Toxicological analysis of formalin-fixed or embalmed tissues: A review

Forensic Science International

Volumn 233, Issue 1-3, 2013, Pages 312-319

  Nikolaou, Panagiota ^a   Papoutsis, Ioannis ^a   Dona, Artemisia ^a   Spiliopoulou, Chara ^a   Athanaselis, Sotiris ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Embalming; Formalin fixed tissues; Toxicological analysis

Indexed keywords

AMPHETAMINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CHEMICAL COMPOUND; COCAINE; ETHCHLORVYNOL; FORMALDEHYDE; HEAVY METAL; METHADONE; MORPHINE; NEUROLEPTIC AGENT; OPIATE; OPIATE DERIVATIVE; PARAQUAT; PESTICIDE; PHENOBARBITAL; TRACE ELEMENT; VOLATILE AGENT;

ANALYTICAL PARAMETERS; AUTOPSY; BILE; BODY FLUID; BRAIN TISSUE; CADAVER; CHEMICAL ANALYSIS; CHEMICAL ENVIRONMENT; CHEMICAL REACTION; CHEMICAL WASTE; CONCENTRATION RESPONSE; DATA ANALYSIS; DECOMPOSITION; DRUG DETERMINATION; DRUG STABILITY; DRUG USE; EXHUMATION; EXPOSURE; EXTRACTION EFFICIENCY; FORENSIC IDENTIFICATION; FORENSIC PATHOLOGY; FORENSIC TOXICOLOGY; HEART; HISTOPATHOLOGY; HUMAN; INTOXICATION; KIDNEY PARENCHYMA; LIVER; LUNG PARENCHYMA; POSTHUMOUS CARE; PRIORITY JOURNAL; REVIEW; TISSUE CHARACTERIZATION; TISSUE FIXATION; TISSUE PREPARATION; TISSUE PRESERVATION; TISSUE SLICE; URINE;

EMBALMING; FORMALIN-FIXED TISSUES; TOXICOLOGICAL ANALYSIS;

ANALGESICS, OPIOID; CARBON MONOXIDE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CENTRAL NERVOUS SYSTEM STIMULANTS; CYANIDES; DRUG STABILITY; EMBALMING; FIXATIVES; FORENSIC TOXICOLOGY; FORMALDEHYDE; HUMANS; METALS, HEAVY; PESTICIDES; TISSUE DISTRIBUTION; TRACE ELEMENTS;

EID: 84886837604     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2013.10.006     Document Type: Review

References (37)

