Natural killer T cells in adipose tissue are activated in lean mice

Experimental Animals

Volumn 62, Issue 4, 2013, Pages 319-328

  Kondo, Taisuke ^a   Toyoshima, Yujiro ^a   Ishii, Yoshiyuki ^a   Kyuwa, Shigeru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adipose tissue; Diet induced obesity; NKT cell; Repertoire; V

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPIDIDYMIS FAT; INFLAMMATION; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LIPID DIET; LYMPHOCYTE COUNT; MALE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; OBESITY; ORGAN WEIGHT; PROTEIN EXPRESSION; SPLEEN; SUBCUTANEOUS FAT; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TISSUE DISTRIBUTION;

ADIPOSE TISSUE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; INFLAMMATION; INTERFERON-GAMMA; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; NATURAL KILLER T-CELLS; OBESITY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THINNESS;

EID: 84886840700     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.62.319     Document Type: Article

References (34)

1. Bannai, M., Kawamura, T., Naito, T., Kameyama, H., Abe, T., Kawamura, H., Tsukada, C., Watanabe, H., Hatakeya-Ma, K., Hamada, H., Nishiyama, Y., Ishikawa, H., Takeda, K., Okumura, K., Taniguchi, M., and Abo, T. 2001. Abundance of unconventional Cd8(+) natural killer T cells in the large intestine. Eur. J. Immunol. 31: 3361-3369.
2. Brake, D.K. and Smith, C.W. 2008. Flow cytometry on the stromal-vascular fraction of white adipose tissue. Methods Mol. Biol. 456: 221-229.
3. Braun, N.A., Mendez-Fernandez, Y.V., Covarrubias, R., Por-celli, S.A., Savage, P.B., Yagita, H., Van Kaer, L., and Major, A.S. 2010. Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arterioscler. Thromb. Vasc. Biol. 30: 1758-1765.
4. Brutkiewicz, R.R. and Sriram, V. 2002. Natural killer T (nKT) cells and their role in antitumor immunity. Crit. Rev. Oncol. Hematol. 41: 287-298.
5. Caspar-Bauguil, S., Cousin, B., Galinier, A., Segafredo, C., Nibbelink, M., André, M., Casteilla, L., and Pénicaud, L. 2005. Adipose tissues as an ancestral immune organ: site-specific change in obesity. FEBS Lett. 579: 3487-3492.
6. Crowe, N.Y., Coquet, J.M., Berzins, S.P., Kyparissoudis, K., Keating, R., Pellicci, D.G., Hayakawa, Y., Godfrey, D.I., and Smyth, M.J. 2005. Differential antitumor immunity mediated by nKT cell subsets in vivo. J. Exp. Med. 202: 1279-1288.
7. Donath, M.Y. and Shoelson, S.E. 2011. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11: 98-107.
8. Duwaerts, C.C., and Gregory, S.H. 2011. Targeting the diverse immunological functions expressed by hepatic nKT cells. Expert. Opin. Ther. Targets 15: 973-988.
9. Facciotti, F., Ramanjaneyulu, G.S., Lepore, M., Sansano, S., Cavallari, M., Kistowska, M., Forss-Petter, S., Ni, G., Co-lone, A., Singhal, A., Berger, J., Xia, C., Mori, L., and De Libero, G. 2012. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat. Immunol. 13: 474-480.
10. Faulds, M.H. and Dahlman-Wright, K. 2012. Metabolic diseases and cancer risk. Curr. Opin. Oncol. 24: 58-61.
11. Godfrey, D.I., hammond, K.J.L., Poulton, L.D., Smyth, M.J., and Baxter, A.G. 2000. nKT cells: facts, functions and fallacies. Immunol. Today 21: 573-583.
12. Godfrey, D.I., Stankovic, S., and Baxter, A.G. 2010. Raising the nKT cell family. Nat. Immunol. 11: 197-206.
13. Heikkinen, S., Argmann, C.A., Champy, M.F., and Auwerx, J. 2007. Evaluation of glucose homeostasis. Curr. Protoc. Mol. Biol. Chapter 29: unit 29B.3.
14. Hirsch, R., Eckhaus, M., Auchincloss, H., Sachs, D.H., and Bluestone, J.A. 1988. Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. i. immunosuppression of transplantation responses. J. Immunol. 140: 3766-3772.
15. Ibrahim, M.M. 2010. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes. Rev. 11: 11-18.
16. Ishimoto, Y., Tomiyama-miyaji, C., watanabe, H., Yokoya-ma, H., Ebe, K., Tsubata, S., Aoyagi, Y., and Abo, T. 2004. Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive Cd4(+) Cd8(+) cells and B220(+) T cells, in mice. Immunology 113: 371-377.
