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Volumn 2, Issue 1, 2013, Pages 53-58

Pros and cons of pragmatic clinical trials

Author keywords

comparative effectiveness; explanatory trial; mechanistic trial; practical trial; pragmatic clinical trial; randomized control trial; trial design

Indexed keywords

ANALYTICAL ERROR; CLINICAL RESEARCH; CLINICAL STUDY; CLINICAL TRIAL (TOPIC); DATA ANALYSIS; INFORMATION PROCESSING; MEDICAL DECISION MAKING; PATIENT SELECTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SAMPLE SIZE; STUDY DESIGN;

EID: 84886945315     PISSN: 20426305     EISSN: 20426313     Source Type: Journal    
DOI: 10.2217/cer.12.74     Document Type: Review
Times cited : (40)

References (21)
  • 1
  • 2
    • 11444261579 scopus 로고    scopus 로고
    • External validity of randomised controlled trials: "to whom do the results of this trial apply?"
    • DOI 10.1016/S0140-6736(04)17670-8, PII S0140673604176708
    • Rothwell PM. External validity of randomised controlled trials: 'to whom do the results of this trial apply?'. Lancet 365(9453), 82-93 (2005). (Pubitemid 40082150)
    • (2005) Lancet , vol.365 , Issue.9453 , pp. 82-93
    • Rothwell, P.M.1
  • 3
    • 0014115513 scopus 로고
    • Explanatory and pragmatic attitudes in therapeutical trials
    • Schwartz D, Lellouch J. Explanatory and pragmatic attitudes in therapeutical trials. J. Chronic Dis. 20(8), 637-648 (1967).
    • (1967) J. Chronic Dis , vol.20 , Issue.8 , pp. 637-648
    • Schwartz, D.1    Lellouch, J.2
  • 4
    • 63649136121 scopus 로고    scopus 로고
    • Explanatory and pragmatic attitudes in therapeutical trials
    • Schwartz D, Lellouch J. Explanatory and pragmatic attitudes in therapeutical trials. J. Clin. Epidemiol. 62(5), 499-505 (2009).
    • (2009) J. Clin. Epidemiol , vol.62 , Issue.5 , pp. 499-505
    • Schwartz, D.1    Lellouch, J.2
  • 5
    • 80052146670 scopus 로고    scopus 로고
    • A pragmatic view on pragmatic trials
    • Patsopoulos NA. A pragmatic view on pragmatic trials. Dialogues Clin. Neurosci. 13(2), 217-224 (2011).
    • (2011) Dialogues Clin. Neurosci , vol.13 , Issue.2 , pp. 217-224
    • Patsopoulos, N.A.1
  • 6
    • 80052383955 scopus 로고    scopus 로고
    • Explanatory and pragmatic clinical trials: A primer and application to a recent asthma trial
    • Sackett DL. Explanatory and pragmatic clinical trials: a primer and application to a recent asthma trial. Pol. Arch. Med. Wewn. 121(7-8), 259-263 (2011).
    • (2011) Pol. Arch. Med. Wewn , vol.121 , Issue.7-8 , pp. 259-263
    • Sackett, D.L.1
  • 7
    • 3042677714 scopus 로고    scopus 로고
    • Pragmatic controlled clinical trials in primary care: The struggle between external and internal validity
    • Godwin M, Ruhland L, Casson I et al. Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity. BMC Med. Res. Methodol. 3, 28 (2003).
    • (2003) BMC Med. Res. Methodol , vol.3 , pp. 28
    • Godwin, M.1    Ruhland, L.2    Casson, I.3
  • 8
    • 63449090101 scopus 로고    scopus 로고
    • A pragmatic-explanatory continuum indicator summary (PRECIS): A tool to help trial designers
    • Thorpe KE, Zwarenstein M, Oxman AD et al. A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. J. Clin. Epidemiol. 62(5), 464-475 (2009).
    • (2009) J. Clin. Epidemiol , vol.62 , Issue.5 , pp. 464-475
    • Thorpe, K.E.1    Zwarenstein, M.2    Oxman, A.D.3
  • 10
    • 77957680269 scopus 로고    scopus 로고
    • Myth and reality of pragmatic trials
    • Mohr P, Bitter I, Constant E et al. Myth and reality of pragmatic trials. Psychiatr. Danub. 22(1), 2-3 (2010).
    • (2010) Psychiatr. Danub , vol.22 , Issue.1 , pp. 2-3
    • Mohr, P.1    Bitter, I.2    Constant, E.3
  • 11
    • 68349096138 scopus 로고    scopus 로고
    • Against pragmatism: On efficacy, effectiveness and the real world
    • Kent DM, Kitsios G. Against pragmatism: on efficacy, effectiveness and the real world. Trials 10, 40 (2009).
    • (2009) Trials , vol.10 , pp. 40
    • Kent, D.M.1    Kitsios, G.2
  • 12
    • 77956950318 scopus 로고    scopus 로고
