Incidence and long-term risk of de novo malignancies after liver transplantation with implications for prevention and detection

Liver Transplantation

Volumn 19, Issue 11, 2013, Pages 1252-1261

  Schrem, Harald ^a   Kurok, Marlene ^b   Kaltenborn, Alexander ^a,c   Vogel, Arndt ^a   Walter, Ulla ^a   Zachau, Lea ^a   Manns, Michael P ^a   Klempnauer, Jürgen ^a   Kleine, Moritz ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b NORDSTADT HOSPITAL   (Germany)

^c Federal Armed Forces Medical Center Hannover   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS;

ACUTE LIVER FAILURE; ADULT; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; ARTICLE; AUTOIMMUNE HEPATITIS; BLADDER CANCER; BREAST CANCER; BUDD CHIARI SYNDROME; CANCER DIAGNOSIS; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CANCER SURVIVAL; CAROLI DISEASE; COLORECTAL CANCER; ENDOMETRIUM CANCER; ESOPHAGUS CANCER; FEMALE; GERMANY; HEPATITIS B; HEPATITIS C; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY CARCINOMA; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; LUNG CANCER; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; NONHODGKIN LYMPHOMA; OVARY CANCER; PANCREAS CANCER; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROSTATE CANCER; STOMACH CANCER; TESTIS CANCER; THYROID CANCER; TUMOR GROWTH; UTERINE CERVIX CANCER; VULVA CARCINOMA; AGED; INCIDENCE; MIDDLE AGED; NEOPLASMS; RISK; TIME;

AGED; FEMALE; HUMANS; IMMUNOSUPPRESSION; INCIDENCE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; NEOPLASMS; RISK; TIME FACTORS;

EID: 84886798020     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.23722     Document Type: Article

References (36)

