Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

OncoImmunology

Volumn 2, Issue 3, 2013, Pages

  Lim, Su Yin ^a   Gordon Weeks, Alex N ^a   Zhao, Lei ^a   Tapmeier, Thomas T ^a   Im, Jae Hong ^a   Cao, Yunhong ^a   Beech, John ^a   Allen, Danny ^a   Smart, Sean ^a   Muschel, Ruth J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CCL2; Colon cancer; Liver metastasis; Myeloid cell recruitment

Indexed keywords

CD11B ANTIGEN; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; SECONDARY LYMPHOID TISSUE CHEMOKINE;

ARTICLE; BIOACCUMULATION; BONE MARROW CELL; CANCER GROWTH; CELL EXPANSION; CELL FUNCTION; CELL INFILTRATION; CELL POPULATION; CELL SPECIFICITY; HUMAN; LIVER METASTASIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR MICROENVIRONMENT; TUMOR VOLUME;

EID: 84886944431     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.23187     Document Type: Article

References (8)

1. Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 2008; 13:23-35; PMID: 18167337; DOI: 10.1016/j.ccr.2007.12.004.
2. Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011; 475:222-5; PMID: 21654748; DOI: 10.1038/nature10138.
3. Kowanetz M, Wu X, Lee J, Tan M, Hagenbeek T, Qu X, et al. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A 2010; 107:21248-55; PMID: 21081700; DOI: 10.1073/pnas.1015855107.
4. Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, et al. Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A 2010; 107:13063-8; PMID: 20616008; DOI: 10.1073/pnas.1002372107.
5. Zhao L, Lim SY, Gordon-Weeks AN, Tapmeier TT, Im JH, Cao Y, et al. Recruitment of a myeloid cell subset (CD11b/Gr1(mid))via CCL2/CCR2 promotes thedevelopment of colorectal cancer liver metastasis. Hepatology 2012;; PMID: 23081697; DOI: 10.1002/hep.26094.
6. Yoshidome H, Kohno H, Shida T, Kimura F, Shimizu H, Ohtsuka M, et al. Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases. Int J Oncol 2009; 34:923-30; PMID: 19287949; DOI: 10.3892/ijo_00000218.
7. Hu H, Sun L, Guo C, Liu Q, Zhou Z, Peng L, et al. Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clin Cancer Res 2009; 15:5485-93; PMID: 19706805; DOI: 10.1158/1078-0432.CCR-08-2491.
8. Balkwill FR, Mantovani A. Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol 2012; 22:33-40; PMID: 22210179; DOI: 10.1016/j.semcancer.2011.12.005.