554.
96. Nixon, P.F., Jordan, L., Zimitat, C., et al. (2008) Choroid plexus dysfunction: the initial event in the pathogenesis of Wernicke's encephalopathy and ethanol intoxication. Alcohol Clin Exp Res 32, 1513-1523.
97. Nozaki, S., Mizuma, H., Tanaka, M., et al. (2009) Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats. Nutr Res, 29, 867-872.
98. Oishi, K., Hirai, T., Gelb, B.D., et al. (2001) Slc19a2: cloning and characterization of the murine thiamin transporter cDNA and genomic sequence, the orthologue of the human TRMA gene. Mol Genet Metab 73, 149-159.
99. Oishi, K., Hofmann, S., Diaz, G.A., et al. (2002) Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Hum Mol Genet 11, 2951-2960.
100. Pan, X., Gong, N., Zhao, J., et al. (2010) Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 133, 1342-1351.
101. Pearson, W.N., Hung, E., Darby, W.J.J., et al. (1966) Excretion of metabolites of 14C-pyrimidine-labeled thimine by the rat at different levels of thiamine intake. J Nutr 89, 133-142.
102. Peterson, J.W., Gubler, C.J., and Kuby, S.A. (1975) Partial purification and properties of thiamine pyrophosphokinase from pig brain. Biochim Biophys Acta 397, 377-394.
103. Poggi, V., Longo, G., DeVizia, B., et al. (1984) Thiamin-responsive megaloblastic anaemia: a disorder of thiamin transport? J Inher Metab Dis 7 (Suppl 2), 153-154.
104. Rajgopal, A., Edmondson, A., Goldman, I.D., et al. (2001) SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta 1537, 175-178.
105. Reidling, J.C. and Said, H.M. (2005) Adaptive regulation of intestinal thiamin uptake: molecular mechanism using wild-type and transgenic mice carrying hTHTR-1 and-2 promoters. Am J Physiol Gastrointest Liver Physiol 288, G1127-1134.
106. Reidling, J.C., Lambrecht, N., Kassir, M., et al. (2010) Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Gastroenterology 138, 1802-1809.
107. Rindi, G. and Ferrari, G. (1977) Thiamine transport by human intestine in vitro. Experientia 33, 211-213.
108. Rindi, G., Casirola, D., Poggi, V., et al. (1992) Thiamine transport by erythrocytes and ghosts in thiamine-responsive megaloblastic anaemia. J Inherit Metab Dis 15, 231-242.
109. Rindi, G., Imarisio, L., and Patrini, C. (1986) Effects of acute and chronic ethanol administration on regional thiamin pyrophosphokinase activity of the rat brain. Biochem Pharmacol 35, 3903-3908.
110. Rindi, G., Patrini, C., Comincioli, V., et al. (1980) Thiamine content and turnover rates of some rat nervous regions, using labeled thiamine as a tracer. Brain Res 181, 369-380.
111. Rindi, G., Patrini, C., Laforenza, U., et al. (1994) Further studies on erythrocyte thiamin transport and phosphorylation in seven patients with thiamin-responsive megaloblastic anaemia. J Inherit Metab Dis 17, 667-677.
112. Romanenko, A.V. (1990) A new way of muscle activity regulation: thiamine participation in neuromuscular transmission. Muscle Motil 2, 151-153.
113. Roser, R.L., Andrist, A.H., Harrington, W.H., et al. (1978) Determination of urinary thiamine by high-pressure liquid chromatography utilizing the thiochrome fluorescent method. J Chromatogr 146, 43-53.
114. Said, H.M., Balamurugan, K., Subramanian, V.S., et al. (2004) Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine. Am J Physiol Gastrointest Liver Physiol 286, G491-498.
115. Said, H.M., Ortiz, A., Subramanian, V.S., et al. (2001c) Mechanism of thiamine uptake by human colonocytes: studies with cultured colonic epithelial cell line NCM460. Am J Physiol Gastrointest Liver Physiol 281, G144-150.
116. Said, H.M., Reidling, J.C., and Ortiz, A. (2002) Cellular and molecular aspects of thiamin uptake by human liver cells: studies with cultured HepG2 cells. Biochim Biophys Acta 1567, 106-112.
117. Sanemori, H. and Kawasaki, T. (1982) Thiamine triphosphate metabolism and its turnover in the rat liver. Experientia 38, 1044-1045.
118. Sanemori, H., Ueki, H., and Kawasaki, T. (1980) Reversed-phase high-performance liquid chromatographic analysis of thiamine phosphate esters at subpicomole levels. Anal Biochem 107, 451-455.