    • The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) instrument was useful for refining a randomized trial design: Experiences from an investigative team
    • Riddle DL, Johnson RE, Jensen MP et al. The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) instrument was useful for refining a randomized trial design: experiences from an investigative team. J. Clin. Epidemiol. 63(11), 1271-1275 (2010).
    • (2010) J. Clin. Epidemiol , vol.63 , Issue.11 , pp. 1271-1275
    • Riddle, D.L.1    Johnson, R.E.2    Jensen, M.P.3
  • 13
    • 0014115513 scopus 로고
    • Explanatory and pragmatic attitudes in therapeutical trials
    • Schwartz D, Lellouch J. Explanatory and pragmatic attitudes in therapeutical trials. J. Chronic Dis. 20(8), 637-648 (1967).
    • (1967) J. Chronic Dis , vol.20 , Issue.8 , pp. 637-648
    • Schwartz, D.1    Lellouch, J.2
  • 14
    • 67649661825 scopus 로고    scopus 로고
    • Making trials matter: Pragmatic and explanatory trials and the problem of applicability
    • Treweek S, Zwarenstein M. Making trials matter: pragmatic and explanatory trials and the problem of applicability. Trials 10, 37 (2009).
    • (2009) Trials , vol.10 , pp. 37
    • Treweek, S.1    Zwarenstein, M.2
  • 15
    • 78149470444 scopus 로고    scopus 로고
    • What have we learned about trial design from NIMH-funded pragmatic trials?
    • March J, Kraemer HC, Trivedi M et al. What have we learned about trial design from NIMH-funded pragmatic trials? Neuropsychopharmacology 35(13), 2491-2501 (2010).
    • (2010) Neuropsychopharmacology , vol.35 , Issue.13 , pp. 2491-2501
    • March, J.1    Kraemer, H.C.2    Trivedi, M.3
  • 16
    • 0028849245 scopus 로고
    • Subverting randomization in controlled trials
    • Schulz KF. Subverting randomization in controlled trials. JAMA 274(18), 1456-1458 (1995).
    • (1995) JAMA , vol.274 , Issue.18 , pp. 1456-1458
    • Schulz, K.F.1
  • 17
    • 0025734372 scopus 로고
    • Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis
    • North American Symptomatic Carotid Endarterectomy Trial Collaborators
    • North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N. Engl. J. Med. 325(7), 445-453 (1991).
    • (1991) N. Engl. J. Med , vol.325 , Issue.7 , pp. 445-453
  • 18
    • 0032557175 scopus 로고    scopus 로고
    • Variation in carotid endarterectomy mortality in the medicare population: Trial hospitals, volume, and patient characteristics
    • DOI 10.1001/jama.279.16.1278
    • Wennberg DE, Lucas FL, Birkmeyer JD, Bredenberg CE, Fisher ES. Variation in carotid endarterectomy mortality in the Medicare population: trial hospitals, volume, and patient characteristics. JAMA 279(16), 1278-1281 (1998). (Pubitemid 28180780)
    • (1998) Journal of the American Medical Association , vol.279 , Issue.16 , pp. 1278-1281
    • Wennberg, D.E.1    Lucas, F.L.2    Birkmeyer, J.D.3    Bredenberg, C.E.4    Fisher, E.S.5
  • 19
    • 0141684982 scopus 로고    scopus 로고
    • Practical Clinical Trials: Increasing the Value of Clinical Research for Decision Making in Clinical and Health Policy
    • DOI 10.1001/jama.290.12.1624
    • Tunis SR, Stryer DB, Clancy CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA 290(12), 1624-1632 (2003). (Pubitemid 37430387)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.12 , pp. 1624-1632
    • Tunis, S.R.1    Stryer, D.B.2    Clancy, C.M.3
  • 20
    • 0028831227 scopus 로고
    • Large-scale randomized evidence: Large, simple trials and overviews of trials
    • Peto R, Collins R, Gray R. Large-scale randomized evidence: large, simple trials and overviews of trials. J. Clin. Epidemiol. 48(1), 23-40 (1995).
    • (1995) J. Clin. Epidemiol , vol.48 , Issue.1 , pp. 23-40
    • Peto, R.1    Collins, R.2    Gray, R.3
  • 21
    • 57349108691 scopus 로고    scopus 로고
    • Improving the reporting of pragmatic trials: An extension of the CONSORT statement
    • Zwarenstein M, Treweek S, Gagnier JJ et al. Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ 337, a2390 (2008).
    • (2008) BMJ , vol.337
    • Zwarenstein, M.1    Treweek, S.2    Gagnier, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.