Characterization of sil in invasive group A and G streptococci: Antibodies against bacterial pheromone peptide SilCR result in severe infection

Infection and Immunity

Volumn 81, Issue 11, 2013, Pages 4121-4127

  Michael Gayego, Ayelet ^a   Dan Goor, Mary ^b   Jaffe, Joseph ^a   Hidalgo Grass, Carlos ^a   Moses, Allon E ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

FREUND ADJUVANT; GENOMIC DNA; INTERLEUKIN 8; PHEROMONE; SILCR PEPTIDE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BETA HEMOLYTIC STREPTOCOCCUS; CELL MIGRATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE LOCUS; HISTOLOGY; IMMUNE RESPONSE; MOUSE; NECROTIZING FASCIITIS; NONHUMAN; OPEN READING FRAME; PEPTIDE ANALYSIS; POLYMERASE CHAIN REACTION; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; QUORUM SENSING; SILC GENE; SOUTHERN BLOTTING; STREPTOCOCAL INVASION LOCUS; STREPTOCOCCUS GROUP A; STREPTOCOCCUS GROUP G; STREPTOCOCCUS INFECTION; TISSUE NECROSIS; VACCINATION; WOUND INFECTION;

ANIMALS; ANTIBODIES, BACTERIAL; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; MICE; MICE, INBRED BALB C; PEPTIDES; PHEROMONES; QUORUM SENSING; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS; VIRULENCE; VIRULENCE FACTORS;

EID: 84886781082     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00359-13     Document Type: Article

References (29)

