Root causes, clinical effects, and outcomes of unintentional exposures to buprenorphine by young children

Journal of Pediatrics

Volumn 163, Issue 5, 2013, Pages

  Lavonas, Eric J ^a,b   Banner, William ^c,d   Bradt, Pamela ^e   Bucher Bartelson, Becki ^a   Brown, Kimberly R ^a   Rajan, Pradeep ^f   Murrelle, Lenn ^f   Dart, Richard C ^a,b   Green, Jody L ^a  

^a ROCKY MOUNTAIN POISON AND DRUG CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

^d INTEGRIS BAPTIST MEDICAL CENTER   (United States)

^e The Degge Group Ltd   (United States)

^f Venebio Group LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; BUPRENORPHINE PLUS NALOXONE;

ARTICLE; CHILD; DRUG EXPOSURE; DRUG FORMULATION; DRUG STORAGE; DRUG SURVEILLANCE PROGRAM; FEMALE; HUMAN; LETHARGY; MAJOR CLINICAL STUDY; MALE; MIOSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATION DEPRESSION; ROOT CAUSE ANALYSIS; VOMITING;

EID: 84886726146     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2013.06.058     Document Type: Article

References (25)

1. R.L. Franklin, and G.B. Rodgers Unintentional child poisonings treated in United States hospital emergency departments: national estimates of incident cases, population-based poisoning rates, and product involvement Pediatrics 122 2008 1244 1251
2. G.R. Bond, R.W. Woodward, and M. Ho The growing impact of pediatric pharmaceutical poisoning J Pediatr 160 2012 265 270.e1
3. Centers for Disease Control and Prevention NCfHS. Data for year 2009 are compiled from the Multiple Cause of Death File 2009, Series 20 No. 2O, 2012, Data for year 2008 are compiled from the Multiple Cause of Death File 2008, Series 20 No. 2N, 2011, data for year 2007 are compiled from Multiple Cause of Death File 2007, Series 20 No. 2M, 2010, data for years 2005-2006 data are compiled from Multiple Cause of Death File 2005-2006, Series 20, No. 2L, 2009, and data for years 1999-2004 are compiled from the Multiple Cause of Death File 1999-2004, Series 20, No. 2J, 2007. Underlying Cause of Death 1999-2009 on CDC WONDER Online Database, released 20122.
4. S.F. Schillie, N. Shehab, K.E. Thomas, and D.S. Budnitz Medication overdoses leading to emergency department visits among children Am J Prev Med 37 2009 181 187
5. B. Bar-Oz, Z. Levichek, and G. Koren Medications that can be fatal for a toddler with one tablet or teaspoonful: a 2004 update Paediatr Drugs 6 2004 123 126
6. J.E. Bailey, E. Campagna, and R.C. Dart The underrecognized toll of prescription opioid abuse on young children Ann Emerg Med 53 2009 419 424
7. CDC Emergency department visits and hospitalizations for buprenorphine ingestion by children-United States, 2010-2011 MMWR 62 2013 56
8. D.A. Fiellin, M.V. Pantalon, M.C. Chawarski, B.A. Moore, L.E. Sullivan, and P.G. O'Connor Counseling plus buprenorphine-naloxone maintenance therapy for opioid dependence N Engl J Med 355 2006 365 374
9. Reckitt Benckiser Pharmaceuticals, Inc. Richmond, VA; Medication Guide: Suboxone (buprenorphine and naloxone sublingual tablet), Rx Only; 2011. Available at: http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/ 020733s007s008lbl.pdf. Accessed October 26, 2012.
10. B.D. Hayes, W. Klein-Schwartz, and S. Doyon Toxicity of buprenorphine overdoses in children Pediatrics 121 2008 e782 e786
11. S. Okie A flood of opioids, a rising tide of deaths N Engl J Med 363 2010 1981 1985
12. Substance Abuse and Mental Health Services Administration. Rockville, MD; Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings; 2011. Available at: http://www.samhsa.gov/data/NSDUH/ 2k10ResultsRev/NSDUHresultsRev2010.pdf. Accessed August 8, 2012.
13. T.J. Cicero, R.C. Dart, J.A. Inciardi, G.E. Woody, S. Schnoll, and A. Munoz The development of a comprehensive risk-management program for prescription opioid analgesics: researched abuse, diversion and addiction-related surveillance (RADARS) Pain Med 8 2007 157 170
14. E.J. Winter, J. Davis, B. Bucher-Bartleson, R. Westberry, J.L. Green, and E.J. Lavonas Systematic misclassification in product-specific coding of poison center data: the example of buprenorphine in the RADARS(R) system poison center program Clin Toxicol 50 2012 633
15. Reckitt Benckiser Pharmaceuticals, Inc. Subxone, Subutex-Important Safety Information for Prescribers; 2011. Available at: http://www.suboxone.com/hcp/ rems/pdfs/REMS-Physicians-Intro.pdf. Accessed August 8, 2012.
16. AAPCC. National Poison Data System (NPDS) Reference Manual. 2007. Available at: http://www.aapcc.org/data-system. August 8, 2012.
17. CFR - Code of Federal Regulations Title 21; Available at: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=310. 305. Accessed September 17, 2012.
18. National Cancer Institute. Common Terminology Criteria for Adverse Events, v. 4.03; 2010. Available at: http://ctep.cancer.gov/protocolDevelopment/ electronic-applications/ctc.htm#ctc-40. Accessed October 26. 2012.
19. NCI Common Terminology Criteria for Adverse Events (CTCAE) criteria 2010 National Cancer Institutes, National Institutes of Health Bethesda, MD
20. R.C. Dart, I.M. Paul, G.R. Bond, D.C. Winston, A.S. Manoguerra, and R.B. Palmer Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications Ann Emerg Med 53 2009 411 417
21. N. Dasgupta, E.J. Bailey, T. Cicero, J. Inciardi, M. Parrino, and A. Rosenblum Post-marketing surveillance of methadone and buprenorphine in the United States Pain Med 11 2010 1078 1091
22. CDC Buprenorphine prescribing practices and exposures reported to a poison center-Utah, 2002-2011 MMWR 61 2012 997 1001
23. CPSC. Poison Prevention Packaging Act, Codified at 15 U.S.C. §§ 1471-1477. Consumer Product Safety Commission; 2008.
24. FDA. Briefing Documnet from Drug Safety and Risk Management Advisory Committee, January 24-25, 2012. Available at: http://www.fda.gov/downloads/ AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ DrugSafetyandRiskManagementAdvisoryCommittee/UCM334276.pdf.23. Accessed February 26, 2013.
25. P. Michel, J.L. Quenon, A.M. de Sarasqueta, and O. Scemama Comparison of three methods for estimating rates of adverse events and rates of preventable adverse events in acute care hospitals BMJ 328 2004 199