Seven challenges for neuroscience

Functional Neurology

Volumn 28, Issue 3, 2013, Pages 145-151

  Markram, Henry ^a  

^a EPFL   (Switzerland)

Author keywords

Big science; Brain disease; Brain simulation; Data ladders; Predictive neuroscience; Social concern

Indexed keywords

ARTICLE; BRAIN DEPTH STIMULATION; BRAIN DISEASE; COMPUTER PROGRAM; ELECTROENCEPHALOGRAM; ELECTROPHYSIOLOGY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ENGINEERING AND GENE TECHNOLOGY; HUMAN; INTERNEURON; NEUROMODULATION; NEUROSCIENCE; NONHUMAN; RESEARCH; SCIENTIST;

EID: 84886905482     PISSN: 03935264     EISSN: 19713274     Source Type: Journal    
DOI: 10.11138/FNeur/2013.28.3.145     Document Type: Article

References (11)

1. Abbott A (2011). Novartis to shut brain research facility. Nature 480:161-162.
2. Ascoli GA, Alonso-Nanclares L, Anderson SA, et al (2008). Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci 9: 557-568.
3. Beach TG, Monsell SE, Phillips LE, et al. (2012) Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010. J Neuropathol Exp Neurol. 71:266-273.
4. Cuntz H, Forstner F, Borst A, et al (2010). One rule to grow them all: a general theory of neuronal branching and its practical application. PLoS Comput Biol 6: e1000877.
5. Hay E, Hill S, Schürmann F, et al (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS Comput Biol 7: e1002107.
6. Hill SL, Wang Y, Riachi I, et al (2012). Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits. Proc Natl Acad Sci U S A 109: E2885-E2894.
7. Khazen G, Hill SL, Schürmann F, et al (2012). Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons. PLoS One 7: e34786.
8. Pangalos MN, Schechter LE, Hurko O (2007). Drug development for CNS disorders: strategies for balancing risk and reducing attrition. Nat Rev Drug Discov 6: 521-532.
9. Perin R, Berger TK, Markram H (2011). A synaptic organizing principle for cortical neuronal groups. Proc Natl Acad Sci U S A 108: 5419-5424.
10. Song S, Sjöström PJ, Reigl M, et al (2005). Highly nonrandom features of synaptic connectivity in local cortical circuits. PLoS Biol 3: e68.
11. Gustavsson A, Svensson M, Jacobi F, et al. (2011) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21: 718-779.