Production and First-in-Man Use of T Cells Engineered to Express a HSVTK-CD34 Sort-Suicide Gene

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Zhan, Hong ^a   Gilmour, Kimberly ^a   Chan, Lucas ^b   Farzaneh, Farzin ^b   McNicol, Anne Marie ^a   Xu, Jin Hua ^a   Adams, Stuart ^a   Fehse, Boris ^c   Veys, Paul ^a   Thrasher, Adrian ^a   Gaspar, Hubert ^a   Qasim, Waseem ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; CD34 ANTIGEN; CYCLOSPORIN; HERPES SIMPLEX THYMIDINE KINASE; MONOCLONAL ANTIBODY CD28; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RETROVIRUS VECTOR; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ACUTE GRAFT VERSUS HOST DISEASE; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CASE REPORT; CELL ENGINEERING; CELL THERAPY; CHILD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA MODIFICATION; DRUG SYNTHESIS; DRUG TOLERABILITY; GENE EXPRESSION SYSTEM; GIBBON LEUKEMIA VIRUS; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; PATIENT SAFETY; SUICIDE GENE; SUICIDE GENE THERAPY; T CELL DEPLETION; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM;

ANTIGENS, CD34; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; GANCICLOVIR; GENES, TRANSGENIC, SUICIDE; GENETIC THERAPY; GENETIC VECTORS; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; INFANT, NEWBORN; LEUKEMIA VIRUS, GIBBON APE; LYMPHOCYTE ACTIVATION; MALE; SIMPLEXVIRUS; T-LYMPHOCYTES; THYMIDINE KINASE; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 84886913160     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077106     Document Type: Article

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