The canonical WNT2 pathway and FSH interact to regulate gap junction assembly in mouse granulosa cells

Biology of Reproduction

Volumn 89, Issue 2, 2013, Pages

  Wang, Hong Xing ^a,c   Gillio Meina, Carolina ^a,b   Chen, Shuli ^a,d   Gong, Xiang Qun ^a   Li, Tony Y ^a,e   Bai, Donglin ^a   Kidder, Gerald M ^a,b  

^a WESTERN UNIVERSITY   (Canada)

^b CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^e Bellamy Ellesmere Medical Centre   (Canada)

Author keywords

Adherens junction; Beta catenin; Connexin43; Gap junction; Ovarian folliculogenesis

Indexed keywords

BETA CATENIN; CONNEXIN 43; FOLLITROPIN; SMALL INTERFERING RNA; WNT2 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMMUNICATION; CELL JUNCTION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GAP JUNCTION; GENE EXPRESSION REGULATION; GENE SILENCING; GRANULOSA CELL; MOUSE; NONHUMAN; OVARY FOLLICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; WNT SIGNALING PATHWAY; ADHERENS JUNCTION; ANIMAL; BETA-CATENIN; CELL CULTURE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONNEXIN43; CYTOLOGY; DRUG EFFECT; METABOLISM; OVARIAN FOLLICULOGENESIS; PHYSIOLOGY;

ADHERENS JUNCTION; BETA-CATENIN; CONNEXIN43; GAP JUNCTION; OVARIAN FOLLICULOGENESIS;

ADHERENS JUNCTIONS; ANIMALS; BETA CATENIN; CELL COMMUNICATION; CELL PROLIFERATION; CELLS, CULTURED; CONNEXIN 43; FEMALE; FOLLICLE STIMULATING HORMONE; GAP JUNCTIONS; GRANULOSA CELLS; MICE; S PHASE; WNT SIGNALING PATHWAY; WNT2 PROTEIN;

EID: 84886918478     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.113.109801     Document Type: Article

References (30)

1. Boyer A, Goff AK, Boerboom D. WNT signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol Metab 2009; 21:25-32.
2. Lapointe E, Boerboom D. WNT signaling and the regulation of ovarian steroidogenesis. Front Biosci 2011; 3:276-285.
3. Hernández AR, Klein AM, Kirschner MW. Kinetic responses of b-catenin specify the sites of Wnt control. Science 2012; 338:1337-1340.
4. Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiplereceptors, and multiple transcription factors. J Biol Chem 2006; 281: 22429-22433.
5. Wang HX, Li TY, Kidder GM. WNT2 regulates DNA synthesis in mouse granulosa cells through beta-catenin. Biol Reprod 2010; 82:865-875.
6. Harris AL. Connexin channel permeability to cytoplasmic molecules. Prog Biophys Mol Biol 2007; 94:120-143.
7. Wei CJ, Xu X, Lo CW. Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol 2004; 20:811-838.
8. Kidder GM, Vanderhyden BC. Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence. Can J Physiol Pharmacol 2010; 88:399-413.
9. Ackert CL, Gittens JEI, O'Brien MJ, Eppig JJ, Kidder GM. Intercellular communication via connexin43 gap junctions is required for ovarian folliculogenesis in the mouse. Dev Biol 2001; 233:258-270.
10. Tong D, Gittens JEI, Kidder GM, Bai D. Patch clamp study reveals that the importance of connexin43-mediated gap junctional communication for ovarian folliculogenesis is strain-specific in the mouse. Am J Physiol Cell Physiol 2006; 290:C290-C297.
11. van der Heyden MA, Rook MB, Hermans MM, Rijksen G, Boonstra J, Defize LH, Destrée OH. Identification of connexin43 as a functional target for Wnt signalling. J Cell Sci 1998; 111:1741-1749.
12. Ai Z, Fischer A, Spray DC, Brown AM, Fishman GI. Wnt-1 regulation of connexin43 in cardiac myocytes. J Clin Invest 2000; 105:161-171.
13. Xia X, Batra N, Shi Q, Bonewald LF, Sprague E, Jiang JX. Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin43 by glycogen synthase kinase 3/beta-catenin signaling. Mol Cell Biol 2010; 30:206-219.
14. Granot I, Dekel N. The ovarian gap junction protein connexin43: regulation by gonadotropins. Trends Endocrinol Metab 2002; 13:310-313.
15. Rudloff S, Kemler R. Differential requirements for b-catenin during mouse development. Development 2012; 139:3711-3721.
16. Parakh TN, Hernandez JA, Grammer JC, Weck J, Hunzicker-Dunn M, Zeleznik AJ, Nilson JH. Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires b-catenin. Proc Natl Acad Sci USA 2006; 103:12435-12440.
17. Fan HY, O'Connor A, Shitanaka M, Shimada M, Liu Z, Richards JS. Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization. Mol Endocrinol 2010; 24:1529-1542.
18. Burghardt RC , Matheson RL. Gap junction amplification in rat ovarian granulosa cells. Dev Biol 1982; 94:206-215.
19. Yun SP, Ryu JM, Park JH, Kim MO, Lee JH, Han HJ. Prostaglandin E2 maintains mouse ESC undifferentiated state through regulation of connexin31, connexin43 and connexin45 expression: involvement of glycogen synthase kinase 3b/b-catenin. Biol Cell 2012; 104:378-96.
20. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell 2007; 128:547-560.
21. Ale-Agha N , Galban S, Sobieroy C, Abdelmohsen K, Gorospe M, Sies H, Klotz LO. HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity. Hepatology 2009; 50:1567-1576.
22. Laird DW. Th e gap junction proteome and its relationship to disease. Trends Cell Biol 2009; 20:92-101.
23. 2+ in mouse epidermal cells is controlled by E-cadherin. J Cell Biol 1991; 114:545-555.
24. Wei CJ, Francis R, Xu X, Lo CW. Connexin43 associated with an Ncadherin- containing multiprotein complex is required for gap junction formation in NIH3T3 cells. J Biol Chem 2005; 280:19925-19936.
25. Luo Y, Radice GL. Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus. J Cell Sci 2003; 116:1471-1479.
26. Li J, Patel VV, Kostetskii I, Xiong Y, Chu AF, Jacobson JT, Yu C, Morley GE, Molkentin JD, Radice GL. Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res 2005; 97:474-81.
27. Gittens J EI, Barr KJ, Vanderhyden BC, Kidder GM. Interplay between paracrine signaling and gap junctional communication in ovarian follicles. J Cell Sci 2005; 118:113-122.
28. Hino S, Tanji C, Nakayama KI, Kikuchi A. Phosphorylation of b-catenin by cyclic AMP-dependent protein kinase stabilizes b-catenin through inhibition of its ubiquitination. Mol Cell Biol 2005; 25:9063-9072.
29. Taurin S, Sandbo N, Qin Y, Browning D, Dulin NO. Phosphorylation of b-catenin by cyclic AMP-dependent protein kinase. J Biol Chem 2006; 281:9971-9976.
30. Taurin S, Sandbo N, Yau DM, Sethakorn N, Dulin NO. Phosphorylation of β-catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells. Am J Physiol Cell Physiol 2008; 294:C1169-1174.