메뉴 건너뛰기




Volumn 10, Issue 11, 2013, Pages 618-619

Dyslipidaemia: PCSK9 antibodies: A dividend of the genomics revolution

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN; EVOLOCUMAB; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MIPOMERSEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PCSK9; PLACEBO; TORCETRAPIB; UNCLASSIFIED DRUG;

EID: 84886722004     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2013.139     Document Type: Short Survey
Times cited : (6)

References (10)
  • 1
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen, J. C., Boerwinkle, E., Mosley, T. H. Jr & Hobbs, H. H. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354, 1264-1272 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3    Hobbs, H.H.4
  • 2
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen, J. et al. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat. Genet. 37, 161-165 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 161-165
    • Cohen, J.1
  • 3
    • 34548175537 scopus 로고    scopus 로고
    • Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis
    • Qian, Y. W. et al. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J. Lipid Res. 48, 1488-1498 (2007).
    • (2007) J. Lipid Res. , vol.48 , pp. 1488-1498
    • Qian, Y.W.1
  • 4
    • 67649834099 scopus 로고    scopus 로고
    • Inhibition of PCSK9: A powerful weapon for achieving ideal LDL cholesterol levels
    • Steinberg, D. & Witztum, J. L. Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proc. Natl Acad. Sci. USA 106, 9546-9547 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9546-9547
    • Steinberg, D.1    Witztum, J.L.2
  • 5
    • 60749122013 scopus 로고    scopus 로고
    • Degradation of LDLR protein mediated by 'gain of function' PCSK9 mutants in normal and ARH cells
    • Fasano, T., Sun, X. M., Patel, D. D. & Soutar, A. K. Degradation of LDLR protein mediated by 'gain of function' PCSK9 mutants in normal and ARH cells. Atherosclerosis 203, 166-171 (2009).
    • (2009) Atherosclerosis , vol.203 , pp. 166-171
    • Fasano, T.1    Sun, X.M.2    Patel, D.D.3    Soutar, A.K.4
  • 7
    • 84870478439 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): A randomised, placebo-controlled, dose-ranging, phase 2 study
    • Giugliano, R. P. et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study. Lancet 380, 2007-2017 (2012).
    • (2012) Lancet , vol.380 , pp. 2007-2017
    • Giugliano, R.P.1
  • 8
    • 84883232230 scopus 로고    scopus 로고
    • AMG 145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: An analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial
    • Desai, N. R. et al. AMG 145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment With Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined With Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial. Circulation 128, 962-969 (2013).
    • (2013) Circulation , vol.128 , pp. 962-969
    • Desai, N.R.1
  • 9
    • 73549108724 scopus 로고    scopus 로고
    • Lp(a)lipoprotein redux-from curious molecule to causal risk factor
    • Kathiresan, S. Lp(a) lipoprotein redux-from curious molecule to causal risk factor. N. Engl. J. Med. 361, 2573-2574 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2573-2574
    • Kathiresan, S.1
  • 10
    • 78649888517 scopus 로고    scopus 로고
    • Lipoprotein(a) as a cardiovascular risk factor: Current status
    • Nordestgaard, B. G. et al. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur. Heart J. 31, 2844-2853 (2010).
    • (2010) Eur. Heart J. , vol.31 , pp. 2844-2853
    • Nordestgaard, B.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.