The Effect of Different Adjuvants on Immune Parameters and Protection following Vaccination of Sheep with a Larval-Specific Antigen of the Gastrointestinal Nematode, Haemonchus contortus

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Piedrafita, David ^a   Preston, Sarah ^a   Kemp, Joanna ^a   de Veer, Michael ^a   Sherrard, Jayne ^a   Kraska, Troy ^a   Elhay, Martin ^b   Meeusen, Els ^a  

^a MONASH UNIVERSITY   (Australia)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIETHYLAMINOETHANOL; ALUMINUM PHOSPHATE; ANTIGEN; DEXTRAN; IMMUNOLOGICAL ADJUVANT; LARVAL SPECIFIC HAEMONCHUS CONTORTUS ANTIGEN; UNCLASSIFIED DRUG; DIETHYLAMINOETHYLDEXTRAN; HELMINTH ANTIBODY; PARASITE ANTIGEN; PHARMACEUTICAL VEHICLES AND ADDITIVES; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; EOSINOPHIL; FECES ANALYSIS; HAEMONCHOSIS; HAEMONCHUS CONTORTUS; HEMATOLOGY; IMMUNOLOGICAL PARAMETERS; LARVA; NONHUMAN; PARASITOLOGY; PROTECTION; SEROLOGY; SHEEP; VACCINATION; ANIMAL; DIET THERAPY; DRUG EFFECTS; FECES; GASTROINTESTINAL DISEASES; HAEMONCHUS; IMMUNOLOGY; NEMATODE; NEMATODE INFECTIONS; PARASITE IDENTIFICATION; PROCEDURES; SHEEP DISEASES;

ADJUVANTS, IMMUNOLOGIC; ADJUVANTS, PHARMACEUTIC; ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; DEAE-DEXTRAN; FECES; GASTROINTESTINAL DISEASES; HAEMONCHIASIS; HAEMONCHUS; LARVA; NEMATODA; NEMATODE INFECTIONS; PARASITE EGG COUNT; SHEEP; SHEEP DISEASES; VACCINATION; VACCINES;

EID: 84886882693     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078357     Document Type: Article

References (25)

1. Anthony RM, Rutitzky LI, Urban JF Jr, Stadecker MJ, Gause WC, (2007) Protective immune mechanisms in helminth infection. Nat Rev Immunol 7: 975-987.
2. Hein WR, Pernthaner A, Piedrafita D, Meeusen EN, (2010) Immune mechanisms of resistance to gastrointestinal nematode infections in sheep. Parasite Immunol 32: 541-548.
3. Meeusen EN, Balic A, Bowles V, (2005) Cells, cytokines and other molecules associated with rejection of gastrointestinal nematode parasites. Vet Immunol Immunopathol 108: 121-125.
4. Zinkernagel RM, Hengartner H, (2006) Protective 'immunity' by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called 'immunological memory'. Immunol Rev 211: 310-319.
5. Bethony JM, Loukas A, Hotez PJ, Knox DP, (2006) Vaccines against blood-feeding nematodes of humans and livestock. Parasitology 133Suppl: S63-79.
6. de Veer M, Meeusen E, (2011) New developments in vaccine research-unveiling the secret of vaccine adjuvants. Discov Med 12: 195-204.
7. Pulendran B, Ahmed R, (2011) Immunological mechanisms of vaccination. Nat Immunol 12: 509-517.
8. Jacobs HJ, Wiltshire C, Ashman K, Meeusen ENT, (1999) Vaccination against the gastrointestinal nematode, Haemonchus contortus, using a purified larval surface antigen. Vaccine 17: 362-368.
9. Piedrafita D, de Veer MJ, Sherrard J, Kraska T, Elhay M, et al. (2012) Field vaccination of sheep with a larval-specific antigen of the gastrointestinal nematode, Haemonchus contortus. Vaccine 30: 7199-71204.
10. Thakur A, Pedersen LE, Jungersen G, (2012) Immune markers and correlates of protection for vaccine induced immune responses. Vaccine 30: 4907-4920.
11. Beh KJ, (1987) Production and characterization of monoclonal antibodies specific for sheep IgG subclasses IgG1 or IgG2. Vet Immunol Immunopathol 14: 187-196.
12. Bischof RJ, Snibson K, Shaw R, Meeusen EN, (2003) Induction of allergic inflammation in the lungs of sensitized sheep after local challenge with house dust mite. Clin Exp Allergy 33: 367-375.
13. Duthie MS, Windish HP, Fox CB, Reed SG, (2011) Use of defined TLR ligands as adjuvants within human vaccines. Immunol Rev 239: 178-196.
14. Marrack P, McKee AS, Munks MW, (2009) Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol 9: 287-293.
15. Alving CR, (2002) Design and selection of vaccine adjuvants: animal models and human trials. Vaccine 20Suppl 3: S56-64.
16. Jankovic D, Kullberg MC, Caspar P, Sher A, (2004) Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling. J Immunol 173: 2419-2427.
17. Korsholm KS, Petersen RV, Agger EM, Andersen P, (2010) T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection. Immunology 129: 75-86.
18. Flach TL, Ng G, Hari A, Desrosiers MD, Zhang P, et al. (2011) Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat Med 17: 479-487.
19. de Veer M, Kemp J, Chatelier J, Elhay MJ, Meeusen EN, (2010) The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant. Vaccine 28: 6597-6602.
20. Meeusen EN, Balic A, (2000) Do eosinophils have a role in the killing of helminth parasites? Parasitol Today 16: 95-101.
21. Rainbird MA, Macmillan D, Meeusen ENT, (1998) Eosinophil-mediated killing of Haemonchus contortus larvae: Effect of eosinophil activation and role of antibody, complement and interleukin-5. Parasite Immunology 20: 93-103.
22. Balic A, Cunningham CP, Meeusen EN, (2006) Eosinophil interactions with Haemonchus contortus larvae in the ovine gastrointestinal tract. Parasite Immunol 28: 107-115.
23. Sun HX, Xie Y, Ye YP, (2009) Advances in saponin-based adjuvants. Vaccine 27: 1787-1796.
24. Turnbull IF, Bowles VM, Wiltshire CJ, Brandon MR, Meeusen EN, (1992) Systemic immunization of sheep with surface antigens from Haemonchus contortus larvae. Int J Parasitol 22: 537-540.
25. Vizcarra JA, Karges SL, Wettemann RP, (2012) Immunization of beef heifers against gonadotropin-releasing hormone prevents luteal activity and pregnancy: Effect of conjugation to different proteins and effectiveness of adjuvants. J Anim Sci 90: 1479-1488.