1. Lancefield RC, Hare R. 1935. The serological differentiation of pathogenic and non-pathogenic strains of hemolytic streptococci from parturient women. J. Exp. Med. 61:335-349.
2. Vartian C, Lerner PI, Shlaes DM, Gopalakrishna KV. 1985. Infections due to Lancefield group G streptococci. Medicine (Baltimore) 64:75-88.
3. Cohen-Poradosu R, Jaffe J, Lavi D, Grisariu-Greenzaid S, Nir-Paz R, Valinsky L, Dan-Goor M, Block C, Beall B, Moses AE. 2004. Group G streptococcal bacteremia in Jerusalem. Emerg. Infect. Dis. 10:1455-1460.
4. Bisno AL, Craven DE, McCabe WR. 1987. M proteins of group G streptococci isolated from bacteremic human infections. Infect. Immun. 55:753-757.
5. Cleary PP, Peterson J, Chen C, Nelson C. 1991. Virulent human strains of group G streptococci express a C5a peptidase enzyme similar to that produced by group A streptococci. Infect. Immun. 59:2305-2310.
6. Igwe EI, Shewmaker PL, Facklam RR, Farley MM, van Beneden C, Beall B. 2003. Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans. FEMS Microbiol. Lett. 229:259-264.
7. Jones KF, Fischetti VA. 1987. Biological and immunochemical identity of M protein on group G streptococci with M protein on group A streptococci. Infect. Immun. 55:502-506.
8. Kalia A, Bessen DE. 2003. Presence of streptococcal pyrogenic exotoxin A and C genes in human isolates of group G streptococci. FEMS Microbiol. Lett. 219:291-295.
9. Simpson WJ, Robbins JC, Cleary PP. 1987. Evidence for group A-related Mprotein genes in human but not animal-associated group G streptococcal pathogens. Microb. Pathog. 3:339-350.
10. Hidalgo-Grass C, Ravins M, Dan-Goor M, Jaffe J, Moses AE, Hanski E.2002. A locus of group A Streptococcus involved in invasive disease and DNA transfer. Mol. Microbiol. 46:87-99.
11. Havarstein LS, Coomaraswamy G, Morrison DA. 1995. An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. U. S. A. 92: 11140-11144.
12. Beres SB, Richter EW, Nagiec MJ, Sumby P, Porcella SF, DeLeo FR, Musser JM. 2006. Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus. Proc. Natl. Acad. Sci. U. S. A. 103:7059-7064.
13. Smoot JC, Barbian KD, Van Gompel JJ, Smoot LM, Chaussee MS, Sylva GL, Sturdevant DE, Ricklefs SM, Porcella SF, Parkins LD, Beres SB, Campbell DS, Smith TM, Zhang Q, Kapur V, Daly JA, Veasy LG, Musser JM. 2002. Genome sequence and comparative microarray analysis of serotype M18 groupAStreptococcus strains associated with acute rheumatic fever outbreaks. Proc. Natl. Acad. Sci. U. S. A. 99:4668-4673.
14. Bessen DE, Kumar N, Hall GS, Riley DR, Luo F, Lizano S, Ford CN, McShan WM, Nguyen SV, Dunning Hotopp JC, Tettelin H. 2011. Whole-genome association study on tissue tropism phenotypes in group A Streptococcus. J. Bacteriol. 193:6651-6663.
15. Hidalgo-Grass C, Dan-Goor M, Maly A, Eran Y, Kwinn LA, Nizet V, Ravins M, Jaffe J, Peyser A, Moses AE, Hanski E. 2004. Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections. Lancet 363:696-703.
16. Moses AE, Goldberg S, Korenman Z, Ravins M, Hanski E, Shapiro M. 2002. Invasive group a streptococcal infections, Israel. Emerg. Infect. Dis. 8:421-426.
17. Moses AE, Hidalgo-Grass C, Dan-Goor M, Jaffe J, Shetzigovsky I, Ravins M, Korenman Z, Cohen-Poradosu R, Nir-Paz R. 2003. emm typing ofMnontypeable invasive group A streptococcal isolates in Israel. J. Clin. Microbiol. 41:4655-4659.
18. Nir-Paz R, Block C, Shasha D, Korenman Z, Gorodnitzky Z, Jaffe J, Ron M, Michael-Gayego A, Cohen-Poradosu R, Shapiro M, Moses AE. 2006. Macrolide, lincosamide and tetracycline susceptibility and emm characterisation of invasive Streptococcus pyogenes isolates in Israel. Int. J. Antimicrob. Agents 28:313-319.
19. Caparon MG, Scott JR. 1991. Genetic manipulation of pathogenic streptococci. Methods Enzymol. 204:556-586.
20. Southern EM. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503-517.
21. Wu DY, Ugozzoli L, Pal BK, Wallace RB. 1989. Allele-specific enzymatic amplification of beta-globin genomic DNA for diagnosis of sickle cell anemia. Proc. Natl. Acad. Sci. U. S. A. 86:2757-2760.
22. Kalia A, Enright MC, Spratt BG, Bessen DE. 2001. Directional gene movement from human-pathogenic to commensal-like streptococci. Infect. Immun. 69:4858-4869.
23. Humar D, Datta V, Bast DJ, Beall B, De Azavedo JC, Nizet V. 2002. Streptolysin S and necrotising infections produced by groupGstreptococcus. Lancet 359:124-129.
24. Sachse S, Seidel P, Gerlach D, Gunther E, Rodel J, Straube E, Schmidt KH. 2002. Superantigen-like gene(s) in human pathogenic Streptococcus dysgalactiae, subsp equisimilis: genomic localisation of the gene encoding streptococcal pyrogenic exotoxin G (speG(dys)). FEMS Immunol. Med. Microbiol. 34:159-167.
25. Bidet P, Courroux C, Salgueiro C, Carol A, Mariani-Kurkdjian P, Bonacorsi S, Bingen E. 2007. Molecular epidemiology of the sil streptococcal invasive locus in group A streptococci causing invasive infections in French children. J. Clin. Microbiol. 45:2002-2004.
26. Belotserkovsky I, Baruch M, Peer A, Dov E, Ravins M, Mishalian I, Persky M, Smith Y, Hanski E. 2009. Functional analysis of the quorumsensing streptococcal invasion locus (sil). PLoS Pathog. 5:e1000651. doi: 10.1371/journal.ppat.1000651.
27. Federle MJ, Bassler BL. 2003. Interspecies communication in bacteria. J. Clin. Invest. 112:1291-1299.
28. Kleerebezem M, Quadri LE, Kuipers OP, de Vos WM. 1997. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol. Microbiol. 24:895-904.
29. Eran Y, Getter Y, Baruch M, Belotserkovsky I, Padalon G, Mishalian I, Podbielski A, Kreikemeyer B, Hanski E. 2007. Transcriptional regulation of the sil locus by the SilCR signalling peptide and its implications on group A streptococcus virulence. Mol. Microbiol. 63:1209-1222.