1. Viel G., Nalesso A., Cecchetto G., Montisci M., Ferrara S.D. Stability of cocaine in formalin solution and fixed tissues. Forensic Sci. Int. 2009, 193:79-83.
2. Alunni-Perret V., Kintz P., Ludes B., Ohayon P., Quatrehomme G. Determination of heroin after embalmment. Forensic Sci. Int. 2003, 134:36-39.
3. Suma R., Sai Prakash P.K. Conversion of sertraline to N-methyl sertraline in embalming fluid: a forensic implication. J. Anal. Toxicol. 2006, 30:395-399.
4. Winek C.L., Esposito F.M., Cinicola D.P. The stability of several compounds in formalin fixed tissues and formalin-blood solutions. Forensic Sci. Int. 1990, 44:159-168.
5. Tracy T.S., Rybeck B.F., James D.G., Knopp J.B., Gannett P.M. Stability of benzodiazepines in formaldehyde solutions. J. Anal. Toxicol. 2001, 25:166-173.
6. Rohrig T.P. Comparison of fentanyl concentrations in unembalmed and embalmed liver samples. J. Anal. Toxicol. 1998, 22:253.
7. Cingolani M., Froldi R., Mencarelli R., Mirtella D., Rodriguez D. Detection and quantification of morphine in fixed tissues and formalin solutions. J. Anal. Toxicol. 2001, 25:31-34.
8. Winek C.L., Zaveri N.R., Wahba W.W. The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions. Forensic Sci. Int. 1993, 61:175-183.
9. Levine B., Wu S.C., Dixon A.M., Smialek J.E. An unusual morphine fatality. Forensic Sci. Int. 1994, 65:7-11.
10. Winek C.L., Wahba W.W., Rozin L., Winek C.L. Determination of ethchlorvynol in body tissues and fluids after embalmment. Forensic Sci. Int. 1988, 37:161-166.
11. Tsoukali-Papadopoulou H. Elucidation of a poisoning case from the analysis of formalin in which brain tissue was preserved. Forensic Sci. Int. 1987, 34:63-65.
12. Kuo T.L., Kuo C.Y. Determination of paraquat from formalin-fixed tissue. Forensic Sci. Int. 1988, 38:243-249.
13. Fransioli M.G., Szabo E.T., Sunshine I. Detection of methadone and propoxyphene in stored tissue. J. Anal. Toxicol. 1980, 4:46-48.
14. Xiang P., Shen M., Bu J., Huang Z. The stability of tetramine, morphine and meperidine in formalin solution. Forensic Sci. Int. 2001, 122:159-162.
15. Cingolani M., Cippitelli M., Froldi R., Gambaro V., Tassoni G. Detection and quantitation analysis of cocaine and metabolites in fixed liver tissues and formalin solutions. J. Anal. Toxicol. 2004, 28:16-19.
16. Hilal A., Daglioglu N., Battal D., Yener F., Daglioglu K. Detection of cocaine and benzoylecgonine in formalin fixed rat tissues. Toxicol. Mech. Methods 2009, 19:422-426.
17. Takayasu T., Ohshima T., Nishigami J., Kondo T., Lin Z., Ohtsuji M., Nagano T. Toxicological analysis for drugs and poisons using the formalin-fixed organ tissues. 1. Methamphetamine. Nihon Hoigaku Zasshi 1994, 48:33-37.
18. Shakleya D.M., Kraner J.C., Kaplan J.A., Gannett P.M., Callery P.S. Identification of N,N-dimethylamphetamine formed by methylation of methamphetamine in formalin-fixed liver tissue by multistage mass spectrometry. Forensic Sci. Int. 2006, 157:87-92.
19. Shakleya D.M., Kraner J.C., Kaplan J.A., Callery P.S. Methylation of 3,4-methylenedioxymethamphetamine in formalin-fixed human liver tissue. J. Anal. Toxicol. 2005, 29:715-717.
20. Tirumalai P.S., Shakleya D.M., Gannett P.M., Callery P.S., Bland T.M., Tracy T.S. Conversion of methamphetamine to N-methyl-methamphetamine in formalin solutions. J. Anal. Toxicol. 2005, 29:48-53.
21. Cingolani M., Cippitelli M., Froldi R., Tassoni G., Mirtella D. Stability of barbiturates in fixed tissues and formalin solutions. J. Anal. Toxicol. 2005, 29:205-208.
22. Gannett P.M., Daft J.R., James D., Rybeck B., Knopp J.B., Tracy T.S. In vitro reaction of barbiturates with formaldehyde. J. Anal. Toxicol. 2001, 25:443-449.
23. Nishigami J., Takayasu T., Ohshima T. Toxicological analysis of the psychotropic drugs chlorpromazine and diazepam using chemically fixed organ tissues. Int. J. Legal Med. 1995, 107:165-170.
24. Yuan J.X., Wang Y.J., Yun K.M. Stability of estazolam in dog tissues preserved in formaldehyde solution. Fa Yi Xue Za Zhi 2011, 27:117-119.
25. Suma R., Shukla S.K., Sai Prakash P.K. Stability study of fluoxetine in formalin-fixed liver tissue. J. Anal. Toxicol. 2006, 30:692-696.
26. Dettling R.J., Briglia E.J., Dal Cortivo L.A., Bidanset J.H. The production of amitriptyline from nortriptyline in formaldehyde-containing solutions. J. Anal. Toxicol. 1990, 14:325-326.
27. Takayasu T., Holterman K., Ohshima T., Pounder D.J. Stability of tricyclic antidepressants in formalin solutions. J.Forensic Sci. 1998, 43:1213-1219.
28. Suma R., Kosanam H., Sai Prakash P.K. Stability study of bupropion and olanzapine in formaldehyde solutions. Rapid Commun. Mass Spectrom. 2006, 20:1390-1394.
29. Pagani S., Mirtella D., Mencarelli R., Rodriguez D., Cingolani M. Postmortem distribution of sildenafil in histological material. J. Anal. Toxicol. 2005, 29:254-257.
30. Kudo K., Nishida N., Kiyoshima A., Ikeda N. A fatal case of poisoning by lidocaine overdosage-analysis of lidocaine in formalin-fixed tissues: a case report. Med. Sci. Law 2004, 44:266-271.
31. Gannett P., Hailu S., Daft J., James D., Rybeck B., Tracy T.S. In vitro reaction of formaldehyde with fenfluramine: conversion to N-methyl fenfluramine. J. Anal. Toxicol. 2001, 25:88-92.
32. Kuo T.L. Release of tissue paraquat into formalin solution during fixation. J. Forensic Sci. 1990, 35:668-674.
33. Minakata K., Suzuki O., Morita T., Asano M. Determination of paraquat in raw and formalin-fixed tissues by electron spin resonance (ESR) spectroscopy. Z. Rechtsmed. 1989, 102:337-345.
34. Cingolani M., Froldi R., Mencarelli R., Rodriguez D. Analytical detection and quantitation of strychnine in chemically fixed organ tissues. J. Anal. Toxicol. 1999, 23:219-221.
35. Takayasu T., Saito K., Nishigami J., Ohshima T., Nagano T. Toxicological analysis of drugs and poisons in formalin-fixed organ tissues. Int. J. Legal Med. 1994, 107:7-12.
36. Bush V.J., Moyer T.P., Batts K.P., Parisi J.E. Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues. Clin. Chem. 1995, 41:284-294.
37. Skopp G. Preanalytic aspects in postmortem toxicology. Forensic Sci. Int. 2005, 142:75-100.