119. Shikata, H., Egi, Y., Koyama, S., et al. (1989a) Properties of the thiamin triphosphate-synthesizing activity catalyzed by adenylate kinase (isoenzyme 1). Biochem Int 18, 943-949.
120. Shikata, H., Koyama, S., Egi, Y., et al. (1989b) Cytosolic adenylate kinase catalyzes the synthesis of thiamin triphosphate from thiamin diphosphate. Biochem Int 18, 933-941.
121. Shimomura, T., Mori, E., Hirono, N., et al. (1998) Development of Wernicke-Korsakoff syndrome after long intervals following gastrectomy. Arch Neurol 55, 1242-1245.
122. Sica, D.A. (2007) Loop diuretic therapy, thiamine balance, and heart failure. Congestive Heart Failure 13, 244-247.
123. Singh, M., Thompson, M., Sullivan, N., et al. (2005) Thiamine deficiency in dogs due to the feeding of sulphite preserved meat. Aust Vet J 83, 412-417.
124. Smidt, L.J., Cremin, F.M., Grivetti, L.E., et al. (1991c) Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin defi-ciency. J Gerontol 46, M16-22.
125. Song, J., Bettendorff, L., Tonelli, M., et al. (2008) Structural basis for the catalytic mechanism of mammalian 25-kDa thiamine triphosphatase. J Biol Chem 283, 10939-10948.
126. Spector, R. and Johanson, C.E. (2007) Vitamin transport and homeostasis in mammalian brain: focus on vitamins B and E. J Neurochem 103, 425-438.
127. Stagg, A.R., Fleming, J.C., Baker, M.A., et al. (1999) Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. J Clin Invest 103, 723-729.
128. Subramanian, V.S., Marchant, J.S., and Said, H.M. (2006c) Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via the human thiamine transporter-2 (hTHTR2): biotin is not a substrate for hTHTR2. Am J Physiol Cell Physiol 291, C851-C859.
129. Subramanya, S.B., Subramanian, V.S., and Said, H.M. (2010c) Chronic alcohol consumption and intestinal thiamin absorption: effects on physiological and molecular parameters of the uptake process. Am J Physiol Gastrointest Liver Physiol 299, G23-31.
130. Takaki, K. (1885) On the cause and prevention of Kak'ke. Sei-i-kai Medical J 4 (Suppl 4), 29-37.
131. Thurman, J.E. and Mooradian, A.D. (1997) Vitamin supplementation therapy in the elderly. Drugs Aging 11, 433-449.
132. van Zaanen, H.C. and van der Lelie, J. (1992) Thiamine deficiency in hematologic malignant tumors. Cancer 69, 1710-1713.
133. Victor, M., Adams, R.D., and Collins, G.H. (1989) The Wernicke-Korsakoff Syndrome and Related Neurological Disorders due to Alcoholism and Malnutrition. F.A. Davies, Philadelphia.
134. Vlasova, T.I., Stratton, S.L., Wells, A.M., et al. (2005) Biotin defi-ciency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood. J Nutr 135, 42-47.
135. Vognar, L. and Stoukides, J. (2009) The role of low plasma thiamin levels in cognitively impaired elderly patients presenting with acute behavioral disturbances. J Am Geriatr Soc 57, 2166-2168.
136. Volvert, M.L., Seyen, S., Piette, M., et al. (2008) Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacol 8, 10.
137. Wang, Y., Zhao, R., Russell, R.G., et al. (2001) Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochim Biophys Acta 1513, 49-54.
138. Wilkinson, T.J., Hanger, H.C., Elmslie, J., et al. (1997) The response to treatment of subclinical thiamine deficiency in the elderly. Am J Clin Nutr 66, 925-928.
139. Williams, R.R. and Cline, J.K. (1936) Synthesis of vitamin B1. J Am Chem Soc 58, 1504-1505.
140. Xu, X., Zur Hausen, A., Coy, J.F., et al. (2009) Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer 124, 1330-1337.
141. Yoshioka, K. (1984) Some properties of the thiamine uptake system in isolated rat hepatocytes. Biochim Biophys Acta 778, 201-209.
142. Zeng, W.Q., Al-Yamani, E., Acierno, J.S., Jr, et al. (2005) Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3. Am J Human Genet 77, 16-26.
143. Zhao, R., Gao, F., and Goldman, I.D. (2002c) Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Am J Physiol Cell Physiol 282, C1512-C1517.
144. Zhao, R., Gao, F., Wang, Y., et al. (2001) Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells. J Biol Chem 276, 1114-1118.