Leflunomide addition in patients with articular manifestations of psoriatic arthritis resistant to methotrexate

Rheumatology International

Volumn 33, Issue 11, 2013, Pages 2917-2920

  Sakellariou, Grigorios T ^a   Sayegh, Fares E ^b   Anastasilakis, Athanasios D ^a   Kapetanos, George A ^b  

^a 424 General Army Hospital   (Greece)

^b PAPAGEORGIOU GENERAL HOSPITAL   (Greece)

Author keywords

Combination; Leflunomide; Methotrexate; Psoriatic arthritis; Therapy

Indexed keywords

C REACTIVE PROTEIN; LEFLUNOMIDE; METHOTREXATE;

ADULT; ARTHROPATHY; ARTICLE; CLINICAL ARTICLE; DAS28; DRUG EFFICACY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; MALE; POLYARTICULAR DISEASE; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; REMISSION;

ADULT; ANTIRHEUMATIC AGENTS; ARTHRITIS, PSORIATIC; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; ISOXAZOLES; MALE; METHOTREXATE; MIDDLE AGED; RETREATMENT; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84886728119     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2534-x     Document Type: Article

References (15)

1. Ritchlin CT, Kavanaugh A, Gladman DD, Mease PJ, Helliwell P, Boehncke WH, For the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), et al. (2009) Treatment recommendations for psoriatic arthritis. Ann Rheum Dis 68:1387-1394
2. Gossec L, Smolen JS, Gaujoux-Viala C, Ash Z, Marzo-Ortega H, van der Heijde D, et al. (2012) European league against rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies. Ann Rheum Dis 71:4-12
3. Fraser AD, van Kuijk AW, Westhovens R, Karim Z, Wakefield R, Gerards AH, et al. (2005) A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus ciclosporin in patients with active psoriatic arthritis. Ann Rheum Dis 64:859-864
4. Knevel R, Schoels M, Huizinga TW, Aletaha D, Burmester GR, Combe B, et al. (2010) Current evidence for a strategic approach to the management of rheumatoid arthritis with disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis 69:987-994
5. Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, et al. (2002) Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 137:726-733
6. Sakellariou GT, Sayegh FE, Kapatenos GA, Berberidis C (2012) Efficacy of leflunomide addition in relation to prognostic factors for patients with active early rheumatoid arthritis failing to methotrexate in daily practice. Clin Rheumatol 31:163-167
7. Kaul A, O'Reilly DT, Slack RK, Collins D, Walmsley J, Duke O, Kiely PD (2008) Tolerability of methotrexate and leflunomide combination therapy for inflammatory arthritis in routine clinical practice: results of a four-centre study. Rheumatology 47:1430-1431
8. Curtis JR, Beukelman T, Onofrei A, Cassell S, Greenberg JD, Kavanaugh A, et al. (2010) Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide. Ann Rheum Dis 69:43-47
9. Bird P, Griffiths H (2010) Multi-centre, cross-sectional, observational study of the safety of methotrexate and leflunomide in combination in the treatment of patients with rheumatoid arthritis. The SMILE study - safety of methotrexate in combination with leflunomide. Arthritis Rheum 62(Suppl 10):319
10. Liang GC, Barr WG (2001) Open trial of leflunomide for refractory psoriasis and psoriatic arthritis. J Clin Rheumatol 7:366-370
11. Zhang GL, Huang F, Zhang JL, Li XF (2009) A clinical study of leflunomide and methotrexate therapy in psoriatic arthritis. Zhonghua Nei Ke Za Zhi 48:570-574
12. Glintborg B, Østergaard M, Dreyer L, Krogh NS, Tarp U, Hansen MS, et al. (2011) Treatment response, drug survival, and predictors thereof in 764 patients with psoriatic arthritis treated with anti-tumor necrosis factor α therapy: results from the nationwide danish DANBIO registry. Arthritis Rheum 63:382-390
13. Saad AA, Ashcroft DM, Watson KD, Symmons DP, Noyce PR, Hyrich KL, On behalf of the BSRBR (2010) Efficacy and safety of anti-TNF therapies in psoriatic arthritis: an observational study from the british society for rheumatology biologics register. Rheumatology 49:697-705
14. Kaltwasser JP, Nash P, Gladman D, Rosen CF, Behrens F, Jones P, For the Treatment of Psoriatic Arthritis Study Group, et al. (2004) Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo-controlled clinical trial. Arthritis Rheum 50:1939-1950
15. Baranauskaite A, Raffayová H, Kungurov NV, Kubanova A, Venalis A, Helmle L, et al. RESPOND investigators (2012) Infliximab plus methotrexate is superior to methotrexate alone in the treatment of psoriatic arthritis in methotrexate-naive patients: the RESPOND study. Ann Rheum Dis 71:541-548