17. Ji, Y., Sun, S., Xu, A., Bhargava, P., Yang, L., Lam, K.S., Gao, B., Lee, C.H., Kersten, S., and Qi, L. 2012. Activation of natural killer T cells promotes m2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via the iL-4/sTaT6 signaling axis in obesity. J. Biol. Chem. 287: 13561-13571.
18. Kinjo, Y., Illarionov, P., Vela, J.L., Pei, B., Girardi, E., Li, X., Li, Y., Imamura, M., Kaneko, Y., Okawara, A., Yesilka-ya, H., Andrew, P.W., Wong, C.H., Kawakami, K., Nizet, V., Besra, G.S., Tsuji, M., Zajonc, D.M., and Kronenberg, M. 2011. Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat. Immunol. 12: 966-974.
19. Liu, J., Divoux, A., Sun, J., Zhang, J., Clement, K., Glick-Man, J.N., Sukhova, G.K., Wolters, P.J., Du, J., Gorgun, C.Z., Doria, A., Libby, P., Blumberg, R.S., Kahn, B.B., Hota-Misligil, G.S., and Shi, G.P. 2009. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat. Med. 15: 940-945.
20. Ljutic, B., Carlyle, J.R., Filipp, D., Nakagawa, R., Julius, M., and Zuniga-Pfucker, J.C. 2005. Functional requirements for signaling through the stimulatory and inhibitory mouse nKR-P1 (Cd161) nK cell receptors. J. Immunol. 174: 4789-4796.
21. Mantell, B.S., Stefanovic-Racic, M., Yang, X., Dedousis, N., Sipula, I.J., and O'doherty, R.M. 2011. Mice Lacking nKT Cells but with a Complete Complement of Cd8(+) T-Cells are not Protected against the metabolic abnormalities of diet-induced obesity. PLoS ONE 6: e19831.
22. Meyer, E.H., Dekruyff, R.H., and Umetsu, D.T. 2008. T cells and nKT cells in the pathogenesis of asthma. Annu. Rev. Med. 59: 281-292.
23. Middendorp, S., and Nieuwenhuis, E.E.S. 2009. nKT cells in mucosal immunity. Mucosal Immunol. 2: 393-402.
24. Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., Yoshimura, K., Kadowaki, T., and Nagai, R. 2009. Cd8(+) effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15: 914-920.
25. Novak, J., Griseri, T., Beaudoin, L., and Lehuen, A. 2007. Regulation of type 1 diabetes by nKT cells. Int. Rev. Immunol. 26: 49-72.
26. Oh, S.J. and Chung, D.H. 2011. Invariant nKT Cells Producing IL-4 or IL-10, But Not IFN-gamma, Inhibit the Th1 Response in Experimental autoimmune Encephalomyelitis, whereas none of These Cells inhibits the Th17 Response. J. Immunol. 186: 6815-6821.
27. Ohmura, K., Ishimori, N., Ohmura, Y., Tokuhara, S., No-Zawa, A., Horii, S., Andoh, Y., Fujii, S., Iwabuchi, K., Onoe, K., and Tsutsui, H. 2010. Natural Killer T Cells are involved in Adipose Tissues Inflammation and Glucose Intolerance in diet-induced obese mice. Arterioscler. Thromb. Vasc. Biol. 30: 193-199.
28. Osborn, O. and Olefsky, J.M. 2012. The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 18: 363-374.
29. Rhost, S., Sedimbi, S., Kadri, N., and Cardell, S.L. 2012. Immunomodulatory type ii natural killer T (nKT) lymphocytes in health and disease. Scand. J. Immunol. 76: 246-255.
30. Strissel, K.J., DeFuria, J., Shaul, M.E., Bennett, G., Green-Berg, A.S., and Obin, M.S. 2010. T-Cell Recruitment and Th1 Polarization in adipose Tissue during diet-induced obesity in C57BL/6 mice. Obesity (Silver Spring) 18: 1918-1925.
31. Wilson, M.T., Johansson, C., Olivares-Villagómez, D., singh, A.K., Stanic, A.K., Wang, C.R., Joyce, S., Wick, M.J., and Van Kaer, L. 2003. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc. Natl. Acad. Sci. U.S.A. 100: 10913-10918.
32. Winer, D.A., Winer, S., Shen, L., Wadia, P.P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M.G., Alonso, M.N., Leong, H.X., Glassford, A., Caimol, M., Kenkel, J.A., Tedder, T.F., McLaughlin, T., Miklos, D.B., Dosch, H.M., and Engleman, E.G. 2011. B cells promote insulin resistance through modulation of T cells and production of pathogenic igG antibodies. Nat. Med. 17: 610-617.
33. Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bah-Rami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., Maezawa, Y., Drucker, D.J., Engleman, E., Winer, D., and Dosch, H.M. 2009. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15: 921-929.
34. World Health Organisation Fact sheet: obesity and overweight. Available at: http://www.who.int/mediacentre/fact-sheets/fs311/en/print.html. accessed 15 october 2012.