HCC patients suffer less from geographic differences in organ availability

American Journal of Transplantation

Volumn 13, Issue 11, 2013, Pages 2989-2995

  Schuetz, C ^a   Dong, N ^a   Smoot, E ^a   Elias, N ^a   Schoenfeld, D A ^a   Markmann, J F ^a   Yeh, H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

donation service area; Hepatocellular carcinoma; liver transplantation; MELD score; organ allocation

Indexed keywords

ADULT; ARTICLE; CANCER MORTALITY; CANCER PATIENT; CONTROLLED STUDY; FEMALE; GEOGRAPHIC DISTRIBUTION; GRAFT RECIPIENT; HOSPITAL ADMISSION; HUMAN; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; PRIORITY JOURNAL; RISK ASSESSMENT;

DONATION SERVICE AREA; HEPATOCELLULAR CARCINOMA; LIVER TRANSPLANTATION; MELD SCORE; ORGAN ALLOCATION;

CARCINOMA, HEPATOCELLULAR; END STAGE LIVER DISEASE; FEMALE; GEOGRAPHY; HEALTH SERVICES ACCESSIBILITY; HUMANS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PATIENT SELECTION; PROGNOSIS; RISK FACTORS; SURVIVAL RATE; TIME FACTORS; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS; WAITING LISTS;

EID: 84886794974     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12441     Document Type: Article

References (27)

1. Said A, Williams J, Holden J, et al. Model for end stage liver disease score predicts mortality across a broad spectrum of liver disease. J Hepatol 2004; 40: 897-903.
2. Freeman RB Jr, Steffick DE, Guidinger MK, Farmer DG, Berg CL, Merion RM., Liver and intestine transplantation in the United States, 1997-2006. Am J Transplant 2008; 8: 958-976.
3. Ioannou GN, Perkins JD, Carithers RL Jr., Liver transplantation for hepatocellular carcinoma: Impact of the MELD allocation system and predictors of survival. Gastroenterology 2008; 134: 1342-1351.
4. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693-699.
5. Toso C, Dupuis-Lozeron E, Majno P, et al. A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waitinglist. Hepatology 2012; 56: 149-156.
6. Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival. Hepatology 2001; 33: 1394-1403.
7. Yeh H, Smoot E, Schoenfeld DA, Markmann JF., Geographic inequity in access to livers for transplantation. Transplantation 2011; 91: 479-486.
8. Freeman RB Jr, Wiesner RH, Harper A, et al. The new liver allocation system: Moving toward evidence-based transplantation policy. Liver Transpl 2002; 8: 851-858.
9. Kamath PS, Kim WR., The model for end-stage liver disease (MELD). Hepatology 2007; 45: 797-805.
10. Pomfret EA, Washburn K, Wald C, et al. Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States. Liver Transpl 2010; 16: 262-278.
11. UNOS/OPTN. Liver allocation policy. § 3.6.4.4. December 13, 2012. Available at: http://optn.transplant.hrsa.gov/PoliciesandBylaws2/policies/pdfs/ policy-8.pdf. Accessed February 14, 2013.
12. Cheng SJ, Freeman RB Jr, Wong JB., Predicting the probability of progression-free survival in patients with small hepatocellular carcinoma. Liver Transpl 2002; 8: 323-328.
13. Sharma P, Balan V, Hernandez JL, et al. Liver transplantation for hepatocellular carcinoma: The MELD impact. Liver Transpl 2004; 10: 36-41.
14. Volk ML., Unfair priority for HCC: A problem whose ideal solution remains unsolved. Am J Transplant 2010; 10: 1507-1508.
15. Washburn K, Edwards E, Harper A, Freeman R., Hepatocellular carcinoma patients are advantaged in the current liver transplant allocation system. Am J Transplant 2010; 10: 1643-1648.
16. Goldberg D, French B, Abt P, Feng S, Cameron AM., Increasing disparity in waitlist mortality rates with increased model for end-stage liver disease scores for candidates with hepatocellular carcinoma versus candidates without hepatocellular carcinoma. Liver Transpl 2012; 18: 434-443.
17. Massie AB, Caffo B, Gentry SE, et al. MELD exceptions and rates of waitinglist outcomes. Am J Transplant 2011; 11: 2362-2371.
18. Northup PG, Berg CL., Hepatocellular carcinoma and model for end-stage liver disease exceptions: The more we understand, the more challenging the allocation gets. Liver Transpl 2012; 18: 381-383.
19. Yao FY, Bass NM, Nikolai B, et al. A follow-up analysis of the pattern and predictors of dropout from the waitinglist for liver transplantation in patients with hepatocellular carcinoma: Implications for the current organ allocation policy. Liver Transpl 2003; 9: 684-692.
20. Dzebisashvili N, Massie AB, Lentine KL, et al. Following the organ supply: Assessing the benefit of inter-DSA travel in liver transplantation. Transplantation 2013; 95: 361-371.
21. Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: The concept of a donor risk index. Am J Transplant 2006; 6: 783-790.
22. Chen JW, Kow L, Verran DJ, et al. Poorer survival in patients whose explanted hepatocellular carcinoma (HCC) exceeds Milan or UCSF criteria. An analysis of liver transplantation in HCC in Australia and New Zealand. HPB (Oxford) 2009; 11: 81-89.
23. Duffy JP, Vardanian A, Benjamin E, et al. Liver transplantation criteria for hepatocellular carcinoma should be expanded: A 22-year experience with 467 patients at UCLA. Ann Surg 2007; 246: 502-509, discussion 509-511.
24. Yao FY, Xiao L, Bass NM, Kerlan R, Ascher NL, Roberts JP., Liver transplantation for hepatocellular carcinoma: Validation of the UCSF-expanded criteria based on preoperative imaging. Am J Transplant 2007; 7: 2587-2596.
25. Cucchetti A, Cescon M, Bigonzi E, et al. Priority of candidates with hepatocellular carcinoma awaiting liver transplantation can be reduced after successful bridge therapy. Liver Transpl 2011; 17: 1344-1354.
26. Zhang M, Yin F, Chen B, et al. Mortality risk after liver transplantation in hepatocellular carcinoma recipients: A nonlinear predictive model. Surgery 2012; 151: 889-897.
27. Park SJ, Freise CE, Hirose R, et al. Risk factors for liver transplant waitlist dropout in patients with hepatocellular carcinoma. Clin Transplant 2012; 26: E359-E364.