1. Haagsma EB, Hagens VE, Schaapveld M, van den Berg AP, de Vries EG, Klompmaker IJ, et al. Increased cancer risk after liver transplantation: a population-based study. J Hepatol 2001; 34: 84-91.
2. Aberg F, Pukkala E, Höckerstedt K, Sankila R, Isoniemi H,. Risk of malignant neoplasms after liver transplantation: a population-based study. Liver Transpl 2008; 14: 1428-1436.
3. Jiang Y, Villeneuve PJ, Fenton SS, Schaubel DE, Lilly L, Mao Y,. Liver transplantation and subsequent risk of cancer: findings from a Canadian cohort study. Liver Transpl 2008; 14: 1588-1597.
4. Tjon AS, Sint Nicolaas J, Kwekkeboom J, de Man RA, Kazemier G, Tilanus HW, et al. Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: an association with C2 monitoring and recipient age. Liver Transpl 2010; 16: 837-846.
5. Oo YH, Gunson BK, Lancashire RJ, Cheng KK, Neuberger JM,. Incidence of cancers following orthotopic liver transplantation in a single center: comparison with national cancer incidence rates for England and Wales. Transplantation 2005; 80: 759-764.
6. Sheiner PA, Magliocca JF, Bodian CA, Kim-Schluger L, Altaca G, Guarrera JV, et al. Long-term medical complications in patients surviving > or = 5 years after liver transplant. Transplantation 2000; 69: 781-789.
7. Collett D, Mumford L, Banner NR, Neuberger J, Watson C,. Comparison of the incidence of malignancy in recipients of different types of organ: a UK registry audit. Am J Transplant 2010; 10: 1889-1896.
8. Finkenstedt A, Graziadei IW, Oberaigner W, Hilbe W, Nachbaur K, Mark W, et al. Extensive surveillance promotes early diagnosis and improved survival of de novo malignancies in liver transplant recipients. Am J Transplant 2009; 9: 2355-2361.
9. Baccarani U, Piselli P, Serraino D, Adani GL, Lorenzin D, Gambato M, et al. Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries. Dig Liver Dis 2010; 42: 55-60.
10. Benlloch S, Berenguer M, Prieto M, Moreno R, San Juan F, Rayõn M, et al. De novo internal neoplasms after liver transplantation: increased risk and aggressive behavior in recent years? Am J Transplant 2004; 4: 596-604.
11. Chak E, Saab S,. Risk factors and incidence of de novo malignancy in liver transplant recipients: a systematic review. Liver Int 2010; 30: 1247-1258.
12. Herrero JI, Lorenzo M, Quiroga J, Sangro B, Pardo F, Rotellar F, et al. De novo neoplasia after liver transplantation: an analysis of risk factors and influence on survival. Liver Transpl 2005; 11: 89-97.
13. Robert Koch Institute. German Centre for Cancer Registry Data. http://www.rki.de/EN/Content/Institute/DepartmentsUnits/EpidemHealthReprting/ ZFKD/ZFKD-node.html. Accessed July 2013.
14. Sanchez EQ, Marubashi S, Jung G, Levy MF, Goldstein RM, Molmenti EP, et al. De novo tumors after liver transplantation: a single-institution experience. Liver Transpl 2002; 8: 285-291.
15. Ferlay J, Parkin DM, Steliarova-Foucher E,. Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 2010; 46: 765-781.
16. Canavan TP, Cohen D,. Vulvar cancer. Am Fam Physician 2002; 66: 1269-1274.
17. Wolke AM, Schaffner F, Kapelman B, Sacks HS,. Malignancy in primary biliary cirrhosis. High incidence of breast cancer in affected women. Am J Med 1984; 76: 1075-1078.
18. Jiménez C, Manrique A, Marqués E, Ortega P, Loinaz C, Gõmez R, et al. Incidence and risk factors for the development of lung tumors after liver transplantation. Transpl Int 2007; 20: 57-63.
19. Saigal S, Norris S, Muiesan P, Rela M, Heaton N, O'Grady J,. Evidence of differential risk for posttransplantation malignancy based on pretransplantation cause in patients undergoing liver transplantation. Liver Transpl 2002; 8: 482-487.
20. Presser SJ, Schumacher G, Neuhaus R, Thuss-Patience P, Stieler J, Neuhaus P,. De novo esophageal neoplasia after liver transplantation. Liver Transpl 2007; 13: 443-450.
21. Herrero JI, Pardo F, D'Avola D, Alegre F, Rotellar F, Iñarrairaegui M, et al. Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation: the effect of smoking withdrawal. Liver Transpl 2011; 17: 402-408.
22. Broomé U, Bergquist A,. Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer. Semin Liver Dis 2006; 26: 31-41.
23. Fung JJ, Jain A, Kwak EJ, Kusne S, Dvorchik I, Eghtesad B,. De novo malignancies after liver transplantation: a major cause of late death. Liver Transpl 2001; 7 (suppl 1): S109-S118.
24. Lamberti C, Lundin S, Bogdanow M, Gorschlüter M, Schmidt-Wolf IG, Sauerbruch T,. Adjuvant and palliative chemotherapy of colorectal cancer in Germany outside controlled trials [in German]. Dtsch Med Wochenschr 2006; 131: 485-490.
25. Zauber AG, Lansdorp-Vogelaar I, Knudsen AB, Wilschut J, van Ballegooijen M, Kuntz KM,. Evaluating test strategies for colorectal cancer screening: a decision analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2008; 149: 659-669.
26. Pastorino U,. Lung cancer screening. Br J Cancer 2010; 102: 1681-1686.
27. Swinnen LJ,. Treatment of organ transplant-related lymphoma. Hematol Oncol Clin North Am 1997; 11: 963-973.
28. Kamdar KY, Rooney CM, Heslop HE,. Posttransplant lymphoproliferative disease following liver transplantation. Curr Opin Organ Transplant 2011; 16: 274-280.
29. US Preventive Services Task Force. Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2009; 151: 716-726.
30. Schulz KD, Kreienberg R, Fischer R, Albert US,; for Deutsche Gesellschaft für Senologie, Deutsche Krebsgesellschaft, and Deutsche Krebshilfe und die Mitglieder der Plangungskommission. Stage 3 recommendations-the early recognition of breast cancer in Germany. Abridged version for medical practitioners [in German]. Radiologe 2003; 43: 495-502.
31. Adami J, Gäbel H, Lindelöf B, Ekström K, Rydh B, Glimelius B, et al. Cancer risk following organ transplantation: a nationwide cohort study in Sweden. Br J Cancer 2003; 89: 1221-1227.
32. Ansink A,. Vulvar squamous cell carcinoma. Semin Dermatol 1996; 15: 51-59.
33. Madeleine MM, Daling JR, Carter JJ, Wipf GC, Schwartz SM, McKnight B, et al. Cofactors with human papillomavirus in a population-based study of vulvar cancer. J Natl Cancer Inst 1997; 89: 1516-1523.
34. Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, et al. Global burden of human papillomavirus and related diseases. Vaccine 2012; 30 (suppl 5): F12-F23.
35. Gross G, Gissmann L, Hillemanns P, Ikenberg H, Kaufmann AM, Petry KU, et al.; for HPV-Management Forum. Prevention of HPV-associated neoplasias by vaccination-short version of the German S3 (level 3) guideline [in German]. Dtsch Med Wochenschr 2010; 135: 1083-1086.
36. Lucey MR, Terrault N, Ojo L, Hay JE, Neuberger J, Blumberg E, Teperman LW,. Long-term management of the successful adult liver transplant: 2012 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Liver Transpl 2013; 19: 3-26.