Hyperacute drug-induced hepatitis with intravenous amiodarone: Case report and review of the literature

Drug, Healthcare and Patient Safety

Volumn 5, Issue 1, 2013, Pages 191-198

  Nasser, Mohammad ^a   Larsen, Timothy R ^a   Waanbah, Barryton ^a   Sidiqi, Ibrahim ^a   McCullough, Peter A ^a  

^a PROVIDENCE HOSPITAL   (United States)

Author keywords

Acute hepatotoxicity; Drug induced liver Toxicity; Intravenous amiodarone; Liver transaminases

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMIODARONE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARVEDILOL; CREATININE; DILTIAZEM; LEVOTHYROXINE; LISINOPRIL; WARFARIN;

ACUTE HEART FAILURE; ACUTE HEPATITIS; AGED; ARTICLE; ARTIFICIAL HEART PACEMAKER; CARDIOVASCULAR RESPONSE; CASE REPORT; CORONARY ARTERY DISEASE; DEATH; DRUG WITHDRAWAL; DYSPNEA; ECHOCARDIOGRAPHY; ECHOGRAPHY; EDEMA; ELECTROCARDIOGRAM; EMOTIONAL STRESS; EOSINOPHILIA; FAMILY STRESS; FATIGUE; FEMALE; HEART ATRIUM FIBRILLATION; HEART CATHETERIZATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MURMUR; HEART PALPITATION; HEPATOGRAPHY; HUMAN; IMPLANTED HEART PACEMAKER; KIDNEY FAILURE; LABORATORY TEST; LEG EDEMA; LIVER CONGESTION; LOADING DRUG DOSE; PHYSICAL EXAMINATION; PRURITUS; RASH; RESPIRATORY FAILURE; SINUS RHYTHM; TOXIC HEPATITIS; VENOUS CONGESTION;

EID: 84886852658     PISSN: None     EISSN: 11791365     Source Type: Journal    
DOI: 10.2147/DHPS.S48640     Document Type: Article

References (34)

