Update on Preventive Therapy (Prophylaxis) for Hereditary Angioedema

Immunology and Allergy Clinics of North America

Volumn 33, Issue 4, 2013, Pages 495-503

  Frank, Michael M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Androgens; Antifibrinolytics; C1 inhibitor; Hereditary angioedema; Prophylaxis

Indexed keywords

AMINOCAPROIC ACID; ANDROGEN; BRADYKININ; COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT COMPONENT C4; DANAZOL; FRESH FROZEN PLASMA; HISTAMINE; KININOGEN; PLACEBO; PREKALLIKREIN; PROGESTERONE; STANOZOLOL; TRANEXAMIC ACID;

ACUTE DISEASE; ANDROGEN THERAPY; ANGIONEUROTIC EDEMA; ANXIETY; ARTERIAL WALL THICKNESS; CHOLESTEROL BLOOD LEVEL; COMPLEMENT ACTIVATION; DEPRESSION; DRUG EFFICACY; DRUG MEGADOSE; DRUG WITHDRAWAL; FATIGUE; FIBRINOLYTIC THERAPY; HAIR LOSS; HEADACHE; HEMATURIA; HETEROZYGOTE; HUMAN; HYPERTENSION; LIBIDO DISORDER; LIVER CELL CARCINOMA; LIVER CYST; LIVER DISEASE; MENSTRUAL IRREGULARITY; MUSCLE WEAKNESS; MYALGIA; MYOPATHY; NANOFILTRATION; PRIORITY JOURNAL; REVIEW; SHORT COURSE THERAPY; SIDE EFFECT; THROMBOSIS; UNSPECIFIED SIDE EFFECT; VIRILIZATION; WEIGHT GAIN;

ANDROGENS; ANTIFIBRINOLYTICS; C1 INHIBITOR; HEREDITARY ANGIOEDEMA; PROPHYLAXIS;

AMINOCAPROIC ACID; ANGIOEDEMAS, HEREDITARY; CLINICAL TRIALS AS TOPIC; COMPLEMENT C1 INACTIVATOR PROTEINS; HUMANS; PREMEDICATION;

EID: 84886718406     PISSN: 08898561     EISSN: 15578607     Source Type: Journal    
DOI: 10.1016/j.iac.2013.07.005     Document Type: Review

References (29)

1. Wilson D.A., Bork K., Shea E.P., et al. Economic costs associated with acute attacks and long-term management of hereditary angioedema. Ann Allergy Asthma Immunol 2010, 104(4):314-320.
2. Nilsson I.M., Andersson L., Bjorkman S.E. Epsilon-aminocaproic acid (E-ACA) as a therapeutic agent based on 5 year's clinical experience. Acta Med Scand Suppl 1966, 448:1-46.
3. Lundh B., Laurell A.B., Wetterqvist H., et al. Acase of hereditary angioneurotic oedema, successfully treated with epsilon-aminocaproic acid. Studies on C'1 esterase inhibitor, C'1 activation, plasminogen level and histamine metabolism. Clin Exp Immunol 1968, 3(7):733-745.
4. Champion R.H., Lachmann P.J. Hereditary angio-oedema treated with E-aminocaproic acid. Br J Dermatol 1969, 81(10):763-765.
5. Frank M.M., Sergent J.S., Kane M.A., et al. Epsilon aminocaproic acid therapy of hereditary angioneurotic edema. A double-blind study. NEngl J Med 1972, 286(15):808-812.
6. Blohme G. Treatment of hereditary angioneurotic oedema with tranexamic acid. A random double-blind cross-over study. Acta Med Scand 1972, 192(4):293-298.
7. Frank M.M., Gelfand J.A., Atkinson J.P. Hereditary angioedema: the clinical syndrome and its management. Ann Intern Med 1976, 84(5):580-593.
8. Chinniah N., Katelaris C.H. Hereditary angioedema and pregnancy. Aust N Z J Obstet Gynaecol 2009, 49(1):2-5.
9. Bouillet L., Longhurst H., Boccon-Gibod I., et al. Disease expression in women with hereditary angioedema. Am J Obstet Gynecol 2008, 199(5):484.e1-484.e4.
10. Gadek J.E., Hosea S.W., Gelfand J.A., et al. Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor. NEngl J Med 1980, 302(10):542-546.
11. Sheffer A.L., Fearon D.T., Austen K.F. Clinical and biochemical effects of stanozolol therapy for hereditary angioedema. JAllergy Clin Immunol 1981, 68(3):181-187.
12. Drouet C., Desormeaux A., Robillard J., et al. Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P. JAllergy Clin Immunol 2008, 121(2):429-433.
13. Bork K., Barnstedt S.E. Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema. JAm Dent Assoc 2003, 134(8):1088-1094.
14. Farkas H., Czaller I., Csuka D., et al. Long-term efficacy of danazol treatment in hereditary angioedema. Eur J Clin Invest 2010, 41(3):256-262.
15. Zurlo J.J., Frank M.M. The long-term safety of danazol in women with hereditary angioedema. Fertil Steril 1990, 54(1):64-72.
16. Cicardi M., Bergamaschini L., Cugno M., et al. Long-term treatment of hereditary angioedema with attenuated androgens: a survey of a 13-year experience. JAllergy Clin Immunol 1991, 87(4):768-773.
17. Szeplaki G., Varga L., Valentin S., et al. Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema. JAllergy Clin Immunol 2005, 115(4):864-869.
18. Birjmohun R.S., Kees Hovingh G., Stroes E.S., et al. Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema. Clin Ther 2008, 30(12):2314-2323.
19. Bork K., Bygum A., Hardt J. Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. Ann Allergy Asthma Immunol 2008, 100(2):153-161.
20. Church J.A. Oxandrolone treatment of childhood hereditary angioedema. Ann Allergy Asthma Immunol 2004, 92(3):377-378.
21. Farkas H., Harmat G., Fust G., et al. Clinical management of hereditary angio-oedema in children. Pediatr Allergy Immunol 2002, 13(3):153-161.
22. Agostoni A., Bergamaschini L., Martignoni G., et al. Treatment of acute attacks of hereditary angioedema with C1-inhibitor concentrate. Ann Allergy 1980, 44(5):299-301.
23. Bork K., Witzke G. Hereditares angioneurotisches Odem. Klinik sowie erweiterte diagnostische und therapeutische Moglichkeiten. Dtsch Med Wochenschr 1979, 104(11):405-409. [in German].
24. Waytes A.T., Rosen F.S., Frank M.M. Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate. NEngl J Med 1996, 334:1630-1634.
25. Zuraw B.L., Busse P.J., White M., et al. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. NEngl J Med 2010, 363(6):513-522.
26. Pickering R.J., Good R.A., Kelly J.R., et al. Replacement therapy in hereditary angioedema. Successful treatment of two patients with fresh frozen plasma. Lancet 1969, 1(7590):326-330.
27. Wall R.T., Frank M., Hahn M. Areview of 25 patients with hereditary angioedema requiring surgery. Anesthesiology 1989, 71(2):309-311.
28. Jaffe C.J., Atkinson J.P., Gelfand J.A., et al. Hereditary angioedema: the use of fresh frozen plasma for prophylaxis in patients undergoing oral surgery. JAllergy Clin Immunol 1975, 55(6):386-393.
29. Bowen T., Hebert J., Ritchie B., et al. Canadian 2003 International Consensus Algorithm for the diagnosis, therapy, and management of hereditary angioedema. JAllergy Clin Immunol 2004, 114(3):629-637.