Detecting alcohol abuse: Traditional blood alcohol markers compared to ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) measurement in hair

Forensic Science, Medicine, and Pathology

Volumn 9, Issue 4, 2013, Pages 471-477

  Hastedt, Martin ^a   Büchner, Mara ^a   Rothe, Michael ^b   Gapert, René ^a,c   Herre, Sieglinde ^a   Krumbiegel, Franziska ^a   Tsokos, Michael ^a   Kienast, Thorsten ^d   Heinz, Andreas ^d   Hartwig, Sven ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b LIPIDOMIX GMBH   (Germany)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Alanine amino transferase (ALT); Alcohol consumption diagnosis; Aspartate amino transferase (AST); Biomarkers; Carbohydrate deficient transferrin (CDT); Chronic excessive alcohol intake; Cut off values; Gamma glutamyl transferase (GGT); Hair analysis

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; CARBOHYDRATE DEFICIENT TRANSFERRIN; CARBOHYDRATE-DEFICIENT TRANSFERRIN; DRUG DERIVATIVE; ESTER; ETHYL GLUCURONIDE; FATTY ACID; GAMMA GLUTAMYLTRANSFERASE; GLUCURONIC ACID; TRANSFERRIN;

ALCOHOLISM; AREA UNDER THE CURVE; ARTICLE; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COMPARATIVE STUDY; HAIR; HUMAN; LABORATORY DIAGNOSIS; METABOLISM; METHODOLOGY; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; SUBSTANCE ABUSE;

ALCOHOLISM; AREA UNDER CURVE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; ESTERS; ETHANOL; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; FATTY ACIDS; GAMMA-GLUTAMYLTRANSFERASE; GLUCURONATES; HAIR; HUMANS; PREDICTIVE VALUE OF TESTS; ROC CURVE; SUBSTANCE ABUSE DETECTION; TRANSFERRIN;

EID: 84886751487     PISSN: 1547769X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12024-013-9416-8     Document Type: Article

References (22)

1. World Health Organisation. Global status report on alcohol. Geneva; 2011.
2. Hannuksela ML, Liisanantti MK, Nissinen AE, Savolainen MJ. Biochemical markers of alcoholism. Clin Chem Lab Med. 2007;45: 953-61.
3. Auwarter V, Sporkert F, Hartwig S, Pragst F, Vater H, Diefenbacher A. Fatty acid ethyl esters in hair as markers of alcohol consumption. Segmental hair analysis of alcoholics, social drinkers, and teetotalers. Clin Chem. 2001;47: 2114-23.
4. Lees R, Kingston R, Williams TM, Henderson G, Lingford-Hughes A, Hickman M. Comparison of ethyl glucuronide in hair with self-reported alcohol consumption. Alcohol Alcohol. 2012;47: 267-72.
5. Kintz P. Consensus of the society of hair testing on hair testing for chronic excessive alcohol consumption 2011. Forensic Sci Int. 2012;218: 2.
6. Schubert W, Mattern R. Beurteilungskriterien: Urteilsbildung in der Medizinisch-Psychologischen Fahreignungsdiagnostik. Bonn: Kirschbaumverlag; 2008.
7. World Health Organization. Global status report on alcohol. Geneva; 2004.
8. Pragst F, Rothe M, Moench B, Hastedt M, Herre S, Simmert D. Combined use of fatty acid ethyl esters and ethyl glucuronide in hair for diagnosis of alcohol abuse: interpretation and advantages. Forensic Sci Int. 2010;196: 101-10.
9. Gareri J, Appenzeller B, Walasek P, Koren G. Impact of hair-care products on FAEE hair concentrations in substance abuse monitoring. Anal Bioanal Chem. 2011;400: 183-8.
10. Suesse S, Pragst F, Mieczkowski T, Selavka CM, Elian A, Sachs H, Hastedt M, Rothe M, Campbell J. Practical experiences in application of hair fatty acid ethyl esters and ethyl glucuronide for detection of chronic alcohol abuse in forensic cases. Forensic Sci Int. 2012;218: 82-91.
11. Martins Ferreira L, Binz T, Yegles M. The influence of ethanol containing cosmetics on ethyl glucuronide concentration in hair. Forensic Sci Int. 2012;218: 123-5.
12. Morini L, Zucchella A, Polettini A, Politi L, Groppi A. Effect of bleaching on ethyl glucuronide in hair: an in vitro experiment. Forensic Sci Int. 2010;198: 23-7.
13. Kharbouche H, Faouzi M, Sanchez N, Daeppen JB, Augsburger M, Mangin P, Staub C, Sporkert F. Diagnostic performance of ethyl glucuronide in hair for the investigation of alcohol drinking behavior: a comparison with traditional biomarkers. Int J Legal Med. 2012;126: 243-50.
14. Morini L, Varango C, Filippi C, Rusca C, Danesino P, Cheli F, Fusini M, Iannello G, Groppi A. Chronic excessive alcohol consumption diagnosis: comparison between traditional biomarkers and ethyl glucuronide in hair, a study on a real population. Ther Drug Monit. 2011;33: 654-7.
15. Pirro V, Valente V, Oliveri P, De Bernardis A, Salomone A, Vincenti M. Chemometric evaluation of nine alcohol biomarkers in a large population of clinically-classified subjects: pre-eminence of ethyl glucuronide concentration in hair for confirmatory classification. Anal Bioanal Chem. 2011;401: 2153-64.
16. Wurst FM, Yegles M, Alling C, Aradottir S, Dierkes J, Wiesbeck GA, Halter CC, Pragst F, Auwaerter V. Measurement of direct ethanol metabolites in a case of a former driving under the influence (DUI) of alcohol offender, now claiming abstinence. Int J Legal Med. 2008;122: 235-9.
17. Hastedt M, Herre S, Pragst F, Rothe M, Hartwig S. Workplace alcohol testing program by combined use of ethyl glucuronide and fatty acid ethyl esters in hair. Alcohol Alcohol. 2012;47: 127-32.
18. Hartwig S, Auwarter V, Pragst F. Effect of hair care and hair cosmetics on the concentrations of fatty acid ethyl esters in hair as markers of chronically elevated alcohol consumption. Forensic Sci Int. 2003;131: 90-7.
19. Sporkert F, Kharbouche H, Augsburger MP, Klemm C, Baumgartner MR. Positive EtG findings in hair as a result of a cosmetic treatment. Forensic Sci Int. 2012;218: 97-100.
20. Meregalli M, Giacomini V, Lino S, Marchetti L, DeFeo T, Cappellini MD, Fiorelli G. Carbohydrate-deficient transferrin in alcohol and nonalcohol abusers with liver disease. Alcohol Clin Exp Res. 1995;19: 1525-7.
21. Kharbouche H, Steiner N, Morelato M, Staub C, Boutrel B, Mangin P, Sporkert F, Augsburger M. Influence of ethanol dose and pigmentation on the incorporation of ethyl glucuronide into rat hair. Alcohol. 2010;44: 507-14.
22. Agius R, Kintz P. Guidelines for European workplace drug and alcohol testing in hair. Drug Test Anal. 2010;2: 367-76.