microRNA-449a functions as a tumor-suppressor in gastric adenocarcinoma by targeting Bcl-2

Oncology Letters

Volumn 6, Issue 6, 2013, Pages 1713-1718

  Wei, Bin ^a   Song, Ying ^b   Zhang, Yonghong ^a   Hu, Mingjun ^a  

^a First Hosp of Xi'an Jiaotong Univ   (China)

^b XI AN CENTRAL HOSPITAL   (China)

Author keywords

Apoptosis; Bcl 2; Caspase 3; Caspase 7; Gastric adenocarcinoma; miR 449a

Indexed keywords

CASPASE 3; CASPASE 7; CHOLECYSTOKININ OCTAPEPTIDE; LUCIFERASE; MICRORNA; MICRORNA 449; PROTEIN BCL 2; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; NICK END LABELING; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SPECTROFLUOROMETRY; STOMACH ADENOCARCINOMA; WESTERN BLOTTING;

EID: 84886774789     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1609     Document Type: Article

References (30)

1. Yang L: Incidence and mortality of gastric cancer in China. World J Gastroenterol 12: 17-20, 2006.
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917, 2010.
3. Saeki N, Ono H, Sakamoto H and Yoshida T: Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study. Cancer Sci 104: 1-8, 2013.
4. Kim K, Chun KH, Suh PG and Kim IH: Alterations in cell proliferation related gene expressions in gastric cancer. Crit Rev Eukaryot Gene Expr 21: 237-254, 2011.
5. Lee S and Vasudevan S: Post-transcriptional stimulation of gene expression by microRNAs. Adv Exp Med Biol 768: 97-126, 2013.
6. Peralta-Zaragoza O, Bermudez-Morales VH and Madrid-Marina V: RNA interference: biogenesis molecular mechanisms and its applications in cervical cancer. Rev Invest Clin 62: 63-80, 2010 (In Spanish).
7. Du L and Pertsemlidis A: microRNA regulation of cell viability and drug sensitivity in lung cancer. Expert Opin Biol Ther 12: 1221-1239, 2012.
8. Segura MF, Greenwald HS, Hanniford D, Osman I and Hernando E: MicroRNA and cutaneous melanoma: from discovery to prognosis and therapy. Carcinogenesis 33: 1823-1832, 2012.
9. Menendez P, Villarejo P, Padilla D, Menendez JM and Montes JA: Diagnostic and prognostic significance of serum microRNAs in colorectal cancer. J Surg Oncol 107: 217-220, 2013.
10. Liu H: MicroRNAs in breast cancer initiation and progression. Cell Mol Life Sci 69: 3587-3599, 2012.
11. Oulas A, Boutla A, Gkirtzou K, Reczko M, Kalantidis K and Poirazi P: Prediction of novel microRNA genes in cancer-associated genomic regions-a combined computational and experimental approach. Nucleic Acids Res 37: 3276-3287, 2009.
12. Peng S, Zeng X, Li X, Peng X and Chen L: Multi-class cancer classification through gene expression profiles: microRNA versus mRNA. J Genet Genomics 36: 409-416, 2009.
13. Thiel A and Ristimaki A: Gastric cancer: basic aspects. Helicobacter 17 Suppl 1: 26-29, 2012.
14. Sezer C, Yildirim M, Yildiz M, Sezgin A, Donem Dilli U, Goktas S and Bulbuller N: Prognostic significance of biological apoptosis factors in gastric cancer. J BUON 18: 138-146, 2013.
15. Amir S, Ma AH, Shi XB, Xue L, Kung HJ and Devere White RW: Oncomir miR-125b suppresses p14(ARF) to modulate p53-dependent and p53-independent apoptosis in prostate cancer. PLoS One 8: e61064, 2013.
16. Chio CC, Lin JW, Cheng HA, Chiu WT, Wang YH, Wang JJ, Hsing CH and Chen RM: MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells. Arch Toxicol 87: 459-468, 2013.
17. Zhang H, Li Y, Huang Q, Ren X, Hu H, Sheng H and Lai M: MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death Differ 18: 1702-1710, 2011.
18. Roth C, Pantel K, Muller V, Rack B, Kasimir-Bauer S, Janni W and Schwarzenbach H: Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression. BMC Cancer 11: 4, 2011.
19. Wang PY, Li YJ, Zhang S, Li ZL, Yue Z, Xie N and Xie SY: Regulating A549 cells growth by ASO inhibiting miRNA expression. Mol Cell Biochem 339: 163-171, 2010.
20. Hoshyar R, Bathaie SZ and Sadeghizadeh M: Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells. DNA Cell Biol 32: 50-57, 2013.
21. Hsu KW, Hsieh RH, Huang KH, Fen-Yau Li A, Chi CW, Wang TY, Tseng MJ, Wu KJ and Yeh TS: Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. Carcinogenesis 33: 1459-1467, 2012.
22. Yu JW, Wu JG, Zheng LH, Zhang B, Ni XC, Li XQ and Jiang BJ: Influencing factors and clinical significance of the metastatic lymph nodes ratio in gastric adenocarcinoma. J Exp Clin Cancer Res 28: 55, 2009.
23. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
24. Ali Z, Deng Y and Ma C: Progress of research in gastric cancer. J Nanosci Nanotechnol 12: 8241-8248, 2012.
25. Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR and Zhao Q: MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. FEBS Lett 585: 1363-1367, 2011.
26. Skinnider BF, Horsman DE, Dupuis B and Gascoyne RD: Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities. Hum Pathol 30: 803-808, 1999.
27. Korbakis D and Scorilas A: Quantitative expression analysis of the apoptosis-related genes BCL2, BAX and BCL2L12 in gastric adenocarcinoma cells following treatment with the anticancer drugs cisplatin, etoposide and taxol. Tumour Biol 33: 865-875, 2012.
28. Zimmermann KC, Bonzon C and Green DR: The machinery of programmed cell death. Pharmacol Ther 92: 57-70, 2001.
29. Song KY, Jung CK, Park WS and Park CH: Expression of the antiapoptosis gene Survivin predicts poor prognosis of stage III gastric adenocarcinoma. Jpn J Clin Oncol 39: 290-296, 2009.
30. Boominathan L: The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One 5: e10615, 2010.