DEC-205 is a cell surface receptor for CpG oligonucleotides

OncoImmunology

Volumn 2, Issue 3, 2013, Pages

  Caminschi, Irina ^a,b,c   Meuter, Simone ^b,c   Heath, William R ^c  

^a BURNET INSTITUTE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Adjuvants; CpG; Dendritic cells; TLR9; Vaccines

Indexed keywords

CELL PROTEIN; CPG OLIGODEOXYNUCLEOTIDE; CPG OLIGODEOXYNUCLEOTIDE 2006; DEC 205 PROTEIN; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CLEC12A; MONOCYTE CHEMOTACTIC PROTEIN 1; OVALBUMIN; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; INNATE IMMUNITY; INTERNALIZATION; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MOTIF; T LYMPHOCYTE ACTIVATION; UPREGULATION;

EID: 84886945194     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.23128     Document Type: Article

References (10)

1. Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol 2011; 30:16-34; PMID:21235323; http://dx.doi.org/10.3109/08830185.2010.529976.
2. Wagner H. The sweetness of the DNA backbone drives Toll-like receptor 9. Curr Opin Immunol 2008; 20:396-400; PMID:18656540; http://dx.doi. org/10.1016/j.coi.2008.06.013.
3. Bode C, Zhao G, Steinhagen F, Kinjo T, Klinman DM. CpG DNA as a vaccine adjuvant. Expert Rev Vaccines 2011; 10:499-511; PMID:21506647; http://dx.doi.org/10.1586/erv.10.174.
4. Sester DP, Naik S, Beasley SJ, Hume DA, Stacey KJ. Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J Immunol 2000; 165:4165-73; PMID:11035048.
5. Roberts TL, Dunn JA, Sweet MJ, Hume DA, Stacey KJ. The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes. Mol Immunol 2011; 48:1027-34; PMID:21324527; http://dx.doi.org/10.1016/j.molimm.2011.01.011.
6. Lahoud MH, Ahmet F, Zhang JG, Meuter S, Policheni AN, Kitsoulis S, et al. DEC-205 is a cell surface receptor for CpG oligonucleotides. Proc Natl Acad Sci U S A 2012; 109:16270-5; PMID:22988114; http://dx.doi.org/10.1073/pnas.1208796109.
7. Haas T, Metzger J, Schmitz F, Heit A, Müller T, Latz E, et al. The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. Immunity 2008; 28:315-23; PMID:18342006; http://dx.doi.org/10.1016/j.immuni.2008.01.013.
8. Lahoud MH, Ahmet F, Kitsoulis S, Wan SS, Vremec D, Lee CN, et al. Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype. J Immunol 2011; 187:842-50; PMID:21677141; http://dx.doi.org/10.4049/jimmunol.1101176.
9. Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdörfer B, Giese T, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002; 168:4531-7; PMID:11970999.
10. Kato M, McDonald KJ, Khan S, Ross IL, Vuckovic S, Chen K, et al. Expression of human DEC-205 (CD205) multilectin receptor on leukocytes. Int Immunol 2006; 18:857-69; PMID:16581822; http://dx.doi.org/10.1093/intimm/dxl022.