Effects of ribavirin dose reduction vs erythropoietin for boceprevir-related anemia in patients with chronic hepatitis C virus genotype 1 infection - A randomized trial

Gastroenterology

Volumn 145, Issue 5, 2013, Pages

  Poordad, Fred ^a   Lawitz, Eric ^a   Reddy, K Rajender ^b   Afdhal, Nezam H ^c   Hézode, Christophe ^d   Zeuzem, Stefan ^e   Lee, Samuel S ^f   Calleja, Jose Luis ^g   Brown Jr , Robert S ^h   Craxi, Antonio ⁱ   Wedemeyer, Heiner ^j   Nyberg, Lisa ^k   Nelson, David R ^l   Rossaro, Lorenzo ^m   Balart, Luis ⁿ   Morgan, Timothy R ^o   Bacon, Bruce R ^p   Flamm, Steven L ^q   Kowdley, Kris V ^r   Deng, Weiping ^s   Koury, Kenneth J ^s   Pedicone, Lisa D ^s   Dutko, Frank J ^s   Burroughs, Margaret H ^s   Alves, Katia ^s   Wahl, Janice ^s   Brass, Clifford A ^s   Albrecht, Janice K ^s   Sulkowski, Mark S ^t   more..

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d HENRI MONDOR HOSPITAL   (France)

^e UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^f UNIVERSITY OF CALGARY   (Canada)

^g HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^h New York Presbyterian Hospital ^*  (United States)

ⁱ UNIVERSITY OF PALERMO   (Italy)

^j HANNOVER MEDICAL SCHOOL   (Germany)

^k KAISER PERMANENTE MEDICAL CENTER   (United States)

^l UNIVERSITY OF FLORIDA   (United States)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ TULANE UNIVERSITY MEDICAL CENTER   (United States)

^o VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^p SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^q NORTHWESTERN UNIVERSITY   (United States)

^r VIRGINIA MASON MEDICAL CENTER   (United States)

^s MERCK RESEARCH LABORATORIES   (United States)

^t JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

DAA; EPO; Erythropoiesis; Side Effect

Indexed keywords

BOCEPREVIR; ERYTHROPOIETIN; HEMOGLOBIN; PEGINTERFERON ALPHA2B; RIBAVIRIN; VIRUS RNA;

ADULT; ADVERSE OUTCOME; ALGORITHM; ALOPECIA; ANEMIA; ARTICLE; CHILL; CHRONIC HEPATITIS; COHORT ANALYSIS; DECREASED APPETITE; DIARRHEA; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG WITHDRAWAL; DYSGEUSIA; ERYTHROCYTE TRANSFUSION; FATIGUE; FEMALE; FEVER; FLU LIKE SYNDROME; HEADACHE; HEMOGLOBIN DETERMINATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INSOMNIA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; NEUTROPENIA; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZATION; RASH; THROMBOCYTE COUNT; THROMBOEMBOLISM; TREATMENT OUTCOME; TREATMENT RESPONSE; VIRUS HEPATITIS; VIRUS LOAD;

EID: 84886803976     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.07.051     Document Type: Article

References (19)

1. H. Tanaka, M. Miyano, and H. Ueda Changes in serum and red blood cell membrane lipids in patients treated with interferon ribavirin for chronic hepatitis C Clin Exp Med 5 2005 190 195
2. M.S. Sulkowski, R. Wasserman, and L. Brooks Changes in haemoglobin during interferon alpha-2b plus ribavirin combination therapy for chronic hepatitis C virus infection J Viral Hepatol 11 2004 243 250
3. J. Morello, S. Rodriguez-Novoa, and I. Jimenez-Nacher Usefulness of monitoring ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C J Antimicrob Chemother 62 2008 1174 1180
4. J.G. McHutchison, E.J. Lawitz, and M.L. Shiffman Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection N Engl J Med 361 2009 580 593
5. I.M. Jacobson, R.S. Brown Jr., and B. Freilich Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial Hepatology 46 2007 971 981
6. M.G. Ghany, D.R. Nelson, and D.B. Strader An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases Hepatology 54 2011 1433 1444
7. EASL Clinical Practice Guidelines: management of hepatitis C virus infection J Hepatol 55 2011 245 264
8. M.L. Shiffman, M.G. Ghany, and T.R. Morgan Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C Gastroenterology 132 2007 103 112
9. J.G. McHutchison, M. Manns, and K. Patel Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C Gastroenterology 123 2002 1061 1069
10. F. Poordad, B. Bacon, and S. Bruno Boceprevir for untreated chronic HCV genotype 1 infection N Engl J Med 364 2011 1195 1206
11. B. Bacon, S. Gordon, and E. Lawitz Boceprevir for previously treated chronic HCV genotype 1 infection N Engl J Med 364 2011 1207 1217
12. I.M. Jacobson, J.G. McHutchison, and G. Dusheiko Telaprevir for previously untreated chronic hepatitis C virus infection N Engl J Med 364 2011 2405 2416
13. S. Zeuzem, P. Andreone, and S. Pol Telaprevir for retreatment of HCV infection N Engl J Med 364 2011 2417 2428
14. M.S. Sulkowski, F. Poordad, and M.P. Manns Anemia during treatment with peginterferon alfa-2b/ribavirin and boceprevir: analysis from the Serine Protease Inhibitor Therapy 2 (SPRINT-2) trial Hepatology 57 2013 974 984
15. D.T. Dieterich, R. Wasserman, and N. Brau Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa Am J Gastroenterol 98 2003 2491 2499
16. N.H. Afdhal, D.T. Dieterich, and P.J. Pockros Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study Gastroenterology 126 2004 1302 1311
17. P.Y. Kwo, E.J. Lawitz, and J. McCone Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial Lancet 376 2010 705 716
18. P. Glue The clinical pharmacology of ribavirin Semin Liver Dis 19 Suppl 1 1999 17 24
19. L. Barbera, and G. Thomas Erythropoiesis stimulating agents, thrombosis and cancer Radiother Oncol 95 2010 269 276