Levomepromazine for nausea and vomiting in palliative care

Cochrane Database of Systematic Reviews

Volumn 2013, Issue 4, 2013, Pages

  Darvill, Emily ^a   Dorman, Saskie ^b   Perkins, Paul ^c  

^a CHELTENHAM GENERAL HOSPITAL   (United Kingdom)

^b POOLE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^c Sue Ryder Care Leckhampton Court Hospice   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOMEPROMAZINE; ANTIEMETIC AGENT;

CLINICAL EVALUATION; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG USE; HUMAN; NAUSEA AND VOMITING; OUTCOME ASSESSMENT; PALLIATIVE THERAPY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SIDE EFFECT; SYSTEMATIC REVIEW; TREATMENT RESPONSE; ADULT; FEMALE; NAUSEA; PREGNANCY; VOMITING;

ADULT; ANTIEMETICS; FEMALE; HUMANS; METHOTRIMEPRAZINE; NAUSEA; PALLIATIVE CARE; PREGNANCY; VOMITING;

EID: 84886809662     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD009420.pub2     Document Type: Review

References (30)

1. Amesbury B, Alloway L, Hickmore E, Dewhurst G. High-dose levomepromazine (methotrimeprazine) to control nausea in carcinoid syndrome. Journal of Palliative Care 2004;20(2):117-8.
2. Eisenchlas J, Garrigue N, Junin M, De Simone G. Low-dose levomepromazine in refractory emesis in advanced cancer patients: an open-label study. Palliative Medicine 2005;19:71-5.
3. Ell C, Konig H, Gutmann W. Prophylaxis of vomiting caused by cytostatic drugs - high dosage of metoclopramide versus antiemetic combination in controlled test [Prophylaxe von zytostatika-bedingtem Erbrechen. Hochdosiertes Metoclolpramid versus Antiemetika-Kombination im kontrollierten Vergleich]. Medizinische Welt 1983;34(35):945-8.
4. Higi M, Niederle N, Schmidt C, Seeber S. Improved antiemetic treatment with levomepromazine [Verbesserte antiemetische Behandlung mit Levomepromazin bei zyotstatikabedingtem Erbrechen]. Deutsche Medizinische Wochenschrift 1980;105(22):794-5.
5. Kennet A, Hardy J, Shah S, A'Hern R. An open study of methotrimeprazine in the management of nausea and vomiting in patients with advanced cancer. Support Cancer Care 2004;13:715-21.
6. Martin M, Diaz-Rubio E, Sanches Duran A, Almenarez J. Pilot study of levomepromazine in treatment of refractory postchemotherapy emesis [Estudio piloto de levomepromazina en el tratamiento de la emesis posquimioterapia refractaria]. Oncologia 1988;11(7):348-51.
7. McCabe H, Maraveyas A. Subcutaneous Levomepromazine Rescue (SLR) for high grade Delayed Chemotherapy-induced Emesis (DCIE). Anticancer Research 2003;23:5209-12.
8. Sgouros J, Neville-Webb H, Bunton S, Lind M, Maraveyas A. Levomepromazine versus dexamethasone with metoclopramide in the prevention of cisplatin induced delayed emesis. Preliminary results of a randomised study. British Journal of Cancer 2003;88:S68.
9. Bentley A, Boyd K. Use of clinical pictures in the management of nausea and vomiting. Palliative Medicine 2001;15:247-53.
10. Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
11. Dahl SG, Strandjord RE, Sigfusson S. Pharmacokinetics and relative bioavailability of levomepromazine after repeated administration of tablets and syrup. European Journal of Clincal Pharmacology 1977;11:305-10.
12. Davis MP, Hallerberg G, Palliative Medicine Study Group of the Multinational Association of Supportive Care in Cancer. A systematic review of the treatment of nausea and/or vomiting in cancer unrelated to chemotherapy or radiation. Journal of Pain and Symptom Management 2010;39(4):702-11.
13. Dietz I, Schmitz A, Lampey I, Schulz C. Evidence for the use of Levomepromazine for symptom control in the palliative care setting: a systematic review. BMC Palliative Care 2013;12:2.
14. Dorman S, Perkins P. Droperidol for treatment of nausea and vomiting in palliative care patients. Cochrane Database of Systematic Reviews 2010, Issue 10. [DOI:].
15. Edmonds P, Karlsen S, Khan S, Addington-Hall J. A comparison of the palliative care needs of patients dying from chronic respiratory diseases and lung cancer. Palliative Medicine 2001;15:287-95.
16. European Association for Palliative Care. http://www.eapcnet.eu/Corporate/AbouttheEAPC/Definitionandaims.aspx (accessed 26 January 2013).
17. Glare P, Pereira G, Kristjanson L, Stockler M, Tattersall M. Systematic review of the efficacy of antiemetics in the treatment of nausea in patients with far-advanced cancer. Supportive Care in Cancer 2004;12:432-40.
18. Grande GE, Todd CJ. Why are trials in palliative care so difficult?. Palliative Medicine 2000;14(1):69-74.
19. Hirst A, Sloan R. Benzodiazepines and related drugs for insomnia in palliative care. Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI:].
20. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al.Assessing the quality of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
21. Keeley PW. Nausea and vomiting in people with cancer and other chronic diseases. Clinical Evidence (online) 2009:2406.
22. Klinkenberg M, Willems DL, van der Wal G, Deeg DJH. Symptom burden in the last week of life. Journal of Pain and Symptom Management 2004;27:5-13.
23. Moore RA, Barden J, Derry S, McQuay HJ. Managing potential publication bias. In: McQuay HJ, Kalso E, Moore RA editor(s). Systematic Reviews in Pain Research: Methodology Refined. Seattle: IASP Press, 2008:15-24.
24. Twycross R, Wilcock A (editors). Levomepromazine. http://www.palliativedrugs.com/levomepromazine.html Added June 2008 (accessed August 2011).
25. Perkins P, Dorman S. Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database of Systematic Reviews 2009, Issue 2. [DOI:].
26. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
27. Skinner J, Skinner A. Levomepromazine for nausea and vomiting in advanced cancer. Hospital Medicine 1999;60(8):568-70.
28. Twycross R, Back I. Nausea and vomiting in advanced cancer. European Journal of Palliative Care 1998;5:39-45.
29. Twycross R, Wilcock A. Palliative Care Formulary (PCF4). Palliativedrugs.com Ltd., 2011.
30. Wee B, Hadley G, Derry S. How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews. BMC Palliative Care 2008;7:13.