1. Smith TW, Cain ME. Class III antiarrhythmic drugs: Amiodarone, ibutilide and sotalol. In Zipes DP, Jalife J, editors. Cardiac electrophysiology: From cell to bedside. 5th ed. Philadelphia, WB Saunders; 2009: 932-941.
2. Goldschlager N, Epstein AE, Naccarelli GV, et al; Practice Guidelines Sub-committee, North American Society of Pacing and Electrophysiology (HRS). A practical guide for clinicians who treat patients with amiodarone: 2007. Heart Rhythm. 2007;4(9):1250-1259.
3. Lewis JH, Ranard RC, Caruso A, et al. Amiodarone hepatotoxicity: prevalence and clinicopathologic correlations among 104 patients. Hepatology. 1989;9(5):679-685.
4. Richer M, Robert S. Fatal hepatotoxicity following oral administration of amiodarone. Ann Pharmacother. 1995;29(6):582-586.
5. Andrade RJ, Robles M, Fernández-Castañer A, López-Ortega S, López-Vega MC, Lucena MI. Assessment of drug-induced hepatotoxicity in clinical practice: a challenge for gastroenterologists. World J Gastroenterol. 2007;13(3):329-340.
6. Reuben A. Hy's law. Hepatology. 2004;39:574-578.
7. Desai AD, Chun S, Sung RJ. The role of intravenous amiodarone in the management of cardiac arrhythmias. Ann Intern Med. 1997;127(4): 294-303.
8. Gluck N, Fried M, Porat R. Acute amiodarone liver toxicity likely due to ischemic hepatitis. Isr Med Assoc J. 2011;13(12):748-752.
9. Lahbabi M, Aqodad N, Ibrahimi A, Lahlou M, Aqodad H. Acute hepatitis secondary to parenteral amiodarone does not preclude subsequent oral therapy. World J Hepatol. 2012;4(6):196-198.
10. Murphy BP, Coldeway J, Raeside DA. Fatal acute fulminant hepatic failure caused by parenteral amiodarone: A case report and review of the literature. Scott Med J. 2009;54(1):58.
11. Lupon-Rosés J, Simó-Canonge R, Lu-Cortez L, Permanyer-Miralda G, Allende-Monclús H. Probable early acute hepatitis with parenteral amiodarone. Clin Cardiol. 1986;9(5):223-225.
12. Pye M, Northcote RJ, Cobbe SM. Acute hepatitis after parenteral amiodarone administration. Br Heart J. 1988;59(6):690-691.
13. Stevenson RN, Nayani TH, Davies JR. Acute hepatic dysfunction following parenteral amiodarone administration. Postgrad Med J. 1989;65(767):707-708.
14. Simon JP, Zannad F, Trechot P, Thisse JY, Houplon M, Aliot E. Acute hepatitis after a loading dose of intravenous amiodarone. Cardiovasc Drugs Ther. 1990;4(6):1467-1468.
15. Morelli S, Guido V, De Marzio P, Aguglia F, Balsano F. Early hepatitis during intravenous amiodarone administration. Cardiology. 1991; 78(3):291-294.
16. Kalantzis N, Gabriel P, Mouzas J, Tiniakos D, Tsigas D, Tiniakos G. Acute amiodarone-induced hepatitis. Hepatogastroenterology. 1991; 38(1):71-74.
17. Fornaciari G, Monducci I, Barone A, Bassi C, Beltrami M, Tomasi C. Amiodarone-induced acute hepatitis: case report. J Clin Gastroenterol. 1992;15(3):271-273.
18. Rhodes A, Eastwood JB, Smith SA. Early acute hepatitis with parenteral amiodarone: a toxic effect of the vehicle? Gut. 1993;34(4):565-566.
19. Tosetti C, Ongari M, Evangelisti A, Lolli R, Napoli A. Acute hepatotoxicity from amiodarone. Minerva Med. 1995;86(9):387-390. Italian.
20. Paniagua Clusells J, Arcusa Gavalda R, Goma Masip F, Pons Masanes S, Soler Masana JM. Acute hepatitis caused by intravenous amiodarone. Rev Esp Cardiol. 1996;49(5):384-385. Spanish.
21. James PR, Hardman SM. Acute hepatitis complicating parenteral amiodarone does not preclude subsequent oral therapy. Heart.1997;77(6):583-584.
22. Tagliamonte E, Cice G, Ducceschi V, Mayer MS, Iacono A. Acute hepatitis following amiodarone administration. Minerva Cardioangiol. 1997;45(9):451-456. Italian.
23. Breuer HW, Bossek W, Haferland C, Schmidt M, Neumann H, Gruszka J. Amiodarone-induced severe hepatitis mediated by immunological mechanisms. Int J Clin Pharmacol Ther. 1998;36(6):350-352.
24. Iliopoulou A, Giannakopoulos G, Mayrikakis M, Zafiris E, Stamatelopoulos S.Reversible fulminant hepatitis following intravenous amiodarone loading. Amiodarone hepatotoxicity. Int J Clin Pharmacol Ther. 1999;37(6):312-313.
25. López-Gómez D, Nicolás J, Frigola JM, Manito N, Esplugas E. The use of oral amiodarone as a chronic treatment in a patient with prior fulminant hepatitis due to intravenous amiodarone. Rev Esp Cardiol. 1999;52(3):201-203. Spanish.
26. Luengo O, Montero J, Alegre J, Fernández Sevilla T. Toxic hepatitis caused by intravenous amiodarone. Med Clin (Barc). 2000;115(20): 798-799. Spanish.
27. González Galilea A, García Sánchez MV, la Mata García M, Miño Fugarolas G. Early-onset acute toxic hepatitis induced by intravenous amiodarone administration. Gastroenterol Hepatol. 2002; 25(6):392-394. Spanish.
28. Gregory SA, Webster JB, Chapman GD. Acute hepatitis induced by parenteral amiodarone. Am J Med. 2002;113(3):254-255.
29. Agozzino F, Picca M, Pelosi G. Acute hepatitis complicating intravenous amiodarone treatment. Ital Heart J. 2002;3(11):686-688.
30. Giannattasio F, Salvio A, Varriale M, Picciotto FP, Di Costanzo GG, Visconti M. Three cases of severe acute hepatitis after parenteral administration of amiodarone: the active ingredient is not the only agent responsible for hepatotoxicity. Ann Ital Med Int. 2002;17(3): 180-184.
31. Rätz Bravo AE, Drewe J, Schlienger RG, Krähenbühl S, Pargger H, Ummenhofer W. Hepatotoxicity during rapid intravenous loading with amiodarone: Description of three cases and review of the literature. Crit Care Med. 2005;33(1):128-134; discussion 245-246.
32. Cataldi A, Gonella D, Robutti N, Siri M, Buonocore S, Odetti P. Hepatotoxicity after intravenous amiodarone. Aging Clin Exp Res. 2008;20(6):593-596.
33. Grecian R, Ainslie M. Acute hepatic failure following intravenous amiodarone. BMJ Case Rep. 2012;doi:10.1136/bcr-2012-007080.
34. Chan AL, Hsieh HJ, Hsieh YA, Lin SJ. Fatal amiodarone-induced hepatotoxicity: a case report and literature review. Int J Clin Pharmacol Ther. 2008;46:96-101.